My legs have never been the same since I started giving myself methotrexate and cimzia in my thigh. I noticed that my quads are a lot leaner than they used to be and my calf muscles seemed to have gotten bigger with less strength in them. When I was on methotrexate I noticed that sometimes I would hardly be able to walk with one leg and would literally have to lift it with my arms to step into a car or anything over a few inches high. Given the fact that I was only 27 at the time, I found it scary. When I started on cimzia I began to have leg spasms and the weakness again which my doctor attributed to lupus like syndrome. Funny thing is that once I returned to using Remicade again (I had previously used it for 5 years monthly) I have not had lupus like syndrome despite it also being a TNF inhibitor.