I'm about to switch to 40mg/week instead of every other week. I've been on Humira for 2 years (after 6 on remicade) and it's just not holding me very well. I've learned that with the biologics you have to find the right dose that will maintain you and then ride it out for as long as you can. I hope I don't sound too jaded, but the biologics don't last forever. So, you take what you can get, make it work, and keep your fingers crossed that with all of the new meds they're working on, you'll buy yourself some time with the Humira until it stops working and then take something new. What concerns you the most about the higher dose?