MESALAMINE (in Asacol) may interact with WARFARIN SODIUM (in Coumadin Tablets) Although the cause of this potential interaction is not known, mesalamine may decrease the anticoagulant effect of warfarin. Warfarin is generally used to prevent your blood from "coagulating" or forming blood clots. When mesalamine and warfarin are used at the same time, your blood may be more likely to clot. Your doctor may want to monitor you closely when therapy with mesalamine is either started or stopped. Blood tests can be used to make sure that you are getting the right amount of warfarin. If you are experiencing problems, it may be necessary to adjust the dose of warfarin.Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is poorly documented and is considered moderate in severity.