There have been a lot of different threads on this and IMO it all really depends on your own sensitivity and tolerance.
I have not used the syringe, but the pens are fine...sure they burn, but for a very short time....I do let the pens get to room temp and I ice the injection sites before and right after.
For me the thighs were the least painful shots and other than the immediate burn there was no after effect. When I get a shot in the stomach I am sore in the muscles for a day of two.
We all have to find what works for us and then stick with it.
dx IBS 1999 UC 2000 CD 2001
Tested BIOGEN TYSABRI (gave me 2 years of remission)
currently on Low Dose Netroxene (started Jan. 19, 2007)...against Dr's wishes, he was pushing for Remicade. Stopped the Naltrexone July 28th...started Humira Aug 31st, 2007...current dose two shots every other week.
Crohns is currently active and has been since April of 2005
51 yrs old