I've only ever had one bad case of cdiff and I've had CD for 19 years. If you're worried about the anti-biotics weaking the flora in your gut, why not take some probiotics? Like plain old acidophilus. That might be a way to combat a possible cdiff problem. There are some probiotic strains that specifically target those kinds of bacteria. If you google it, you'll find more info than you ever wanted. Hope that helps a little.