Neurotoxicity with Glutamine supplementation

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xy123
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Date Joined Feb 2014
Total Posts : 659
   Posted 9/30/2017 8:20 AM (GMT -6)   
Many of us know that L-glutamine has been used as an additional tool to treat IBD. (Just google "glutamine crohn's colitis pubmed" to see some of the papers)

Although This new Cochrane review says:
review said...
Currently there is insufficient evidence to allow firm conclusions regarding the efficacy and safety of glutamine for induction of remission in Crohn's disease. Data from two small studies suggest that glutamine supplementation may not be beneficial in active Crohn's disease but these results need to be interpreted with caution as they are based on small numbers of patients. This review highlights the need for adequately powered randomised controlled trials to investigate the efficacy and safety of glutamine for induction of remission in Crohn's disease.


Anyways...

I bought l-glutamine supplements to try it out; but then I've found some links between glutamine and neurotoxicity:

onlinelibrary.wiley.com/doi/10.1002/hep.21357/pdf
forums.phoenixrising.me/index.php?threads/glutamine-is-harmful-relationship-with-ammonia-and-astrocytes.38680/
/www.ncbi.nlm.nih.gov/pmc/articles/PMC4714775/
/www.ncbi.nlm.nih.gov/pubmed/11754523

/www.ncbi.nlm.nih.gov/pubmed/2566647

What do you guys think?

Do you think it is safe to supplement with L-Glutamine?
The dosage used to treat IBD is generally higher (around 30 grams/day) than the doses used for the purpose of physical training and muscle gaining etc...

Thanks.

Edit: This is the new Cochrane review: onlinelibrary.wiley.com/wol1/doi/10.1002/14651858.CD007348.pub2/abstract
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