I have been on the 6mp for a year. I started 6 months after my diagnosis and after my firsts serious flare after fistula surgery. Did I notice a difference, yes. I am in the bathroom less, my stomach pains are not as severe and I am more consistant in the consistancy of each bowel movement, that is the biggest difference for me. Now, let me also say that I have had 3 major flares in that year and 1 minor one, thankfully when I am in flare mode, I don't have as much abdominal pain as I have read other have, but I am achy and in the bathroom constantly. Are the results what I want them to be? No, I want to be normal and that is the part I struggle with most, what is normal for me. I would say that I have noticable improvement since beginning this treatment that I did just being on Pentasa in the early stages of my diagnosis. The side affects aren't such that I would caution you away from it. I think things have been pretty managable.
I am on the fence on this - YES it definitely helped after my last flare, my only downside is that I tend to get severe sinus infections on this and it can take a few months and different drugs to get rid of it. I also tend to feel like I have a constant yeast infection from it.
I am off right now (have been since April) due to severe Sinus infection that I could not fight, and I am just now starting to notice that I am running to the bathroom a lot more, feeling tired, etc. So I am not sure if I want to go back on it or not. I am getting some bloodwork done this week to see my SED rate, etc is and that will also factor into my choice of going back on or not. I really don't have any other choices at this point - it is Immuran or Prednisone. Remicade is a no go to me due to the fact that I also have Lupus, Humira - don't know yet.
My biggest complaint would be the yeast infections when on it, but then my biggest complaint being off of it is that when I went off it abruptly my menstual cycles and hormones were wacked for MONTHS - I mean to the point of having PMDD, it has just finally gotten back to normal 7 months later, my drs theories are that it took almost 6-7 months to get completely out of my system.