Thoughts please

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   Posted 8/19/2010 12:10 PM (GMT -6)   
Son's consultant has said again that he can come off of the Pentasa if he wishes(on Azathioprine too) Last time we tried it his inflammatory markers started rising so he started taking Pentasa again and to be fair he had only been on the azathioprine for a couple of months. Now he is 6 months into it and barring the odd rumble is doing ok. I know people say to continue taking maintenance meds does this apply when taking Azathioprine too? Consultant appears to think that the Pentasa isn't really doing anything and it will be less tablets for son to take(he isn't too worried either way)
I would hate for him to pump his body full of meds that he doesn't need  but equally would hate to stop them and him have further problems.

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   Posted 8/19/2010 12:16 PM (GMT -6)   
I don't know what azathioprine does, but Pentasa is pretty safe. Aside from the cost, and restrictions against using aspirin or NSAIDs while taking 5-ASA meds, I don't see the down side.

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Date Joined Mar 2007
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   Posted 8/19/2010 12:24 PM (GMT -6)   
You'll get lots of different opinions on this.

Here's mine: I'd stop the Pentasa. It's not worth the cost or the hassle of taking so many pills. It's of questionable benefit in the first place. It could have been purely coincidental before when his inflammatory markers increased after stopping it the first time. And once somebody is stable on azathioprine (imuran), I think there's even less reason to stay on Pentasa.

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Date Joined Apr 2005
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   Posted 8/19/2010 1:17 PM (GMT -6)   
If you would like you can try stopping the Pentasa, but if symptoms start to return put him back on it. The Imuran is a good med. But you can do a trial without the Pentasa and see what happens. Good luck!
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Crohn's Disease for over 34 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, Calcium, Vit D, and Xanax prn. Resections in 2002 & 2005. Also diagnosed w/ Fibromyalgia, Osteoarthritis, & Anxiety. Currently my Crohns is in remission, but my joints are going crazy!
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Date Joined Dec 2005
Total Posts : 1768
   Posted 8/19/2010 6:07 PM (GMT -6)   
I second what Nanners says. That would be what I would do.

32 yr old female-dx with Crohn's in '97 after emergency resection and appendectomy, 2nd resection '05, Bilateral pulmonary emboli 10/09
Currently on Humira, Omeprazole, Effexor, Seroquel, Calcium, Vit D
Coumadin stopped 3/15/10!!!!

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Date Joined Jan 2010
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   Posted 8/20/2010 2:11 AM (GMT -6)   
Thanks l for the input.

I guess it is worth another go.

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Date Joined Feb 2004
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   Posted 8/20/2010 8:00 AM (GMT -6)   
I stayed on Imuran for years and they only took me off of it when I had lots of kidney stones. The imuran did not cause this but I could not take it and the med for stones together so I was put on Methotrexate.
If we would read the secret history of our enemies,we would find in each mans life sorrow and suffering enough to disarm all hostility.

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Date Joined Apr 2005
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   Posted 8/20/2010 8:24 AM (GMT -6)   
I was on Pentasa and 6MP (imuran cousin) for years. When I stopped taking the Pentasa, my D decreased, so my 2 cents is to give it a shot and see what happens.

CD 20 years officially, 30 unofficially. 3 resections '93, '95 '97
Managing with strict low residue diet, keeping symptoms to a minimum. All test show small amount of ulceration, still have occasional blockages. But still have a great time with my 2 daughters and husband!

Prednisone, 6MP,Prevacid, B12 shots, Bentyl, Xifaxan.....

Veteran Member

Date Joined Mar 2007
Total Posts : 1576
   Posted 8/20/2010 12:30 PM (GMT -6)   
I just went throught the exact same thing with our GI. She said, that she feels the Pentasa isn't an effective drug, and to continue with Imuran only. My personal contention was why mess with this combination if it's apparently working. I guess it's a matter of opinion. She did relent abit, and suggested we cut the Pentasa in half for a few months before eliminating it. 
Also, Imuan does take quite some time to reach it's full effectiveness. Up to 6 months. 
My daughter was diagnosed Feb. 19/07, (13 yrs. old at time of diagnosis), with Crohn's of the Terminal Illium. Has used Prednisone and Pentasa. Started Imuran (02/09), had an abdominal abscess (12/08). 2cm of Stricture.

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Date Joined Jan 2010
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   Posted 8/21/2010 9:23 AM (GMT -6)   
decisions, decisions.
Son doesn't have any issues with D, if anything constipation becomes the issue so then thought he may be better on it rather than off.

73monte I agree that if something is working then why mess with the combination.
It is hard when consultant has bascially said do what you want!!

Son says that he would like to try stopping it whilst we still have some in reserve at home and if need be can start them up again immediately should the need arise so I guess that is what he will do.
The upside of this is that he has expresed an opinion on what to do which is great because it means that he is begining to make decisions for himself (small steps :D)
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