Fidaxomycin versus Vancomycin for C-diff infections

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PV
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Date Joined May 2006
Total Posts : 1158
   Posted 2/2/2011 5:06 PM (GMT -6)   
In the news today:
www.medpagetoday.com/InfectiousDisease/GeneralInfectiousDisease/24661

Just FYI. I think Fidaxomycin because it is a more narrow spectrum antibiotic than vancomycin will be much friendlier for people with crohn's.

PV

IamCurious
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Date Joined Jan 2010
Total Posts : 2300
   Posted 2/2/2011 7:04 PM (GMT -6)   
The problem with antibiotics is that even though they kill bad bacteria like C Diff, they also kill the beneficial flora. Then the C Diff can reappear when the course of antibiotics ends because there are no longer good flora to compete against.

Saccharomyces boulardii is a probiotic yeast that is immune to antibiotics. It is one of the beneficial flora. Research shows that it is one of the most effective probiotics targeting C Diff and keeping it from reinfecting the intestine. You can buy it by itself or under the brand name Florastor.

It may be a good idea to also include a more conventional probiotic to recolonize the good guys in your gut and not allow room for the bad guys to take over again. You can never have too many probiotics. That should help prevent future C Diff infections.
Male/59 DX ulcerative colitis Feb08, possible Crohn's colitis DX Mar10.
No Meds, allergic to Mesalamine. Remission since Mar10. Food journal instead of SCD. Psyllium seed + VSL3 especially helpful.

Boswellia, E. Coli Nissle (Mutaflor), turmeric, fish oil, S. Boulardii, OLE, resveratrol, multivitamin, extra D3, K2, C, high gamma E, magnesium, phos choline, glutamine. Lots of vegetables & fruit (but no plums), no soda, no HFCS, no trans fat, no shellfish, tea instead of coffee, watch gluten, few processed foods, no carrageenan.
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stkitt
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   Posted 2/2/2011 7:21 PM (GMT -6)   
Vanco can be tough on the kidneys thus pharmacy calculates your dose each day according to your lab results.  Hubby was just on Vanco.
 
Take care,
 
Kitt
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Ides
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Date Joined Nov 2003
Total Posts : 6818
   Posted 2/2/2011 7:22 PM (GMT -6)   
BabeintheWoods - according to the research Fidaxomicin preserves the normal gut flora. When I took vancomycin for my C. diff infection, I also had to take Culturelle to combat the diarrhea caused by the vancomycin wiping out all my good flora. I continued the Culturelle AFTER I finished the vancomycin. After the third day, I developed severe diarrhea and incontinence. At the suggestion of one of the members here, I stopped the Culturelle and my bowel function returned to normal.

PV - Thanks for bringing this information here. It's good to know there is something new in the works to deal with C. diff. My experience with C. diff caused me to be hospitalized with severe hemorrhaging colitis and a spontaneous prolapse of my pelvic organs necessitating surgery.
Vancomycin did not get rid of my C. diff. A 14 day course of Xifaxin did get rid of it. I hate C. diff!!!!
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PV
Veteran Member


Date Joined May 2006
Total Posts : 1158
   Posted 2/2/2011 10:04 PM (GMT -6)   
Actually my husband does take florastor (250 mg - 4 caps daily) and 2 cups of homemade yogurt and 2 packets of vsl3. Despite all this my husband has trouble with cdiff on occasion and vancomycin does wipe out all your gut flora including the good stuff. This is why fidaxomicin is better. It is not as broad spectrum as vancomycin thereby reducing the amount of good bacteria that gets killed along with the bad. Also with vanc you have the possibility of VRE which us scary.

I think the more drugs we have to fight cdiff the better. Based on my hubby's experience, you can have trouble even doing all the right things. And he is very good about his diet as well. He hasn't had anything sugary in over 5 years, cut out caffeine entirely and eats a very conservative diet and takes florastor and vsl3 and yogurt.

PV

Crohnie4Life
Regular Member


Date Joined Jan 2010
Total Posts : 69
   Posted 2/16/2011 9:08 PM (GMT -6)   
I have C Diff now. Sucks. On my second round of vanc. This round lasts 26 or 28 days. I should be adding Floreaster soon. I'm too broke to get it now.

I was just talking with my wife about what would happen if this round was unsuccessful. I knew there was another drug out but didn't know it was only a study. Thanks for the article!
Crohn's Disease and Bipolar Disorder laced with wicked Panic Attacks. !YAY!
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