Fecal transplant for Crohn's

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jpnutritionfirst
Regular Member


Date Joined Apr 2009
Total Posts : 362
   Posted 4/15/2013 8:35 PM (GMT -6)   
Hello, I know this has been addressed before and I have read the prior posts, but I wanted to get an updated thread posted here.

Is there anyone out there who has tried fecal transplant for Crohn's? If so what has been your experience and what have been your results?
I understand that conventional medicine is only using it for C diff right now but some doctors are actually using for IBD, but mostly for UC (http://fecalmicrobiotatransplantation.com/FMT/home.html). There are actually people doing this at home completely on their own (plenty of videos on youtube with seemingly miraculous results). Like anything else, I'm sure this probably won't work for everyone. It seems like most of the research being done now is for UC rather than Crohn's.
Crohn's diagnosed 6/08
SCD since 4/09
LDN since 7/5/10
vitamin D 5000IU + sulfasalazine 2grams daily + lactobacillus
Remicade from 6/09 to 4/10
Low-dose naltrexone 7/5/10 -
boswellia 3/09 to 5/12
hookworm therapy 12/12 to 4/12

georgie_girl
New Member


Date Joined Oct 2010
Total Posts : 11
   Posted 4/16/2013 5:57 AM (GMT -6)   
Check out Genevieve's Story http://thepowerofpoo.blogspot.com.au/2012/12/genevieves-success-story.html

NY-Sooner
Regular Member


Date Joined Sep 2009
Total Posts : 409
   Posted 4/16/2013 2:24 PM (GMT -6)   
The SCD diet does the same thing as the fecal transplant does.  The diet kills all the bad bacteria and yeast in your gut by starving them to death by depriving them of the sugar and carbs they feed on.  Then by eating home made yogurt you repopulate your gut with good healthy bacteria.  Same as fecal transplant.  

jpnutritionfirst
Regular Member


Date Joined Apr 2009
Total Posts : 362
   Posted 4/16/2013 2:54 PM (GMT -6)   
Well I don't think it's the exact same thing. SCD is a long process and a difficult diet to follow for many including myself. I have been on SCD for 4 years (strictly compliant) and it has helped but hasn't completely gotten me back to being 100% (as evidenced by my recent colonoscopy). Anyway, it seems like a fecal transplant would be a much easier and definitely much faster way to address the underlying pathogenesis of inflammatory bowel disease compared to waiting several years for SCD. In my opinion I think fecal transplants are the future and should be a key area of interest for the CCFA if their goal really is to find a cure to the disease.
Crohn's diagnosed 6/08
SCD since 4/09
LDN since 7/5/10
vitamin D 5000IU + sulfasalazine 2grams daily + lactobacillus
Remicade from 6/09 to 4/10
Low-dose naltrexone 7/5/10 -
boswellia 3/09 to 5/12
hookworm therapy 12/12 to 4/12

killcolitis
Veteran Member


Date Joined Dec 2009
Total Posts : 2396
   Posted 4/16/2013 3:37 PM (GMT -6)   
Look at Sky Curtis's website. She treated her son's CC with long term FT protocol and he was very severe. Don't go by her 100% cure rate but she did do it. I think it's well worth a shot.

beachlife
Regular Member


Date Joined Feb 2009
Total Posts : 464
   Posted 4/17/2013 1:01 PM (GMT -6)   
yes, lots of positive stories, check out this excellent resource: http://thepowerofpoo.blogspot.com/p/success-stories.html

join the conversation with others who have done, are currently doing, or strongly thinking about FT
https://www.facebook.com/groups/thepowerofpoop/
/www.facebook.com/groups/thepowerofpoop/

Osprey101
Regular Member


Date Joined Apr 2008
Total Posts : 227
   Posted 4/20/2013 12:07 PM (GMT -6)   
I've been on the SCD (which turned into a low-carb, grain-free diet with plenty of Gottschall yogurt) for 5 years. I have no symptoms, unless I screw up and eat the wrong thing. I can go months without so much as a twinge.

But, working with patients like I do, I got concerned what would happen if I came down with C. diff. So, while my half-sister was visiting, I asked that she give me a sample so I could freeze it in the event I came down with C. diff. She and I share a mother, so whatever inoculum she received at birth has done well by her as neither she nor her kids have any signs of digestive disorders- although I kind of worry about my niece.

Anyway- by the time I got the sample, I found out my information was wrong, and freezing would almost certainly decimate whatever live flora would be in there; long cold storage would be even worse. So- I thought, what the heck; I might never get this chance again. I prepared the sample in a HEPA-filtered workspace using sterile tools and aseptic centrifuge tubes. I didn't use a blender; I used a vortexer to homogenize the samples- there is probably no real difference between the two. The sample was prepared in sterile normal saline, and put where the sun don't shine using a cleaned enema bottle. I did the best I could to invert myself for ~5 minutes after inoculation. Due to my low-carb diet, I did not excrete for about 36-48 hours afterward.

There were no specific changes. However, I did a "challenge" consisting of turmeric in water; turmeric has always been a weak spot for me. Before I got sick- no problem. After my diagnosis, the tiniest trace of turmeric would set me into a series of hiccups that would last for half an hour. I had insufficient time to test whether this was still the case immediately before inoculation.

However, *after* inoculation, I found I could tolerate multi-milligram doses of turmeric with absolutely no problems. I cannot positively attribute this to the "transplant," as I have serious doubts as to how flora in the lower colon (i.e., the inoculum) affect what's going on in the small intestine (i.e., the furthest any turmeric could possibly have gotten in the time it takes for hiccups to develop).

OTOH, the smell of my feces changed; there definitely was a change in micobiota going on. Now, several months later, the smell is back to what it used to be- most of the time. There are presumably some permanent changes in terms of diversity.

It is extremely important to note that once you lose flora, you're probably not getting it back. Whatever it is you're born with- perhaps 800 different species- is gradually winnowed away, a function of antibiotics, the lack of lactic acid fermented foods in the diet, the relatively clean water and food we consume these days, and so forth. You don't get these back, and when you have children (usually in a nice, clean hospital) this changes even further.

This may be one explanation as to why the incidence of these disorders continues to climb: antibiotic administration, and cumulative loss of diversity as a function of environmental factors.

Be good to your gut flora. Successive generations will thank you.

pmedic
Veteran Member


Date Joined Nov 2009
Total Posts : 1420
   Posted 4/20/2013 6:43 PM (GMT -6)   
Try posting this over on the UC forum. They have been very active for using FT.
Dx:Ulcerative Colitis March 2008
Dx: Crohns May 2008
Avascular necrosis bilateral knees from Prednisone. Surgery on left knee was Oct 2011,
No colon surgeries yet but I am desperately trying to keep my colon.
8 blood transfusions, SVT due to low H&H, Anxiety during new medication injections due to past reactions.
Currently on Lialda, Ambien, xanax(prn) D3, probiotic, Rowasa, B12, fish oi

jpnutritionfirst
Regular Member


Date Joined Apr 2009
Total Posts : 362
   Posted 4/21/2013 10:36 AM (GMT -6)   
that's precisely why i'm confused that fecal transplants are bigtime in UC but hardly even mentioned for Crohn's disease. To me, Crohn's is more microbiota driven than UC. Elemental diets work only in Crohn's and not in UC and the mechanism there is changing the microbiota. Also the use of antibiotics is more well established in the treatment of Crohn's flares rather than in UC. I think fecal transplants would be more effective for Crohn's than UC. More people here should try it. I'm reluctant to jump into new things anymore since I got burned trying hookworm.
Crohn's diagnosed 6/08
SCD since 4/09
LDN since 7/5/10
vitamin D 5000IU + sulfasalazine 2grams daily + lactobacillus
Remicade from 6/09 to 4/10
Low-dose naltrexone 7/5/10 -
boswellia 3/09 to 5/12
hookworm therapy 12/12 to 4/12

scifigal2k
Veteran Member


Date Joined May 2012
Total Posts : 1129
   Posted 4/21/2013 11:33 AM (GMT -6)   
Part of it is because Crohn's can be throughout the entire digestive tract (and even further with fistulas), while UC is localized. And at least for me, antibiotics make everything much worse.
CD 2010, Fistula, Pancreatitis, C. Diff.
Current: Remicade
Previous: Prednisone, Imuran, and Asacol

"These things I have spoken unto you, that in me ye might have peace. In the world ye shall have tribulation: but be of good cheer; I have overcome the world." John 16:33

crohnscait
New Member


Date Joined Apr 2013
Total Posts : 1
   Posted 4/23/2013 4:33 PM (GMT -6)   
I had recurrent c. diff infections for which I received a fecal transplant 2 months ago. I also have Crohn's, and I was hoping that it would help with this disease as well. While it has finally(!) cured the c. diff, I am currently having the worst flare of my life. In other words, it did nothing to help treat, much less cure, the Crohn's.

wadsworth
New Member


Date Joined May 2013
Total Posts : 1
   Posted 5/21/2013 7:04 AM (GMT -6)   
HEllo,
New here,
Crohns in full remission since 2004 fistula surgery.
I am on remicade & azathioprine and was researching into Fecal transplants as a way to possibly get off meds.
I have read many of the posts over the years and keep reading people eating yogurt and dairy.
I believe the research that says this is a big NO-NO.
I feel the Crohn's bacterial infection is derived from the MAP bacteria in dairy and often relapse are associated with people re-infecting themselves after they are cured! This is the same as the Johne's disease in cows, it survives american processing standards and we get it in our foods.
There is plenty to eat out there - don't eat ANY dairy, why risk it! There is some evidence it turns up in meats as well.
I have been vegan for over 10 years and i attribute my remission to that.( i believe i ingested the bacteria before or early on when i was new at being vegan and didnt know what i was doing) Also i don't eat much sugar and no simple carbs. Sounds awful when i write it out but i love to eat and generally i eat a great healthy delicious diet. I'm not sure if the meds cured me and i have just not re-infected myself or if the diet allowed healthy bacteria to thrive or what. I want off my meds but would like a way to monitor myself after a transplant to see if it is safe to stop remicade. I hate to just stop and see if symptoms occur, there is research suggesting the body is less receptive to remicade after it has been stopped.
Just wanted to contribute my story to the mix...
Best wishes everyone
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