mesalamine question.

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Regular Member

Date Joined Jul 2005
Total Posts : 138
   Posted 9/11/2007 6:23 PM (GMT -6)   
Hi all,
I have a mesalamine question.  On Saturday at the Guts & Glory walk I was given a Lialda brochure and am interested (I'm currently on Asacol).  My question is what are the differences between the various mesalamines? (Asacol, Pentasa, Lialda, Colazal)
I thought I understood that they released at different points in the intestines but are they the same, just different brand names? 
Thanks for your help.
p.s. the CCFA walk turn out was huge!  I think the number was at least 400 more than last year. 
24 years old
Crohn's Colitis - officially diagnosed Feb. 2005
(Asacol, Imuran, Folic Acid, Iron, B12 shots)
Interstitial Cystitis - 2002
Raynauds - 2005
(mittens & space heaters, for now) 
"I can do all things through Christ who strengthens me." Phillipians 4:13

Forum Moderator

Date Joined Nov 2003
Total Posts : 7056
   Posted 9/11/2007 6:30 PM (GMT -6)   
Acocrding to the prescribing info, Lialda is released starting in the terminal ileum. The main difference between this and the other mesalamine products is that the capsules contain much larger amounts of mesalamine and is taken once or twice a day.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?

Veteran Member

Date Joined Apr 2006
Total Posts : 1884
   Posted 9/11/2007 11:33 PM (GMT -6)   
Pentasa is released throughout the small intestine, while Asacol is released in the terminal ileum and colon. Lialda, which can be taken only once a day, seems to have been created mainly to compete with Asacol.
Daughter (19) Dx'd Crohn's 3/06. Misdiagnosed for two years, including by top pediatric Crohn's specialist as stress and needing more fiber but landed in hospital in 3/06 with cramps, vomiting, stricture. In remission with Entocort 3 mg (one pill), SCD multivitamin, homemade yogurt, vit D3 800IU, 900+ mg calcium, B complex vit, 25 mg iron. Now on modified SCD (added rice and potatoes).  

Regular Member

Date Joined Jul 2005
Total Posts : 393
   Posted 9/12/2007 1:19 AM (GMT -6)   
if this is true then why would my doc put me on Pentasa...when all of my Crohns is in the large intestines? Im he purposely pushing a certain drug

in the past I had been on asacol and colozal...never pentasa which I thought was a ulcerative colitis drug versus a crohns drug

Anyone can give up, it's the easiest thing in the world to do. But to hold it together when everyone else would understand if you fell apart, that's true strength

Diagnosed with severe Crohn's colitis in May 2005. I deal with daily arthritis ALL over my body, cystic acne, & fibromyaglia. Have taken Imuran, Remicade, TPN, Colozal, Entocort, Flagyl, PamineForte, Cipro, Dicyclomine, Prednisone, Asacol, Prevacid, and the list goes on. Taking low amounts of Pred now & 3600mg of Asacol currently...Can't wait till I can get back on Remicade, my miracle drug!

Veteran Member

Date Joined Mar 2007
Total Posts : 1019
   Posted 9/12/2007 3:47 PM (GMT -6)   

Pentasa releases throughout the small intestine AND the colon.  Lialda and Asacol release at the end of the small intestine and the colon.  So any of these are suitable for Crohn's in the colon.

As for them some of them being Ulcerative Colitis meds and not Crohn's meds, they're all used for both.  But they're considered mild drugs for Crohn's.

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