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rootsmith
Veteran Member


Date Joined Jan 2004
Total Posts : 598
   Posted 10/5/2007 1:21 PM (GMT -7)   
Has anyone had problems with this drug? Both the gi NP and my regular NP suggested I try it because of my foot pain.  I started at 50 mg. I had some immediate improvement but after a few doses felt like a new woman. then I thought it was making me a little quesy (sp?) so I cut back to 25 mg. Then I notice my blood pressure climbing. The last day I took it I felt great, on top of the world and my systolic bp was 165.  So I stopped taking it, within about 36 hours my bp was normal again. (on one bp med)  A little research and I found out that  ultram is a very mild inhibitor of serotonin AND norepinephrine reuptake (same principal as the antidepressants, but some like paxil just targe serotonin. Some like cymbalta target both)
 
Does anyone have this problem with these drugs that also target norepinephrine?  I feel like a freak. Half the world is on these drugs and I can't tolerate them.  Cymbalta worked great for the foot pain.  Tonight I start on 5 mg lexipro. I thought about trying ultram at 25mg and add acetominophen but now I understand that you can't take ultram and lexipro together. 
 
I was not impressed with ambien. I thought that improved sleep (had a hard time falling asleep due to foot/leg pain) would improve the chronic pain. On 10 mg I fell asleep within 15 minutes, got about 5 hours of solid sleep, almost like anesthesia. If I took it at 10 pm-ish felt great the next day. If I took it at 1 am (like after work) I felt draggy. 
 
 
Has lexipro helped anyone with chronic pain?
10 years, many tests, 3 gi doctors, Pentasa 1000mg 3x day


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 10/5/2007 6:55 PM (GMT -7)   
My daughter used to take Ultram for her Fibromyalgia pain and one day I didn't have any of my pain medicine available so she gave me one of her Ultram's. That stuff upset my stomach really badI won't take it again. I don't know if it did anything with my BP, but it sure tore up my gut. Have you seen a Rheumy yet? I think all of us should see one, most of us have inflammatory arthritis due to our Crohns. I know alot of folks on the Fibro board use the Lexipro, maybe you could swing over there and ask there thoughts. You are not a freak by the way, Ultram doesn't like me either.
Been living with Crohn's Disease for 32 years.  Currently on Asacol, Prilosec 60 mg, Estrace, Prinivil, Diltiazem, Percoset prn for pain and Calcium.  Resections in 2002 and 2005.  Recently diagnosed with Fibromyalgia and doing tests to see if I have Inflammatory Arthritis or AS.


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 10/5/2007 7:52 PM (GMT -7)   
I take 200-300 mg of tramadol [generic Ultram] per day for the pain of my neuropathy. I have had no side effects. I have a long history of hypertension but there seems to be no effect from the tramadol on my BP. Today at the rheumy's office my BP was 104/64. I'm so sorry you are having so many problems with meds. There are several classes of meds I cannot take because of my inability to metabolize them properly so I understand your frustration.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?
 


rootsmith
Veteran Member


Date Joined Jan 2004
Total Posts : 598
   Posted 10/6/2007 4:14 AM (GMT -7)   
Isn't it amazing that two people can have a problem (hypertension) and take the same drug and one person can't tolerate it for this reason and the other can. 200-300 mg sounds like a big dose. It worked pretty good for me at 50mg. The pain in my lower legs which is supposed to be due to neuropathy as a result of the tendon inflammation in my feet was gone. I still had a little burning pain in my metatarsal area of my foot but that's ok, not looking for perfection. Neuropathy has to be one of the worst experiences. It extends up my lower leg and feels like every small fiber end is vibrating. Someone once described it to me like a "small engine always running in her legs"

Nanners, yes, they use ultram (tramadol) for fibro. I thought I was feeling a little squishy the next day in the stomach which is why I cut back to 25mg. I wish I had started at that dose. Last night I took 5 mg of lexipro and so far..... so good. I made the mistake of getting on a drug forum last night and found many posts about the horrible side effects of this drug- mainly hot flashes! This is what I had on cymbalta (in addition to the hypertension problem)- started in the tip of my toes and advanced upward, felt kind of like that warm intense feeling you can get from iv contrast for a CT Scan. Awful! I went to the ER one night after work. I am tempted to say on one dose of lexipro (I'm pushing my luck here) that the hot flashes I was having, which seem to me exactly like menopausal hot flashes and not like what I had on Cymbalta, are lessened. I have not had one yet this mornng, even after drinking a cup of coffee. I'm sure I jinxed myself now :<) They didn't start till about day 3 with Cymbalta.

I've been to a rheumatologist at least 4 times with workups. The last time he was sure I had IBD (4 years ago) Cured my knee inflammatory arthritis with a steroid injection but all he could offer for other joint symptoms was NSAIDS. That is where I will be heading next if lexipro doesn't help with this problem but I don't have much hope for anything else from him. My gi office says NO NSAIDS. The podiatrist was useless, insisted it was a biomechanical problem. I'm sure that is adding to the problem, or at least it may be, but I don't believe it is the root cause. The gi office said foot pain is very common with IBD.
10 years, many tests, 3 gi doctors, Pentasa 1000mg 3x day


Sugarmarie
Veteran Member


Date Joined Jul 2003
Total Posts : 1205
   Posted 10/6/2007 7:36 AM (GMT -7)   
I took this before it made me talk non stop and then as is it starts to wear off I get the worst headache ever possible. I stop taking it the headaches were not worth it and all the talking drove DH crazy.
Confucius say : He who goes to bed with itchy butt wakes up with stinky finger.

Words of wisdom: Never trust a fart

:) Sugarmarie A.K.A. Poopy Pants :)


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 10/6/2007 4:43 PM (GMT -7)   
FYI - my total daily dose is 200-300 mg. If I took that much at one, I would be out - LOL! I have pretty severe neuropathy in my feet and legs and use the tramadol with neurotin to control the pain.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?
 


rootsmith
Veteran Member


Date Joined Jan 2004
Total Posts : 598
   Posted 10/7/2007 9:56 AM (GMT -7)   
Ok, good you clarified that. DUH and I work in pharmacy. Technician NOT pharmacist LOL Well, my excuse is I don't deal very often with the controlled drugs.

Have you been given a reason for your leg neuropathy? Or is it due to the disease in general? The reason I ask is because I had this neuropathy, or whatever, for years. One doctor said it was diabetic neuropathy. Most had no idea. One said (and he was otherwise a great doctor) "now that is something that would baffle even a neurologist" The neurologist told me I was 'reacting to normal noise" After YEARS I start to feel pain in my feet and I get sent to a podiatrist who tells me that yes, sometimes plantar fasciitis (which doesn't have to have heel pain, mine is all forefoot) presents with just leg pain. It is unusual, but possible.
10 years, many tests, 3 gi doctors, Pentasa 1000mg 3x day
diovan, simvastatin and now lexipro


Flaminguts
Veteran Member


Date Joined Dec 2004
Total Posts : 962
   Posted 10/7/2007 11:27 PM (GMT -7)   

Howdy Roots-

I just wanted to say that I take methadone for my chronic pain problems- I have crohns and spondylitis. I think that my arthiritis is the worst thing right now and the hardest to deal with. My Crohns is somewhat under control but the arthritis is still not controlled- it is flaring each time my Remicade wears low (after a month it wears off, I get doses every 6 weeks)

Methadone has been a real lifesaver- if you need something long lasting.

Anyhow- I haven;t stopped by Healingwell in many months so I just wanted to say heloo to all the people I used to talk to on a regular basis- Stay strong!


Diagnosed Jan 25th 2004, Resection Jan 25th 2005, trying to keep this disease at bay, taking Imuran, Remicade, Methadone, Phenergan, Lots of vitamins. If you want to know more about me go to my MySpace page http://www.myspace.com/131555682
"History does not long entrust the care of freedom to the weak or the timid"
 Gen. Eisenhower


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 10/8/2007 6:33 AM (GMT -7)   
Hey Deckie nice to see you again. Don't be a stranger.
Been living with Crohn's Disease for 32 years.  Currently on Asacol, Prilosec 60 mg, Estrace, Prinivil, Diltiazem, Percoset prn for pain and Calcium.  Resections in 2002 and 2005.  Recently diagnosed with Fibromyalgia and doing tests to see if I have Inflammatory Arthritis or AS.


JaSanne
Veteran Member


Date Joined Oct 2006
Total Posts : 2035
   Posted 10/8/2007 10:54 AM (GMT -7)   
Ultram made me itch intensely and gave me a rash. My husband takes it for his knee pain without incident, but I'm glad you pointed out the high blood pressure problem since my husband does have hypertension and could be having his BP raised due to this drug.

I take Neurontin for nerve pain, but it only does so much. As far as a narcotic goes, I been changed over to Talwin.
48 yr. old. Ileocolitis.  CD since early teens, misdx'd until age 36.  Hemicolectomy-left side in 2001.  Disease returned in 2003. Arthritis, episcleritis, chronic pain due to surgeries (nerve damage, adhesions) and disease.  Recently dx'd scoliosis.  History of endometriosis.


Matthew
Veteran Member


Date Joined Oct 2004
Total Posts : 3932
   Posted 10/8/2007 12:09 PM (GMT -7)   
LOL. This just goes to show you how we are all different! To me, Tramadol has similar side effects to Coedeine or Darvocet, except it works better than even hydrocodone ( my average dosage is 100 mg) . I take it for both Osteoarthritis & my CD peripheral ( or whatever the heck the rheumies call it.) arthritis. I was taking it for stone pain at first.
I've never noticed any itching or BP issues, & I have Hypertension anyway.

Matthew
To me this has been a very good pain med, with less dependancy issues than a classical opiate..
PS.
At least its not strike 3, back from pain clinic this AM. No AS in the back, just a ton of Osteo..

chrissy27
Regular Member


Date Joined Oct 2007
Total Posts : 67
   Posted 10/8/2007 4:53 PM (GMT -7)   
i was just given a Rx for ultram 50mg today for my joint pain....haven't picked it up yet but will start it tomorrow....i wonder if i should see a Rheumy....
27 yr old female, diagnosed with crohn's colitis with stricture of the colon april 2007--still new to this whole thing--
 
medications:  Imuran 50 MG, Lialda 1.2g


rootsmith
Veteran Member


Date Joined Jan 2004
Total Posts : 598
   Posted 10/8/2007 5:20 PM (GMT -7)   
I liked the way ultram worked (the short time I took it). The only reason I stopped it was because of my elevated blood pressure. If I get a chance to try it again I will start slowly, at 25mg and work up gradually. I've seen that recommended. I've read that you shouldn't take ultram and lexipro together so I won't be trying ultram again for awhile
10 years, many tests, 3 gi doctors, Pentasa 1000mg 3x day
diovan, simvastatin and now lexipro


Matthew
Veteran Member


Date Joined Oct 2004
Total Posts : 3932
   Posted 10/8/2007 6:18 PM (GMT -7)   
Are you sure it was the Ultram & not some other factor?
But we are all different so maybe so. Personally, only decongestants & stimulant containing meds raise my Blood pressure, I guess I'm lucky..

Matthew

rootsmith
Veteran Member


Date Joined Jan 2004
Total Posts : 598
   Posted 10/9/2007 9:18 AM (GMT -7)   
I don't think so. I keep fairly detailed records and you can see the before and after readings and the elevation only occurred after about 12 hours on the drug. I had no idea it targeted norepinephrine in addition to serotonin so it wasn't like I was worrying about it. I didn't expect any problems. I agree it could be another factor and that is why I am willing to try again slowly. I probably should have just cut back to 25mg while I was on it. I don't know why I didn't do that.
10 years, many tests, 3 gi doctors, Pentasa 1000mg 3x day
diovan, simvastatin and now lexipro


rootsmith
Veteran Member


Date Joined Jan 2004
Total Posts : 598
   Posted 10/9/2007 9:21 AM (GMT -7)   
Just re-read my original post and see that I DID cut back to 25 mg DUH I've been on and off so many drugs I lately I don't know what I am doing. Good thing I write things down. I will correct that to I should have stayed at 25mg for a few days!
10 years, many tests, 3 gi doctors, Pentasa 1000mg 3x day
diovan, simvastatin and now lexipro

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