Need help with side effects of prednisone

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ProfCrohny
Regular Member


Date Joined Sep 2007
Total Posts : 44
   Posted 9/7/2007 9:56 PM (GMT -7)   
I was just diagnosed with Crohn's and I'm currently on 2.5 20 mg of prednisone (being tappered weekly). It's been pretty awful with really painful swelling, insomnia, mood swings, acne, etc. Does anyone have any advice for how to attenuate some of these side effects? I know about changing to a low sodium diet and I've been trying to read about it, but any additional advice would be really great. Thank you so much.

teddybearweiser
Veteran Member


Date Joined Oct 2004
Total Posts : 3042
   Posted 9/8/2007 2:47 AM (GMT -7)   
Hi LME,
Welcome to Healing Well. Prednisone is known as the evil drug because of the side effects.
Once your off pred it takes awhile to get out of your system. Thats why I don't let the doctors
put me on pred. because of the side effects.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital
in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.
 My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
My Internest doctor has me on Lisnopril-HTCZ and Folic Acid. Diagnosed
with Osteoarthritis July 2007
 


EMom
Veteran Member


Date Joined Aug 2007
Total Posts : 990
   Posted 9/8/2007 5:24 AM (GMT -7)   
Welcome, LME. I was wishing there was something earlier in the summer for my son's side effects from Prednisone. I don't think there is anything. Then I was wondering how long the effects would last once the pred. was finished. about two weeks after he finished the pred. his swollen face looked a lot better. The mood swings left around that time, too (thank goodness! I felt like I had someone else's kid in my house!). The acne has hung on but looks waaayyy better. (he had beautiful skin before all this) He has now been off pred. for 4 1/2 weeks. He also states he will never use that stuff again. Hopefully we'll never have to. I hope this little bit of info helps! Good luck to you!
EMom

Mother to 15 year old boy just diagnosed in June, 2007. Taking Asacol, just finished Prednisone, omega 3s, digestive enzymes, probiotics, iron, vit. C, and a good multivitamin.


Zanne
Veteran Member


Date Joined Apr 2005
Total Posts : 3763
   Posted 9/8/2007 7:31 AM (GMT -7)   
I have a love/hate relationship with prednisone. It can make us feel so much better quickly, but the side effects, both short and long term can be horrible. As far as the insomnia, ask for a sleeping pill. Your doctor should have no issues Rxing something. Once the dose gets lower, you won't need it. But your body can't heal if it can't sleep. Also, for the anxiety/jitters ask for a mild tranquilizer. Once again, your doctor shouldn't give you any grief about this. And once again, when you get lower, you won't need it. The bloating/moon face not much you can do except live with it. You need to ask for and demand relief from your doctor. If you just mention the side effects in passing, the doctor won't really take it seriously. But there really are things that can be done to at least make you a little more comfortable, but you need to ask forcfully!

Also, no matter how long you are on prednisone, please increase your calciumn intake. It can eat away at your bones and you don't want to take that chance. I had my first compression fracture at 30 and will have osteoporosis for the rest of my life because of prednisone. No one told me to take calcium.
Suzanne

CD 19 years offically, 29 unofficially. 3 resections '93, '95 '97
Symptoms constantly but all tests show only minor ulcerations. Currently having multiple episodes of gastritis with no known cause.


Prednisone, 6MP,Prevacid, B12 shots, Bentyl, Xifaxan.....


Beth75
Veteran Member


Date Joined Jul 2007
Total Posts : 2142
   Posted 9/8/2007 8:29 AM (GMT -7)   
dropping by..........

Hi I am new to prednisone, too, just started it yesterday. I have a kidney disease which I beleive is from a hypersensitivty to 5ASA drugs and this is the only way to hopefully put it in remission.

What my Doc told me is I will likely gain 10 to 20 lbs and all the other scary side effects. But I will lose 10lbs from water weight from my kidney disease. I had put on weight since getting married and really can't afford to buy more new clothes..........anyhow my Kidney Specialist told me to do a low carb diet, avoiding refined carbs such as white pasta's and to have wheat pasta's instead and have less than 1500mg of salt a day (for my kidney's too) and low sugar diet (I am not a big sugar person so that is easy).

I'm supposed to be on 60mg of pred for 1-2 mos then taper it for 4-5 mos and will hopefully be in remission and it will help my colitis flare up too.

Hope your symptoms are not too bad. Also my doc put me on fosomax to help keep my bone density and I am already on 500mg of calcuim + vit D 2xday.
Beth, 31
UC Diagnosed March 2000
Lialda 2.4mg 1xday since 8/24/07 (prev. Asacol 4800mg day),Calcium and Vit D 500mg 2xday.
Minimal Change Disease (Kidney Disorder) Diagnosed Sept 2007
Prednisone 60mg 1xday, Simvastatin 20 mg 1xday
Diovan 80mg 1xday. Fosomax 1xweek 70mg. MCD may be from hypersensitivty to 5ASA drugs.


miraclesivseen
Regular Member


Date Joined May 2007
Total Posts : 169
   Posted 9/8/2007 3:00 PM (GMT -7)   
I too had a love hate with prednisone, it was the only thing that worked and worked fast, but the side effects are awful.
The moods swins were the worse, I was also ver low on thyroid meds due to too many bm's so my emotions were wacked. And I still have trouble sleeping, but I was on pred., on and off for over 7 years.

I can't tellyou how many times I left the house to go run errands and had to turn right around and go back home, I was so impatient, and high strung, I didn't need to be in public lololol.

The weight gain didn't help either, I blew up to almost 200 #'s I am 130 now, But if my Crohns was causing pain then 200 #'s was worth it, I was very fluffy on pred.
Brain tumor 1981
Dx.Crohns disease 1996
bowel resecction 2001
Thyroid cancer 2001
breast cancer .....currently waiting treatment options
seizure disorder .....all my life.
 
 
 
 
 


Mac_Gyver
Regular Member


Date Joined Aug 2007
Total Posts : 350
   Posted 9/8/2007 7:54 PM (GMT -7)   
I have the appetite effect of predisone, which is good, I need to get another 15lbs on me. Acne on the arms and face though I could deal without
Symptoms Of Crohn's June of '06 (21 years old 285lbs). Colonoscopy in Jan '07 no sign of Crohn's.
Surgery for a Fistula in April '07, diagnosed suggestive Crohn's in May '07. August '07 small bowel follow
through, diagnosed with Crohn's (22 years old 160lbs). On HUMIRA, Prednisone
myspace.com/finalmacgyver


gachrons
Veteran Member


Date Joined Mar 2007
Total Posts : 4527
   Posted 9/10/2007 7:07 AM (GMT -7)   
Hi My glucose has gone up some so thinking that might contribute to the ups and downs it is taking me some time but now I am working my way off it I have been on it since Jan. So oh happy day when I do get off it .I read the forums a lot here to help me with the hyper end and I used to get up 3 or 4 in the morning thank goodness that has stopped. Hope you do well and welcome to HW we need all the Cder's we can get it helps so very much. lol gail

I Gotta Go
Regular Member


Date Joined Sep 2007
Total Posts : 44
   Posted 9/10/2007 8:32 AM (GMT -7)   
Yes, see if your doctor will prescribe a sleep med. like Trazadone (a non-habit forming and inexpensive sleep aid) and an anti-anxiety med. like Ativan for during the day (don't take both at night time). I also hope you're on Prilosec or Prevacid for your stomache while taking Pred. And make sure you are exercising as well.

ProfCrohny
Regular Member


Date Joined Sep 2007
Total Posts : 44
   Posted 9/14/2007 10:38 PM (GMT -7)   
I just wanted to thank everyone for their responses. Being on prednisone and getting diagnosed with Crohn's last month has been really hard, so I truly appreciate the help. I also did some reading and I think some of my side effects on the prednisone were worsened because I'm also taking a birth control pill, which apparently decreases the excretion of prednisone leading to elevations of the medication in the blood. Prior to starting prednisone, I asked my doctor about being on birth control and he never mentioned any interactions with prednisone, even though it's one of the primary interactions. I guess I just have to ride it out until I've completed tapering off of the med, because it seems like a bad idea to abruptly stop my birth control. I'm so weak that I can hardly walk a block and I go through periods of my hands uncontrollably shaking, but I'm hopeful that it will get better soon. It did really help to decrease my sodium intake. I can't tell if decreasing my carbohydrate intake is helping yet, but I think it will, because my glucose levels are very elevated right now (I had to go to the ER on Monday and they checked the levels). Thanks again for all of the support and advice. I really appreciate it.
Female, 30. Diagnosed August 2007 with Crohn's Colitis, but diagnosis is not complete, yet. Asacol 800 mg 2x day. Prednisone 45 mg (tapering). Calcium, Trinity (probiotics), and multivitamin.


paladin
New Member


Date Joined Sep 2007
Total Posts : 12
   Posted 9/17/2007 8:44 AM (GMT -7)   
I have some questions about prednisone withdrawal, and hope someone can help me.  My 78 year old mother has been on and off prednisone for about 8 years for emphysema.  This past year she had a lung abcess on top of her COPD. Doctor had her on 40 mg in hospital and reduced her to 20 mg when he released her last Sunday.  He also had her on two antibiotics, which he cold turkeyed on Saturday because she was doing so well.  On Monday we found ourselves in the ER.  She was unable to get out of bed on Monday morning and her blood pressure was 183/70.  My mother NEVER had high blood pressure before.  Went to doctor on Tuesday. Put her back on Levaquin, and she improved somewhat.  Put her back on prednisone on Friday (40 mg - 4 days, 30 mg - 3 days, 20 mg - 3 days, 10 mg - 3 days) to try to get her back to where she was when she got out of hosptal. Well, it worked.  She was great Thursday and Friday - but Saturday and Sunday she was shakey and weak with a "fuzzy head."  Also complained of cramps in her legs.  She had just finished taking the 30 mg and was starting 20 when this happened.  I have been reading other posts about prednisone withdraw, and I think that the blood pressure spike and her shaking, weakness and fuzzy head have been caused by her going off prednisone.  I have told her what I have read, and she is thinking of going back on 30 mg for a few days then cutting down to 25 mg, 20mg, etc until she gets to 10.  Any comments or ideas would be really appreciated.  Thank you.

ProfCrohny
Regular Member


Date Joined Sep 2007
Total Posts : 44
   Posted 9/17/2007 9:04 AM (GMT -7)   
My shaking and weakness has been a side effect of the prednisone, not a result of tapering. Prednisone has a lot of systemic effects on the body, including making it very difficult to break down glucose, which can lead to diabetic levels of glucose (mine are at 170 right now, which apparently is normal for someone on prednisone). Nevertheless, it's weird that her doctor tapered her from 40 to 20. That's a pretty drastic dose reduction. I went from 40 to 30, which I have to stay on for a week until I go down to 20. The tapering should occur very slowly in order for her adrenal cortex to return to normal functioning (prednisone mimics a hormone in the body called cortisol, which is released from the adrenal cortex). Anyway, I'm not an M.D. (although I am a Ph.D. who studies the effects of cortisol), but I think she should get off of the prednisone by tapering slowly, although I have no idea how prednisone is involved in emphysema. Also, make sure she decreases her sodium intake, as well as her carb/sugar intake. I had very painful swelling in my face and body, because prednisone leads to water retention (which could also affect her blood pressure), but once I cut down on sodium that went away. She should definitely get her sodium, glucose, and thryroid functioning checked. Also, prednisone leads to inhibition of proinflammatory cytokines, which are hormones of the immune system that are critically involved in antiviral responses; therefore, she's more susceptible to infection right now. So, looking for a secondary infection could be useful, as well. Also, is she on estrogen replacement? Estrogen inhibits the excretion of prednisone, which leads to elevated circulating levels and, therefore, more side effects. I'm on birth control and wasn't told about this. I actually knew it from my research, but stupidly forgot and now I'm suffering the consequences. Hope this helps. I'm super shaky and weak on prednisone right now, but it's definitely a side effect of the med.
Female, 30. Diagnosed August 2007 with Crohn's Colitis, but diagnosis is not complete, yet. Asacol 800 mg 2x day. Prednisone 45 mg (tapering). Calcium, Trinity (probiotics), and multivitamin.


paladin
New Member


Date Joined Sep 2007
Total Posts : 12
   Posted 9/17/2007 9:44 AM (GMT -7)   
Thank you for the information. I just spoke to my mom a few minutes ago, and she is feeling alittle better today. She went back up to 30 mgs. yesterday, and is going to continue that for three days, and then go to 25mgs, etc. I have read several posts where doctors were keeping them on level does for a week, then cut it 10 mgs for a week, etc. Perhaps going for four days and then cutting it by 10mgs was just too much for her. I hope this works. Again, thanks for your help.

gachrons
Veteran Member


Date Joined Mar 2007
Total Posts : 4527
   Posted 9/18/2007 5:21 AM (GMT -7)   
Hi I have emphysema am on pred. for CD and I cut back very slowly a half of a 5 mg. tab a week.My GI said I must cut back slowly .I am doing good on that cut back doseage .Hope your Mom feels better soon. lol gail

paladin
New Member


Date Joined Sep 2007
Total Posts : 12
   Posted 9/18/2007 7:05 AM (GMT -7)   
That is what she is going to do. She popped it back up to 30 mg yesterday and feels somewhat better. Is going to do 30 mg for a couple more days then go to 25, 20, 15, 10 until she gets to the 5 maintenance dose. Thanks for your help.

OldieM
New Member


Date Joined Jan 2014
Total Posts : 11
   Posted 1/22/2014 10:32 AM (GMT -7)   
having today joined the forum have been pleased to read about side effects of prednisolone...I am 78 years of age sufer from osteoarthritis, also diverticulitis....I was referred to a respiratory consultant...she has been thoroough with tests.......I have had airborne allergies all my life, and managed to live with it fairly well, but last few years different story. having been referred to a Respiratory consultant...only found borderline asthma...but breathing issues very difficult at times....CT scan revealed small nodule plus inflammation on the lung, so prednisolone for 3 month trial...first month 30mg/day started 20th Dec/13 final two months on 20mg/day....26th Dec.husband called paramedics as had severe reaction to something, swollen mouth, redface, red rash all over etc....obviously some allergic reaction to something, thought not to be the prednisolone as 6 days after starting....antihistimines cleared that..probably cleaning fluids I had used as most have perfume in..discarded the lot...ok...then a few days later real hyper active brain, everything wanted to do twice as fast etc....and a couple of times since seen doc...but they insist all reactions I have had are due to allergies.....i don't see the consultant again until 11th March...but am convinced some of these reactions are due to the prednisolone...I know it is important to give as good a picture on CT scan as possible,, but doctors seem reluctant to even consider the fact it may be prednisolone contributing to my reactions...every day my moods seem to be stressful etc.....not my way as usually so well composed etc..what can a girl do? GP's absolutely deny it is the prednisolone..do I have to wait until mid March to get answers and be told I can stop taking them...don't want to stop taking the meds of my own volition. Allcomments will be greatly appreciated....

bloated
Regular Member


Date Joined Jun 2003
Total Posts : 418
   Posted 1/22/2014 11:13 AM (GMT -7)   
My best advice is while on pred to limit salt and caffeine. And say everything to yourself before you say it loud, lol. Good luck, I hope you feel better.
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