humira and being tired

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Veteran Member

Date Joined Sep 2006
Total Posts : 2527
   Posted 10/6/2007 3:45 PM (GMT -6)   
I did my 2nd dose of humira yesterday and I woke up every cpl of hours last night til about 6am.  After that I slept til 10:30...I woke up for about 40 mins then went back to sleep til about noon.  I got up had something to eat and fell back to sleep for a cpl hrs til my husband woke me up to write our rent check...the landlord doesnt stop by if the 1st falls during the week he comes the following weekend.  I then fell back to sleep til about 4. 
I have to make sure I stay up now since I have to go to my parents house and take care oif the dogs...then come back home and get up early in the AM to go there again...they left this morning and will be back monday evening.  I dont recall being this tired after my initial loading dose
Dx with Crohn's 1987, symptoms as early as 1984.
Temp iliostomy February 2007, reversed June 2007, Ovarian cysts, migraines, allergies (incl food allergies) , oral allergy syndrome (diff than true food allergies), Asthma, Gall Bladder removed 1999, Inguenal hernia 1987

Regular Member

Date Joined Jun 2006
Total Posts : 267
   Posted 10/6/2007 5:37 PM (GMT -6)   
I had my loading dose of Humira a week ago and haven't had any additional fatigue from it. I have my second dose in 6 days and I sure hope that I don't go thru the same fatigue you are experiencing now. I hope that you feel more active and alert soon dear. Take care!

Marci C.
38 years old, dx with Crohn's disease March 2007, currently on Humira, Entocort and hydrocodone (for pain)

Regular Member

Date Joined Sep 2007
Total Posts : 182
   Posted 10/6/2007 6:10 PM (GMT -6)   
I really think this is normal! I have been on HUMIRA for about 8 months now and honestly, I am always exhausted (and very very fatigued). But I do think a lot of this IS because we have Crohn's. Do you know what I mean? It could be a stage of your Crohn's where you are getting Fatigue if this is NOT normal OR your body is trying to adjust and get used to the Humira. Hang in there! Drink some tea and try to eat semi healthy if you can. Get rest and try to go to sleep and wake up @ the same time everyday if you can. I tried this and it did not work but that is because I am always so exhausted. This could be very temporary for now. But listen to your body and do what it says until things get figured out with the Humira. Give it some more time! We know this is a big drug.
Good Luck and please let me know if you need anything!

Regular Member

Date Joined May 2007
Total Posts : 148
   Posted 10/6/2007 8:22 PM (GMT -6)   
I did my second dose of Humira on Thursday. By Friday afternoon I was incredibly nauseous and felt like I had been run over by a truck. By Saturday morning, the nausea had subsided but the fatigue was incredible. I have been really tired since the first loading dose, but this second one seemed to make it much worse. My GI is not sure if it is the Humira or just the Crohn's.

Veteran Member

Date Joined Jan 2004
Total Posts : 598
   Posted 10/7/2007 12:03 PM (GMT -6)   
My son used to feel this way when getting allergy shots. Not so much the nausea but feeling like he was run over by a truck for most of the day. They affect the immune system also. his allergist didn't act like he saw this happen a lot so maybe only some people react so strongly. I believe many have this with interferon also.
10 years, many tests, 3 gi doctors, Pentasa 1000mg 3x day
diovan, simvastatin and now lexipro

Regular Member

Date Joined Sep 2006
Total Posts : 146
   Posted 10/9/2007 11:00 PM (GMT -6)   
I am so sorry for your tiredness.  I feel very fatigued most of the time.  I too am on Humira but I experienced this before Humira and have experienced this overwhelming tiredness for about 3 years or more now.  I keep bringing it up to every doctor I see and all say the same is your crohns.  Some mornings I am so tired I can't get out of bed to go to work and sleep till noon.  That part sounds alot like me.  One doc even diagnosed me with Fibro but my crohns MD said it was just crohns so who knows.  I hope you feel better.  I would get blood work soon but I am sure with the Humira your MD has.  It is so frustrating.  Hang in there 

35 yo--Crohns since 2000, Granuloma cysts in mouth-oral surgery X2 in 2000, Fistula colon 2006, Rectovaginal Fistula 2007, Joint pain. Kidney Stones. Dx with Migraines in 2002 and Ovarian Cysts with Endometrosis 2001.  Dx with Fibromyalgia in 2007.  Now receiving Humira, Topamax 300mg daily, Cymbalta 120mg daily, Prevacid 30mg, Maxalt, Vicodin and Ultram as needed, Fish Oil, and Multivits   

Regular Member

Date Joined Dec 2003
Total Posts : 109
   Posted 10/10/2007 10:19 AM (GMT -6)   
Humira makes me really tired also.  I take my dose on Fridays after work.  I can feel it kick in after a few hours. I hate doing the dose on the weekend, but need those days to get my strength back.  The fatigue is the main side effect for me.  It's very frustrating when you are used to being very active.

Diagnosed w/Crohn's Disease 1988.  One resection at Terminal Illium.
4 g - Pentasa
75 mg - Azathioprine
40 mg - Humira
B12 injections monthly
various supplements

Veteran Member

Date Joined Feb 2006
Total Posts : 842
   Posted 10/10/2007 11:17 AM (GMT -6)   
Yep, Humira, and when I was on Remicade, both make me very tired afterwards. I actually have a Humira dose today, so I'm expecting to nap when I get home, and I'll go to bed earlier tonight.
Crohn's Disease for a year and counting
Imuran: 150mg
Humira:finally got approval on 9/21, done with loading doses, starting biweekly schedule on 10/10
Dicyclomine and hyoscamine for intestinal cramping and spasms <--This link will be changing, but for now it works!

New Member

Date Joined Jul 2015
Total Posts : 4
   Posted 3/1/2016 6:10 PM (GMT -6)   
I just took my first doses. I cannot stay awake. But I was always tired even before the Humira. But I could stay awake. With the Humira if I sit down, I am asleep. I was finally diagnosed with crohns, thank God. I was first diagnosed with Ulcerative colitis. Then I was told by a new Dr. After my colonoscopy that I had neither. My problems continued. I now have a new Dr. He did a colonoscopy abd a video capsule. He said everything came back crohns. So he is trying me out on Humira. Question? On your first fill-up shots who felt better. Because I do.
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