I had a huge reaction to Imuran. And my doctor denied me too. I found out years later, when I was being interviewed for the human genome IBD project, that I was not alone, that was easily 4 years after the fact. (Man, if I had had the internet then...)
My stomach was already killing me, duodenal & small bowel, CD. So even though it killed, I didn't complain about
the pain -- too inured to it, and had crappy doctor's who ignored my pain. I did complain about
two weeks my knees started aching and every time I stood up, it felt like I'd lost all the soft tissue in my knees, and it was bone on bone-- breathtaking pain and I became achy all over. I talked to the, ahem, doctor, as I was feeling worse and functioning less.
I rode it out some more.
a month into it, I could barely get out of my house and I then got a funky fever. I was taking my dose in the morning, by dinner the fever would be up. The interesting part, was that it would break in the very early morning.
The next few days went like this Day 1, 100 Day 2, 101, Day 3, 102... this continued until the day I got up to 107 (I was 29 years old).
I was living alone and got in the habit of walking around with my non-cordless phone. Thank God I did.
I had just started antibiotics on my GI's request. She decided I had the flu.
The last day I took my almost last Imuran, my fever was at 107 by 3 in the afternoon. I went to lay down and was on my stomach. I realized I had forgotten to take the anti B, and tried to get up. Every muscle attached to my spine, from my neck to my tail bone seized at once. I have never, not from broken jaw or Crohn's screamed so loud in my life.
And I had to call someone to come
open my apartment door and I called an ambulance, I also passed out for the first time in my life -- after 8 years of CD. I think I held on pretty well!
Still my GI decided that this was not a reaction to Imuran but some bug. I tried it again, 4 months later, at her insistence. My knees went after 3 days. I stopped it. I had all the information I needed. I cried for a week after that. There were no other drugs for me to try and the GI decided that I was not being compliant, yes I eventually fired her.
Sick as I was before that, it took me a year to get out of my home and back to work.
Imuran can be too much for some of us, of this I am certain.
CD 25 years. Multiple surgeries in past 10 yrs. 4 year Illeostomy and looking down the barrel of another (fistulas due to surgery, not CD) . Mesh rejection. Large incisional hernia. Perpetually underweight. Short bowel syndrome. Have used a variety of complementary medical therapies. Highly recommend Bowen Therapy as the best body work. Take me vites. Started Low Dose Naltrexone March 27, 201
Post Edited (MToronto2) : 6/2/2012 12:06:13 AM (GMT-6)