The BIG Question.........

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Regular Member

Date Joined Aug 2010
Total Posts : 28
   Posted 9/4/2010 10:09 AM (GMT -6)   
so i met with my dr this past weds, and he says i should start one of the biologics, due to the severity of inflammation i have.  he has recommended remicade or humira.  he says it my choice, and they both do the same thing, they are just administered differently.  if i understand him right, he says the remicade is done by an iv transfusion every 8 weeks and it takes about 2 hours to do.  the humira is done by a shot weekly that i give myself.  both will leave my feeling somewhat sick for the rest of that day, or the following. 
now i figure, well shouldn't i only feel sick once every 8 weeks, instead of weekly? plus, ive never given myself a shot of anything, but from what ive read on here, it doesn't seem to be as bad as it sounds.
i want to hear from the people that are on either meds, and discuss how they came to make the choice they did, the luck they are having on it, and any complications or side effects they have experienced.  thanks wink

Veteran Member

Date Joined Dec 2005
Total Posts : 1768
   Posted 9/4/2010 11:41 AM (GMT -6)   
When I was on Remicade, I actually felt bad the day of and the day after the infusion. I had a low grade fever and was worn out. I don't have any side effects like that on Humira. I switched from Remicade to Humira because of convenience. Between driving to and from the dr and the infusion, it took about 5 hours for me (lots of traffic here and my doctor isn't close) and I was willing to do injections on myself. Most people only give themselves Humira injections every 2 weeks to begin with. If that doesn't work after some time, your doctor can switch you to every week, but they shouldn't do that to begin with.

Humira has worked better on me than Remicade did. Not to say Remicade didn't work at all, but I still was having partial obstructions because of inflammation and scar tissue at least twice a year. Now my crohn's isn't active (I just have obstructions due to scar tissue now, and they have been farther apart time wise).

32 yr old female-dx with Crohn's in '97 after emergency resection and appendectomy, 2nd resection '05, Bilateral pulmonary emboli 10/09
Currently on Humira, Omeprazole, Effexor, Seroquel, Calcium, Vit D
Coumadin stopped 3/15/10!!!!

Veteran Member

Date Joined Jan 2009
Total Posts : 829
   Posted 9/4/2010 2:07 PM (GMT -6)   
I have tried both Remicade and Humira.

I like Remicade more, first of all I get sick after most of the injections and since you only get Remicade every 8 weeks that means you only get sick every 8 weeks instead of every 2 weeks.
I like going to the doctors for two hours meeting my nurses and reading a good book or chatting to other IBD patients.

Humira is easy but the pain from the injections :S I hate it. It was very good at first but then it got worse and worse.
Now its so bad that I have a big red lump on the injection site, that BURNS for 48 hours after the injection.
I would not say that Humira is all bad, it works better than Remicade for me. My symptoms are very good at the moment.

I would say that you can almost flip a coin to choose :D
But you know if one of them does not work out you can always try the next.

Veteran Member

Date Joined Sep 2006
Total Posts : 2527
   Posted 9/4/2010 2:18 PM (GMT -6)   
I used Remicade from 2001 til 2007 I did develop reactions to it etc. It ended up no longer working for me and ended up with a perforation. I have been on HUmira since 3007 and use it weekly and it has worked better all around (including joints)
Dx with Crohn's 1987, symptoms as early as 1984.
Temp iliostomy February 2007, reversed June 2007, Ovarian cysts, migraines, allergies (incl food allergies) , oral allergy syndrome (diff than true food allergies), Asthma, Gall Bladder removed 1999, Inguenal hernia 1987

Regular Member

Date Joined Sep 2009
Total Posts : 63
   Posted 9/4/2010 6:46 PM (GMT -6)   
I never did try Remicade, but went right to Humira.  I have had no side effects and I give myself shots every other week using the epipen.  It has not made me sick at all.  I have seen improvement, not 100%, but going in the right direction.  I hope whatever you choose will be effective.

Lady G
Regular Member

Date Joined Sep 2006
Total Posts : 321
   Posted 9/4/2010 10:46 PM (GMT -6)   
I just started Remicade, done my first 3 infusions and I've never once felt sick the day of or after it, in fact I usually feel instantly better, relieved and happy/energetic again after my everyone is different of course.   I like that it's just letting others do the work of course, go in, get set up and sit for 3 hours--it's good reading time for me.  Plus with Remicade too, if 8 weeks is too long it can be changed to move to a week that won't hurt you so much if you start reacting or getting sick early...some people get it every 4 weeks if that's all thier body handles--they keep track really good how you're reacting,  how long it's lasting and if changes are needed and all.  But I quite enjoy it so far.
I've never tried Humira though to tell of that one.

Regular Member

Date Joined Apr 2009
Total Posts : 382
   Posted 9/4/2010 11:56 PM (GMT -6)   
I used to be on remicade -- didn't feel sick at all during or after. And my infusions used to take 3-4 hours. I'd pick humira since you have more control over it.
Crohn's diagnosed 6/08
Organic SCD since 4/09
Remicade from 6/09 to 4/10
Low-dose naltrexone since 7/5/10
Boswellia + Natren's Healthy Trinity probiotic + Cinnamon + Wild Oregano Oil + vitamin D

Veteran Member

Date Joined Dec 2009
Total Posts : 681
   Posted 9/5/2010 1:11 AM (GMT -6)   
I've been on remicade 3 years, every 8 weeks, never had any side effects. It's just like saline going in. It helps especially with joint pain from crohn's arthritus. Unfortunately it's effectiveness has slowly decreased by time duration. Eg. now only works for 4 week of the 8 and my govt. will not allow 6 or 4 week infusions for crohns.
Male, 55 years old with Crohn's since 15 years old, diagnosed at age 46. Terminal ileum resected 2002. 5 months of remission. Crohn's has now been active since May, 2003. Had a gall bladder removed Nov. of 2009. Currently on Remicade every 8 weeks, Nexium, Iron, B-12 injection every 4 weeks, Morphine Sulfate as needed for pain. Cymbalta for long term pain control. In the past, 5-asa Salofalk, Asacol, Entocort,  Imuran and Prednisone.

Regular Member

Date Joined Aug 2010
Total Posts : 28
   Posted 9/5/2010 11:08 AM (GMT -6)   
excellent. i appreciate all the helpful insight from everyone. im thinking im gonna start with the remicade, just because of the frequency that it needs to be done, and see where it takes me from there

Regular Member

Date Joined Feb 2006
Total Posts : 211
   Posted 9/5/2010 12:04 PM (GMT -6)   
I was on Remicade short term years ago (thinking bout going back) and I don't remember having any trouble with it. Maybe I was a little tired after the infusion? But nothing major.

I'm on Humira right now (which unforuntately isnt working for me.) and remember thinking it would be so much easier than going to a place, sitting through a 3 hour infusion, etc. (I don't know if this is still the case, but I remember when I was on it years ago, you had to have someone else drive you so I had to make sure my mom was around to drive me to and from the infusion place.) Humira seemed so easy, just suck it up and give yourself a shot, its on your own time, your own house, etc. For some reason I wuss up now; I did the first few injections and was fine and then I misfired a pen and the last 2 times I had to have my stepdad gve it to me because Ive been so anxious about it. It does hurt like crazy, but I find as soon as your done with the shot (around 10 seconds or so) the pain stops. I havent had any problems with the injection site, it just is a little black and blue.

Like someone said, its basically like tossing a coin, because you don't know how your body will react. I thought Humira was going to be my magical answer and for some reason my body isn't responding to it yet at all. But for others, it's a miracle and has really changed their lives.

Good luck with the Remicade, I hope it works for you! :)
25 year old female, diagnosed in Aug '02 after being misdiagnosed with Lyme Disease for a year.

Have been on Prednisone, Asacol, Entocort, Remicade, antibiotics (cipro, flagyl, avalox, etc), and Mercaptopurine (even the lowest dosage was messing up my liver, argh) in the past.

Currently on Humira but isn't working, trying to figure out what to do next.

dixie jo
Regular Member

Date Joined Aug 2010
Total Posts : 30
   Posted 9/6/2010 9:59 PM (GMT -6)   
I,m on remicade now , after the treatment I just go home and sleep it just makes me tired for about a day, I hope that you choose the treatment that is right for you.
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