When will Humira start working?

How long did it take to see improvements on Humira?
<1 week - 20.0%
1-2 weeks - 0.0%
3-4 weeks - 0.0%
4-6 weeks - 20.0%
>6 weeks - 40.0%
No improvement on Humira - 20.0%

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Regular Member

Date Joined Aug 2010
Total Posts : 129
   Posted 9/3/2010 5:21 AM (GMT -6)   
I just started Humira on Wednesday after going through a severe flare that hasn't been responding to steroids. My doctor said that there is a chance the medication was started too late or just won't be effective enough to get me out of this flare without surgery. Typically, how soon have people seen improvements on Humira?
26 years old. Diagnosed with Crohn's disease March 2008. Battled a C. diff infection from Summer 2009-Spring 2010. Have been dealing with a severe flare for the past several weeks.

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 9/3/2010 5:25 AM (GMT -6)   
Goodness! It's only been a day or two. Give it some time, mlatida.

I think your best bet would be to not watch and wait, but just to observe changes as they come.

From memory, I noticed rheumie changes first, and within the first few hours / days / weeks. Gut improvements took longer.
Co-Moderator Crohn's Forum.

Medications for Crohn's ~~ Diet and Nutritional Therapy for Crohn's ~~ Dealing with Abscesses and Fistulae ~~

Veteran Member

Date Joined Aug 2007
Total Posts : 884
   Posted 9/3/2010 11:12 AM (GMT -6)   
Seems like it took about a month the first time I was on it.  Just said something to my rheumy last month because it doesn't seem to be working as well this time around.  She said most people get better up until week 12 and then it levels off.  I would give it at least a month.

Regular Member

Date Joined Jul 2008
Total Posts : 383
   Posted 9/3/2010 11:17 AM (GMT -6)   
I noticed GI improvements within a week or two. It seemed to be better the first week after I took the shot and then get worse the second week leading up to the next one.
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