Remicade Pretreatment with oral prednisone

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andrealeigh71
Regular Member


Date Joined Sep 2009
Total Posts : 96
   Posted 7/5/2010 9:12 AM (GMT -7)   
I am wondering if anyone has taken oral prednisone the day before and day of their Remicade infusion.  My husband may have had a delayed reaction of joint pain from his last infusion and the Dr. wants to try the prednisone before the infusion this time.  We are also waiting to hear back about antibodies to Remicade as well.  Any input would greatly help us!!!!

cupcakespinkgal
Veteran Member


Date Joined Jun 2010
Total Posts : 1270
   Posted 7/5/2010 10:13 AM (GMT -7)   
I have. I also had an infusion where days after I had terrible joint pain, I couldn't even wash my hair or put on my bra it hurt so bad. After that the Dr had me take a high dose of prednisone the day before and day of. I never had the joint pain again. Not too soon after that I moved and had to find a new Dr, he said I should only be taking IV Bendadryl before that the prednisone didn't do anything.

Not sure which Dr was right, but never had the joint pain again and had a few more infusions taking Prednisone and oral Benadryl before and then several with IV Benadryl before.
Diagnosed with Crohn's in 1998, father has UC we were diagnosed at the same age.

Currently on 10 mg Prednisone, 4g Sulfasalzine, VSL#3, Vitamin C, Calcium, Magnesium, D3, Chlorophyll, and LDN. Previously on Remicade, just stopped Humira after 9 months, wasn't working.

No surgeries so far.


andrealeigh71
Regular Member


Date Joined Sep 2009
Total Posts : 96
   Posted 7/5/2010 1:09 PM (GMT -7)   
Thank you so much cupcakespinkgal.  I also requested that he get IV steroids right before the infusion as well as Benadryl.  Did they try to decrease your Remicade dose at all after that joint pain incident or just added the prednisone/benadryl???

cupcakespinkgal
Veteran Member


Date Joined Jun 2010
Total Posts : 1270
   Posted 7/5/2010 3:00 PM (GMT -7)   
They did not reduce my Remicade dose, just kept pre-medicating me with the Prednisone and Benadryl. It is interesting because I had 2 bad infusions in a row, one before the joint one with an allergic reaction and couldn't breath, then the next one with the joint pain after. But once they started pre-medicating me I did fine on all my infusions after that and I did them for about 5 more years.

I hope it works out for him, I was pretty nervous for the next few infusions after all that, but Remicade helped so much it was worth trying. I had about 5 -6 years with no sympoms and eating pretty normal.
Diagnosed with Crohn's in 1998, father has UC we were diagnosed at the same age.

Currently on 10 mg Prednisone, 4g Sulfasalzine, VSL#3, Vitamin C, Calcium, Magnesium, D3, Chlorophyll, and LDN. Previously on Remicade, just stopped Humira after 9 months, wasn't working.

No surgeries so far.


andrealeigh71
Regular Member


Date Joined Sep 2009
Total Posts : 96
   Posted 7/5/2010 4:38 PM (GMT -7)   
Yeah that's the thing---the Remicade has changed his (and my) life and we don't want to have to stop the infusions.... He's due on Wednesday so hopefully it's great.  What did you end up doing after 5 years of Remicade?

cupcakespinkgal
Veteran Member


Date Joined Jun 2010
Total Posts : 1270
   Posted 7/5/2010 6:28 PM (GMT -7)   
Well after the 5 years my colon was doing pretty good so I was able to maintain remission for 2 years after that with just Sulfasalazine and probiotics. Then had a more severe flare and tried Humira last fall. I was hopeful because the Remicade worked so well but I did not do well with the Humira at all. I was on steroids almost the whole time because my doctor wanted to keep giving it more time to kick in and every time I dropped the steroids while on the Humira I flared.

Actually I think I am doing better now with the Humira out of my system. I am doing just Sulfasalazine, prednisone and vitamins and stronger probiotics. I finally got my prednisone down to 10 mg so I am starting Low dose Naltrexone as an alternative therapy.

I hope all goes well on Wednesday! All in all, the Remicade gave me the best quality of life for around 7 - 8 years and really even with these last flares I have never been as sick as I was the years before Remicade (knock on wood!)
Diagnosed with Crohn's in 1998, father has UC we were diagnosed at the same age.

Currently on 10 mg Prednisone, 4g Sulfasalzine, VSL#3, Vitamin C, Calcium, Magnesium, D3, Chlorophyll, and LDN. Previously on Remicade, just stopped Humira after 9 months, wasn't working.

No surgeries so far.


Grandpato2
Veteran Member


Date Joined Dec 2009
Total Posts : 681
   Posted 7/6/2010 12:05 AM (GMT -7)   
Benadryl is the first level of treatment for allergic reaction. Steroids (prednisone) are the second. Adrenalyn is the third.
Male, 55 years old with Crohn's since 15 years old, diagnosed at age 46. Terminal ileum resected 2002. 5 months of remission. Crohn's has now been active since May, 2003. Had a gall bladder removed Nov. of 2009. Currently on Remicade every 8 weeks, Nexium, Iron, B-12 injection every 4 weeks, Morphine Sulfate as needed for pain. Cymbalta for long term pain control. In the past, 5-asa Salofalk, Asacol, Entocort,  Imuran and Prednisone.


swon888
Regular Member


Date Joined Jun 2010
Total Posts : 91
   Posted 7/31/2010 1:21 PM (GMT -7)   
I had been on Remicade for years and it's been working very well. but I had been off Remicade for 4 month, than go back to it. the Remicade did not seem to have the effect it use to. this is my 3rd infusion and it only lasted for 2 weeks. than the next 4 weeks, I am under extreme pain. I had to get some Tylenol just to get me going. I mention it to my doctor. He also gave me some Prednisone. 10mg per day. this is the 3rd day I'm on it. it didn't seem to help at all. I still have to take some Tylenol just to come my pain down. I will be give my doctor a call next week and see if I can increase the prednisone or not. not sure what else to go by with so much pain.

1asalsa
Regular Member


Date Joined Feb 2010
Total Posts : 40
   Posted 8/1/2010 9:54 AM (GMT -7)   
I got hives 10 days after the 3rd infusion; after the GI doctor consulted w/ the drug company, they had me go see a dermatologist, then once diagnosis was confirmed, they had me take 40 mg of pred 2 days before and 2 days after each infusion.. Also get the Solumedrol and Benadryl with infusion. Since then I have gradually decreased the pred before and after infusion, but I do still take it each time, and have not had any problems since.

PV
Veteran Member


Date Joined May 2006
Total Posts : 1177
   Posted 8/1/2010 10:36 AM (GMT -7)   
My husband also suffers from flu like symptoms including severe joint and muscle pain after a remicade infusion. This usually lasts around 2 days after infusion, and then he's back to normal. So, the doc put him on IV benedryl and 40 mgs of solumedrol, and now after the infusion, he runs a fever which is controlled with tylenol and his joint and muscle pain is mild and manageable.

PV
Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Crohn's in Remission since June 2008
C-diff recurrence Sep 2009
Reactive Arthritis Nov 2009
Currently c-diff free
Osteopenia of spine (Mar 2010)
Canasa (1gm), Lialda (4.8 gms), Remicade (8 weeks)
Currently In Remission

tsitodawg
Veteran Member


Date Joined Sep 2006
Total Posts : 845
   Posted 8/1/2010 11:52 PM (GMT -7)   
Each month when I have my remicade I am always premedicated with both benedryl and cortisteroids through my I.V. This has help tremendously with the whole process.

Ohkeedokee
New Member


Date Joined Aug 2010
Total Posts : 4
   Posted 8/2/2010 1:18 PM (GMT -7)   
When I get my infusion I also have 40mg of prednisone added to the IV Bag as well as Benedryl (due to reaction, burning, numbness) and that has worked for me.
Hope that helps somewhat.
:-)  
Multiple Auto-immune Diseases: Crohns, Type II Diabetes, Lupus, Rheumatoid Arthritis, Fibromyalgia
Colon Resection w/Colostomy & reversal 3mos later 2005
Remicade monthly IV infustion (upped to 9 vials 7/10), currently on 3 month course of entorcort
Think Positive and hopefully the body will follow!

dragonfly137927
Veteran Member


Date Joined Sep 2006
Total Posts : 2527
   Posted 8/2/2010 10:31 PM (GMT -7)   
After getting remicade for a few years I began having adverse reactions. They began treating me not only withthe benadryl and tylenol but also iv pred then eventually pretreat with oral pred. The pred and remicade caused me to have joint issues. I eventually had too many adverse reaction to the remicade and then my ilium perforated therefore I stopped remicade had 4 surgeries and now am on Humira which I have had much more success with i do however have to take 1 dose a week instead of every other
Dx with Crohn's 1987, symptoms as early as 1984.
Temp iliostomy February 2007, reversed June 2007, Ovarian cysts, migraines, allergies (incl food allergies) , oral allergy syndrome (diff than true food allergies), Asthma, Gall Bladder removed 1999, Inguenal hernia 1987
 
 
 

Djin
Regular Member


Date Joined Jan 2010
Total Posts : 265
   Posted 8/3/2010 12:57 PM (GMT -7)   
200 ml of hidrocorticoids (IV) + antihistamin (oral) and no problems at all.

75 mg of imuran helps in the effect and in delaying tha antibody production.

Hope it lasts.
Male, 35 (lovely family of wife and two daughters)
Diagnosed in nov/94 - Started with Prednisone, followed by Pentasa, entocort, flagyl, Imuran, Cipro, etc.
Blockage (popcorn!!) - First Surgery 2001 (no ressection)
Severe bleedind - 2003 - Stopped by 60mg of Prednisone
Stricture leading to a ressection in Dec/2008 - Second Surgery
Now on Remicade + 100 75mg Imuran + Iron (doc said i'm in remission, but I'm not sure at all)
 
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