I was on remicade for 6 & 1/2 years - the last 9 months of which remi had lost it's effectiveness, but I was too dumb to figure it out. I switched to Humira 2 years ago and I can honestly say that it hasn't done very much to help me. Sorry to be the bearer of bad news, but I think Humira sucks. It barely holds me and I just recently switched to taking it weekly instead of bi-weekly. I think I probably should have been taking it weekly all along. If you are also taking methotrexate then you might have better results. I hope someone else comes along with better news than mine, but so far... I haven't seen much help. It's better for me to take it than not take it, but it doesn't do what I had hoped it would do.