Lactalose and Flare. Wellbutrin as a TNF inhibitor

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ubob
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Date Joined Dec 2003
Total Posts : 98
   Posted 1/3/2011 12:55 PM (GMT -6)   
My daughter has been on welbutrin as a TNF inhibitor for 7 years with great results, she recently went to a new doctor who put her on lactalose for a unrelated issue, one of the side effects of lactalose is severe diarrhea which put my daughter in the worst flare in over six years. She ended up on Entocort which got thing under control but resulted in 20 pounds of fluid gain this was her only time on steroids. At 19 people were asking her if she was pregnant which was devastating to her. Shes off the Entocort after two weeks and the wellbutrin is keeping things under control.
We have just seen the 5th crohns patient that we know go on wellbutrin and after two weeks shes in remission as well. Its a great drug but at $15-30 per month the drug companies would rather sell remicade.

grayeyedblonde
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Date Joined Jul 2008
Total Posts : 383
   Posted 1/3/2011 1:41 PM (GMT -6)   
This is interesting... I never knew Wellbutrin was considered a TNF inhibitor. I've worked for many years in the mental health field so I know that it is used as an anti depressant and smoking cessation drug. I will have to do some more research on this as I've failed Humira and am reluctant to try any of the other TNF's.

Thanks for the info!
Dx'd w/ Crohn's in 1979 at age 13. Bad flare 2008 but no health insurance so I dealt with it. Colonoscopy in July 2009 caused a perforated colon, emergency bowel resection. 2 fistula's, perianal and perivaginal.

Humira, probiotic, a multivitamin, Glucosamine, D3, calcium, potassium, magnesium, zinc, and fish oil. I also take Tramadol 50 mg and Klonopin (for anxiety) as needed.

Life may not be the party we hoped for, but while we are here we might as well dance!

ubob
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Date Joined Dec 2003
Total Posts : 98
   Posted 1/3/2011 2:14 PM (GMT -6)   
The most important thing to be aware of is that the sustained release does not seem to work. My daughter and the patients who have success with it typically take the immediate release at 100mg 3x/day. The difference may be the same as the difference between asicol and pentasa, the same drug but released in different areas of the gut. If you google buproprian and crohns you will find some information.

ubob
Regular Member


Date Joined Dec 2003
Total Posts : 98
   Posted 1/4/2011 6:25 PM (GMT -6)   
A couple of interesting links in relation to wellbutrin (burpropion) and crohns
hope their of interest.
http://www.disease-treatment.com/showthread.php?t=27430
http://www.psychosomaticmedicine.org/cgi/content/full/65/4/719

ivy6
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Date Joined Sep 2005
Total Posts : 10404
   Posted 1/4/2011 6:33 PM (GMT -6)   
This topic was widely discussed on the forum a few years ago. Some of the old posts have probably disappeared (we had a big server crash and some posts were lost), but you might still get some fine results if you do a forum search.
Co-Moderator Crohn's Forum.

Medications for Crohn's ~~ Diet and Nutritional Therapy for Crohn's ~~ Dealing with Abscesses and Fistulae ~~

cupcakespinkgal
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Date Joined Jun 2010
Total Posts : 720
   Posted 1/4/2011 8:16 PM (GMT -6)   
Thanks for posting this. I have been on remicade and humira and have had great success with ANTI-TNF drugs minus the side effects, which ultimately is why I stopped both. Currently I am trying alternative therapy that is supposed to help lower TNF and inflammation. If that doesn't work this may be a good option for me!

Out of curiosity when your daughter first started wellbutrin did you approach your doctor about it or did your doctor suggest this as an option?
Diagnosed with Crohn's in 1998, father has UC we were both diagnosed at 20 yrs old.

Meds ~ Sulfasalazine 2/2xday
Supps ~ Jigsaw Essential Blend Probiotics, psylium seed, SRT magnesium, D3, K2, Calcium/Boron and multi-mineral. Following modified Fodmap diet.

Previously on Remicade, stopped Humira after 9 months, wasn't working. No surgeries so far.

lady1012
Regular Member


Date Joined Nov 2006
Total Posts : 304
   Posted 1/5/2011 12:03 AM (GMT -6)   
Other uses(Wellbutrin)
Bupropion has been approved by the FDA[56] for the prevention of seasonal affective disorder.[57] According to several case studies and a pilot study, bupropion lowers the level of an inflammatory mediator TNF-alpha[58] and may be useful in autoinflammatory conditions such as Crohn's disease[58][59] and psoriasis.[60][61]

No properly controlled double-blind studies of bupropion for Parkinson's disease have been conducted. A small 1984 study funded by bupropion's manufacturer found that addition of bupropion to carbidopa or levodopa improved Parkinson's symptoms in ten out of twenty patients; however, the side effects, particularly nausea and vomiting, were frequent.[62] The American Psychiatric Association notes that, "there is no evidence favoring any particular antidepressant medication from the standpoint of therapeutic efficacy in patients with Parkinson’s disease complicated by major depressive disorder".[63]

There is considerable disagreement regarding whether it is useful to add an antidepressant, including bupropion, to a mood stabilizer in patients with bipolar depression.[64][65][66]

Bupropion, similarly to other antidepressants, is not efficacious in chronic low back pain.[67][68] However, it has been found to have surprisingly high efficacy in the treatment of neuropathic pain.[69][70][71]

Contraindications
GlaxoSmithKline advises that bupropion should not be prescribed to individuals with epilepsy or other conditions that lower the seizure threshold, such as alcohol withdrawal or benzodiazepine discontinuation, anorexia nervosa, bulimia, or active brain tumors. It should be avoided in individuals who are also taking monoamine oxidase inhibitors (MAOIs). When switching from MAOIs to bupropion, it is important to include a washout period of about two weeks between the medications.[72] The prescribing information approved by the FDA recommends that caution should be exercised when treating patients with liver damage, severe kidney disease, and severe hypertension, as well as in pediatric patients, adolescents and young adults due to the increased risk of suicidal ideation.[72]

According to a retrospective case series published in 1993, bupropion treatment may exacerbate tics in children with co-occurring ADHD and Tourette syndrome.[73] No further research of this side effect has been conducted


From Wikipedia

shiloah
New Member


Date Joined Jan 2011
Total Posts : 4
   Posted 1/5/2011 8:49 PM (GMT -6)   
I am interested in this thread on the topic of Bupoprione as a med for Crohn's.  My daughter has been taking it for approx. 4 months.  It should be taken on schedule, and at the right dosage of 300 mg instant release form.  The lower cost is a welcome relief.  We did our research before presenting the findings to our gp, and he agreed to write a prescription.  So far, so good!  It has some definite immunosuppresent properties that work well.     
Blessings to All,
Shiloah

Mother of 3 "twenty-somethings" w/ digestive issues, including Crohn's and gluten intolerance.


"Have I not commanded thee? Be strong and of a good courage; be not afraid, neither be thou dismayed; for the Lord thy God is with thee withersoever thou goest." Joshua 1:9

shiloah
New Member


Date Joined Jan 2011
Total Posts : 4
   Posted 1/5/2011 8:54 PM (GMT -6)   
Clarification: The total for the day is 300 mg. That is 100 mg - 3 X day! Just wanted to make sure I didn't confuse anyone.
Blessings to All,
Shiloah

Mother of 3 "twenty-somethings" w/ digestive issues, including Crohn's and gluten intolerance.


"Have I not commanded thee? Be strong and of a good courage; be not afraid, neither be thou dismayed; for the Lord thy God is with thee withersoever thou goest." Joshua 1:9

ubob
Regular Member


Date Joined Dec 2003
Total Posts : 98
   Posted 1/6/2011 9:37 AM (GMT -6)   
Hi Shiloh

Shilohs daughter is the six patient that I have helped get on the wellbutrin for crohns since my daughter was placed on it by Dr. Kast in 2003. All of those patients gained remission. I have seen posts in the past from people who were taking wellbutrin for depression while being treated for crohns and didn't get results; however the wellbutrin thats typically prescribed is sustained release which does not work for crohns , the immediate release is what work for crohns. Congratulations Shiloh

UBOB

cupcakespinkgal
Veteran Member


Date Joined Jun 2010
Total Posts : 720
   Posted 1/6/2011 11:52 AM (GMT -6)   
ubob or shiloah,

Have either of your daughters noticed any effects of taking an antidepressant for taking for something besides depression? Good or bad? Or just any side effects they have noticed at all?

Thank you for all your info, it really has been helpful!
Diagnosed with Crohn's in 1998, father has UC we were both diagnosed at 20 yrs old.

Meds ~ Sulfasalazine 2/2xday
Supps ~ Jigsaw Essential Blend Probiotics, psylium seed, SRT magnesium, D3, K2, Calcium/Boron and multi-mineral. Following modified Fodmap diet.

Previously on Remicade, stopped Humira after 9 months, wasn't working. No surgeries so far.

notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 10356
   Posted 1/6/2011 12:15 PM (GMT -6)   
this is so interesting to me. I wonder if it would help my UC. I'd much rather take wellbutrin than many of these other drugs.
Co-moderator: Ulcerative Colitis
03/07: Mild Proctitis | 08/08: Pancolitis! | 09/08: FLARE & Anemic Asacol (9) + Canasa | 01/10: FLARE AGAIN!! Asacol + Prednisone + Canasa | Currently: doing OK - Asacol + Canasa + Rowasa + 6mp + Allopurinol + Prednisone (tapering again...) + Ponstel + Klonopin + Ambien

ubob
Regular Member


Date Joined Dec 2003
Total Posts : 98
   Posted 1/6/2011 7:11 PM (GMT -6)   
Cupcakespinklgal The most significant side effect that my daughter had is that the wellbutrin had somewhat of a stimulative effect and she had difficulty sleeping for the a couple of months, that being said she didn't have any fatigue during the day. I asked her doctor when it would make her a more pleasant teenager and he laughed, he indicated that if she wasnt depressed it wouldnt have any effect on her mood.

Notsosicklygirl

All of my experience has been with crohns disease, that being said the treatments are the same and I would expect the results to be the same; as my daughters doctor said its a free lottery ticket and you have nothing to lose and everything to gain. you've got your whole life to try the other meds. I cant think of a drug that has so few side effects and is so inexpensive. Wellbutrin causes no long term damage that Im aware of and is safe to use during pregnancy. Let me know if you have any more questions.

UBOB

BeeSting
Regular Member


Date Joined Nov 2008
Total Posts : 392
   Posted 1/7/2011 1:27 PM (GMT -6)   
TNF or the effects of TNF are also inhibited by a number of natural compounds, including curcumin[12][13][14][15] (a compound present in turmeric), and catechins (in green tea).

From Wikipedia


I would like to try Wellbutrin myself. I have used that drug 10 years ago to manage to quit smoking, the brand name was Zyban, which is the same as Welltrubin or Bupropion. It actually helped me to quit the bad habit! And I remember that I had no side effect at all, just got my mood a bit upregulated so to speak, which was great to fight depression while having no cigarettes available ;-)...

Anyway, could any of you tell me what dose I have to suggest for my GP?

ubob
Regular Member


Date Joined Dec 2003
Total Posts : 98
   Posted 1/7/2011 6:22 PM (GMT -6)   
The dose is typically 100mg 3x/day, it is extremely important that you use the immediate release as the sustained release may actually have a negative effect. Im glad to hear that your going to try it it, so far the six people I have seen go on the wellbutrin have all gone in to remission. Keep us updated.

Ubob

cupcakespinkgal
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Date Joined Jun 2010
Total Posts : 720
   Posted 1/8/2011 10:02 AM (GMT -6)   
I have just 2 more questions, as next time I see my doc I am thinking about discussing this with him as well.

Does your daughter take Wellbutrin or a generic version? Do you know which generic version? If she has taken both did she see any difference?

Did your insurance blink at all for covering it since she has no history of depression? Do you know how much a month supply costs without insurance?

Sorry that was a few questions!!!
Diagnosed with Crohn's in 1998, father has UC we were both diagnosed at 20 yrs old.
Previously on Remicade, Humira - No surgeries so far

Meds ~ Sulfasalazine 2/2xday,
Supps ~ Moducare, Jigsaw Probiotics, psylium seed, magnesium, D3, K2, Calcium/Boron, multi-mineral. Modified Fodmap/low fructose/no sugar - Greens & seeds everyday for sterols

ubob
Regular Member


Date Joined Dec 2003
Total Posts : 98
   Posted 1/8/2011 12:21 PM (GMT -6)   
We get generic buproprian and see no difference; as far as insurance goes we dont have any drug coverage which doesnt matter any way as it is inexpensive. Shiloah told me that she pays $15 a month and I pay less that $30. Its a little bit less expensive than remicade or humara. Let me know if you have any more questions.

UBOB

IAmTheWalrus
Regular Member


Date Joined Jan 2011
Total Posts : 124
   Posted 1/8/2011 3:55 PM (GMT -6)   
Is this legit? Might say this to my GI when I see him next week or in the future. I feel like I'm almost near remission myself except for waking up a couple of times during the night to relieve myself.

ubob
Regular Member


Date Joined Dec 2003
Total Posts : 98
   Posted 1/8/2011 8:49 PM (GMT -6)   
Hi Walrus

Yes this is legit, google buproprian and crohns disease and you will find many references, the question is do the drugs companies have any desire for there to be a safe and effective TNF inhibitor out there that is under $30. The answer is no. Wellbutrin will never be allowed to become a standard treatment for crohns when you have drugs like remicade that cost $6000 per treatment. These are my personal beliefs. Wellbutrin have been miraculous for my daughter and if she stays on her meds she stays in remission. If you need someone elses opinion ask shiloah whos daughter started on wellbutrin approx 3 months ago and is in remission. As Ive said before to date I have seen six crohns patients start and gain remission on wellbutrin

God Bless
UBOB

Gumart1
Regular Member


Date Joined Jan 2010
Total Posts : 56
   Posted 1/8/2011 9:36 PM (GMT -6)   
I am very happy to read that Wellbutrin has helped a few members here, but when I googled it for Crohn's I noticed that a large study had been planned years ago but that no results were ever published. That tells me the results were not positive for the use of Wellbutrin for Crohn's; otherwise why else would they drop the results? I also flare if I have chronic insomnia, and it seems that this drug has a very high incidence of insomnia as one of it's side effects. It would make sense that an anti-TNF drug would be effective for Crohn's, and I would like to see more personal accounts of Wellbutrin's success with this disease.

BeeSting
Regular Member


Date Joined Nov 2008
Total Posts : 392
   Posted 1/9/2011 3:34 PM (GMT -6)   
UBOB, have you found anything on Wellbutrin, or bupropion that says that this medication is suppressing the immune system? I have searched and I can't find it any place.
Remicade, Humira is biologics, but still anti TNF, and as far as I know, they do suppress the immune system.

cupcakespinkgal
Veteran Member


Date Joined Jun 2010
Total Posts : 720
   Posted 1/9/2011 4:30 PM (GMT -6)   
I was wondering the same thing Beesting. If it is anti-TNF are we still immune suppressed and at risk for infections like on humira or remicade. It would make sense that it would but people take it for depression and to stop smoking and I read the patient insert and there are no warnings of increased infection.
Diagnosed with Crohn's in 1998, father has UC we were both diagnosed at 20 yrs old.
Previously on Remicade, Humira - No surgeries so far

Meds ~ Sulfasalazine 2/2xday,
Supps ~ Moducare, Culturellle, psylium seed, magnesium, D3, K2, Calcium/Boron, multi-mineral. Modified Fodmap/low fructose/no sugar - Greens & seeds everyday for sterols

ubob
Regular Member


Date Joined Dec 2003
Total Posts : 98
   Posted 1/24/2011 8:12 AM (GMT -6)   
Gumart1 You indicated that when you dont get enough sleep you flare, wellbutrin does act as a slight stimulant and may make sleep somewhat more difficult for shrCome people, however acting as a TNF inhibitor it should put the crohns in remission. I believe that you stated you want to hear from more people who tried this, I can only tell you that the six people that I have helped start on this have all gained remission and that I have not seen anyone who has not gained remission. Others have asked if it acts as a immune suppresent and I can only tell you that I have not seen a increase in illness in the people that I know who have used this therapy. I truly believe that with this therapy you have nothing to lose and everything to gain .

Good luck UBOB

ubob
Regular Member


Date Joined Dec 2003
Total Posts : 98
   Posted 1/24/2011 6:45 PM (GMT -6)   
Gumart1 you had mentioned the research study that was done a number of years ago that did not release any results and therefore you anticipated that the outcome of the research was bad. Often just the opposite is true, an example that I saw recently came from a patient referred to my office by a neurosurgeon for decompression therapy. The neurosurgeon had been associated with a very prestigious hospital and was conducting research on decompression for spine injuries. The research demonstrated that decompression was very successful in treating disk injuries, as a result of the sucsess the study was discontinued before it ended and the research was buried. The reason for this is that decompression competed with surgery that is very lucrative for the hospitals and would have eliminated the need for surgery for many patients. The neuro quit her position at this hospital out of disgust and is now in private practice in another city. Drug companies that are performing research are under no obligation to publish a study that they have done. If they perform a study that negatively impacts their product why would they release the study; often the study is redone under different parameters in order to provide a more positive outcome for the particular drug. In regards to the wellbutrin study, I believe that the funding came from glaxo who originally produced the wellbutrin I believe. If the wellbutrin trial was successful would it have competed with a drug that was more lucrative for them. Most TNF inhibitors cost thousands/month. Wellbutrin is cheap and I could understand that if the study was successful that they may have very well buried it. Im not a pessimist but I am a realist.
UBOB

ubob
Regular Member


Date Joined Dec 2003
Total Posts : 98
   Posted 2/1/2011 4:18 PM (GMT -6)   
Beesting I'm curios as to whether you've had the opportunity to try the wellbutrin, If you have Id like to hear your results goo or bad!

UBOB
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