Missing a dose?

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not creative
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Date Joined Mar 2007
Total Posts : 469
   Posted 9/26/2017 12:25 PM (GMT -6)   
So, due to my recurrent staph infection, I have been advised not to take my 6MP and Simponi until the infection is gone and doesn’t come back. My GI said it could make me worse if I took it. I am being seen by Infectious Diseases tomorrow morning. In the meantime, today is the day I was supposed to inject my Simponi. So, I will be missing/skipping this dose and I’m terrified that the Crohn’s is going to come back. I’ve heard that stopping and starting biologics can reduce their effectiveness. I have tried everything but Entyvio and I’m worried that even delaying by a week could cause me to come out of remission.

I’m not sure if I’m worrying needlessly (not that that isn’t my thing, I worry a lot). I’ve been in remission with the Simponi and 6MP for years now, I don’t have much more colon to give to this disease. Anyone miss/skip a dose of their biologic for whatever reason? Would you mind sharing how that went?
Crohn's, Fibromyalgia
3-9-10: Total proctectomy and Sigmoid colostomy
On: Simponi, 6MP, Cymbalta, , Gabapentin, doxy (rosacea), synthroid, iron, multivitamin

Veteran Member

Date Joined Mar 2007
Total Posts : 1741
   Posted 9/26/2017 4:59 PM (GMT -6)   
I can only say that missing the 6mp isn't a big deal. Even if you have to stay off of it for a week or more.

With biologics, you usually want to stick to a regular schedule, but many have had to delay a dose due to infections. I'm not sure if there's any information out there to indicate how long you have to be off of a biologic before running the risk of developing antibodies.

Hopefully somebody can chime in on that, and also hope you're feeling better soon.

Forum Moderator

Date Joined Nov 2003
Total Posts : 7116
   Posted 9/29/2017 4:22 PM (GMT -6)   
I took Simponi for 9 years and had to miss doses two different times for major surgeries. The longest overdue period I had was 6 weeks. [Mind you - I took Simponi every 3 weeks] I never had issues with the Crohn's flaring up, though my ankylosing spondylitis got worse.

I wouldn't worry if you have to delay for a round of antibiotics. Simponi won't lose effectiveness with a short delay.
Moderator Crohn's disease, Osteoarthritis and Irritable Bowel Forums

CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, pulmonary hypertension, degenerative disc disease, asthma, severe allergy and a host of other medical problems.
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