And another bit of reading-LDN Crohns Study summary

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vixen
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Date Joined Jan 2010
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   Posted 9/11/2010 9:27 AM (GMT -7)   

NiceCupOfTea
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Date Joined Jan 2010
Total Posts : 8586
   Posted 9/11/2010 3:52 PM (GMT -7)   
Cheers :p

That's the same study which is always cited for LDN and Crohn's. I don't think there are any others. LDN can't be patented, so the drug companies don't research it. Personally, I find it intriguing that LDN works on a diametrically opposite principle to the usual Crohn's drugs: it boosts the immune system rather than suppresses it.

I'd try LDN. In fact, for me my options are a toss up between that and enteral nutrition. The only drawback to LDN is that you do have to be off all steroids, opiate-based painkillers and immunesuppressants first. But presumably you wouldn't be considering it if those traditional meds were working.

vixen
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Date Joined Jan 2010
Total Posts : 794
   Posted 9/12/2010 1:20 AM (GMT -7)   
Oh I don't know, it is still one that I think would be worth trying especially as it has lower side affects. I did ask the IBD nurse whether any of the gasterenterologists were prescribing it at the hospital(he hadn't heard of it) and he said that they had only just started prescribing infliximab there!!

NiceCupOfTea
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Date Joined Jan 2010
Total Posts : 8586
   Posted 9/12/2010 5:18 AM (GMT -7)   
Yeah. It's not exactly a standard treatment yet, to put it mildly. It's hard enough finding a GI who will prescribe it, even in America. That's why I have a lot of foreboding about bringing this up with my GI doc, to be honest.

I also checked out the Adacolumn website last night. It seems a promising treatment, especially for refractory patients, but I will never get the chance to try it, so... =/

/feeling sorry for myself

vixen
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Date Joined Jan 2010
Total Posts : 794
   Posted 9/12/2010 6:58 AM (GMT -7)   
((((hugs)))) There will always be new things coming out, hang in there!

Writer
Regular Member


Date Joined Aug 2006
Total Posts : 443
   Posted 9/12/2010 5:18 PM (GMT -7)   
Vixen,

Many thanks! I think you might actually be the first person to post the results of this study of naltrexone. This is the recently completed phase 2 study conducted at Penn State, not the pilot study published in 2007. This has some good hard data since they did biopsies before and after. A 45% remission rate is very respectable, given that it is accompanied by endoscopic improvement. This is just an abstract, so I will be eager to see the results in detail when the study is fully published. By the way, for those following the studies of this medication, the phase 2 trial in children is also complete, but I haven't seen any abstract of the results yet.

janicea
Regular Member


Date Joined Feb 2009
Total Posts : 350
   Posted 9/14/2010 7:03 PM (GMT -7)   
I'm a remission patient there, though I wasn't in the study. I've heard all the trials are going well!
strictures, crohn's, adhesions, endo. Pyoderma Gangrenosum.
LDN 4.5mg caused 100% crohn's remission.
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