Muscular Atrophy- weird

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Regular Member

Date Joined Dec 2004
Total Posts : 162
   Posted 8/12/2010 2:34 PM (GMT -6)   
about 3 years ago I had to give myslef methotrexate injections in my leg, I favored my right leg and experienced atrophy at the site.  It went away when I stopped about 3 years ago.  And now, all of a sudden it is back?  Can anyone explain why that could happen?  So strange. 

Veteran Member

Date Joined Sep 2006
Total Posts : 845
   Posted 8/13/2010 12:23 AM (GMT -6)   
My legs have never been the same since I started giving myself methotrexate and cimzia in my thigh. I noticed that my quads are a lot leaner than they used to be and my calf muscles seemed to have gotten bigger with less strength in them. When I was on methotrexate I noticed that sometimes I would hardly be able to walk with one leg and would literally have to lift it with my arms to step into a car or anything over a few inches high. Given the fact that I was only 27 at the time, I found it scary. When I started on cimzia I began to have leg spasms and the weakness again which my doctor attributed to lupus like syndrome. Funny thing is that once I returned to using Remicade again (I had previously used it for 5 years monthly) I have not had lupus like syndrome despite it also being a TNF inhibitor.
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