Prometheus test for children

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Mormor Vicky
Veteran Member


Date Joined Mar 2007
Total Posts : 684
   Posted 9/18/2007 9:13 AM (GMT -7)   
Both my daughter and I have Crohn's.  My granddaughter just turned 6.  My daughter is concerned that Skyler might have crohn's since she is so tiny, gets mouth ulcers, says her tummy hurts fairly frequently.  She talked to her pediatrician and the doctor ordered blood tests.  I'm not sure if it's the prometheus test but does that show if you have crohn's or just that you're pre-disposed to getting it in the future?  I think it checks your DNA markers. 
Vicky / 47 years old
DX'd with Crohn's during a resection August 2006
DX'd with Steriod induced Diabetes November 2006
Considered in Clinical remission but have minor signs of disease activity
 
Daughter (26) also has Crohn's since she was 12.
 
Currently on 4000mg of Pentasa only for Crohn's
No longer able to take 6-MP because of Bone-Marrow Suppression
Cymbalta, Metformin, Lipitor


beave
Veteran Member


Date Joined Mar 2007
Total Posts : 1091
   Posted 9/18/2007 12:27 PM (GMT -7)   
The Prometheus test for IBD looks at the levels of several different antibodies in your bloodstream, antibodies that are specific to Crohn's or UC.  It's not a genetic test.
 
Prometheus does have another test, this one is genetic, that tests for a person's ability to metabolize Imuran or 6-MP.  This test is called the TPMT Genotype.
 
The pediatrician probably ordered the first, or possibly just ordered tests for ESR and CRP, two tests that look for inflammation markers.

Mormor Vicky
Veteran Member


Date Joined Mar 2007
Total Posts : 684
   Posted 9/18/2007 12:46 PM (GMT -7)   
Thanks Beave, I had both tests but at the same time when I had bone marrow suppression. The doctors started to think that I had bechet's instead of crohn's but it turns out I did have Crohns and that I couldn't metabolize 6-mp. I just wish they had run the test before I started 6-mp.
Vicky / 47 years old
DX'd with Crohn's during a resection August 2006
DX'd with Steriod induced Diabetes November 2006
Considered in Clinical remission but have minor signs of disease activity
 
Daughter (26) also has Crohn's since she was 12.
 
Currently on 4000mg of Pentasa only for Crohn's
No longer able to take 6-MP because of Bone-Marrow Suppression
Cymbalta, Metformin, Lipitor


onebloodonelife
Veteran Member


Date Joined Feb 2006
Total Posts : 842
   Posted 9/18/2007 1:40 PM (GMT -7)   
Your GI didn't give you the TPMT test before prescribing 6MP? Mine refused to allow me to fill the prescription until the test came back okay.
Crohn's Disease for a year and counting
Imuran: 150mg
Humira: got 4 shots on 9/12, still technically waiting for approval from my insurance
Dicyclomine and hyoscamine for intestinal cramping and spasms
www.myspace.com/onebloodonelife
http://studentwebs.winona.edu/catraun4902 <--This link will be changing, but for now it works!


myTYTY
Regular Member


Date Joined Sep 2007
Total Posts : 22
   Posted 9/18/2007 2:11 PM (GMT -7)   
We did the prometheus test on my son and it came back negetive... a year later we did a capsul edoscope and it became clear that he has Crohn's. We are also in the testing proces for our youngest (he is six) and his prometheus test came back negetive, but in his colonoscopy it showed a possible ulcer in his terminal ilium. Biopsies have been normal the really only effective test that we have found for our boys has been the sed rate and the pill cam(capsule endescope). Our Ped.GI said that it is really hard to dx in kids and that it is just best to wait for disease progression. I doubt that this helps, but if I had to do it over again I would have just gone straight for the capsule....
Hope things work out.
Nat

Mormor Vicky
Veteran Member


Date Joined Mar 2007
Total Posts : 684
   Posted 9/21/2007 1:28 PM (GMT -7)   
Hi guys, I need your prayers. Michelle's pediatrician just called her and found something in my Granddaughter's test results. Wants Michelle to come in on Monday morning for a meeting. I'm so scared for both my daughter and granddaughter. Please say some prayers for my family.
Vicky / 47 years old
DX'd with Crohn's during a resection August 2006
DX'd with Steriod induced Diabetes November 2006
Considered in Clinical remission but have minor signs of disease activity
 
Daughter (26) also has Crohn's since she was 12.
 
Currently on 4000mg of Pentasa only for Crohn's
No longer able to take 6-MP because of Bone-Marrow Suppression
Cymbalta, Metformin, Lipitor


gachrons
Veteran Member


Date Joined Mar 2007
Total Posts : 4527
   Posted 9/21/2007 1:56 PM (GMT -7)   
Hi Hope the test don't show IBD and will be thinking of you and your family.Best Wishes try not to worry until you know for sure. lol gail
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