I know studies are inconclusive, but I was wondering if you all thought that Imuran/Methotrexate and such might actually slow down the progression of Crohn's directly. I know that drugs like the 5-ASAs, Prednisone, and Remicade just block a step in the inflammatory process so its doubtful that they have any direct effect in slowing the progression (aside from preventing inflammation and thus damage and therefore making the disease easier to treat). That makes sense to me.
But since Imuran kills off T-Cells, it seems like it might have a shot at reducing the immune systems "exposure" to whatever it is that its attacking. So at least with Imuran there is a shot... and its already been proven to slow disease progression in RA, whereas prednisone obviously does not and I'm pretty sure biologics don't slow it down either.
Just curious about what you guys thought... I'm wondering if I should just go ahead and bite the Imuran bullet, especially if this is the case.
Male Age 23. Diagnosed/Undiagnosed with IBS/Crohn's but no one really has a clue whats wrong with me. Right now I'm assuming its mild Crohn's. History of HORRIBLE Sinusitis, PND, allergies (very rare allergy to erythromiacin). Currently taking Lialda.