But that is always the decision facing us w/every drug for our illness, whatever that illness is. We have to weigh the risks vs our quality of life - or even w/some illnesses w/our life itself.
I thank God each and every day that my Crohn's has remained mild enough that Imuran has kept me fairly comfortable and in and out of symptomatic remission. I hope to never have to consider the options of the biologics such as Remicade, Humira, etc. despite the wonders they have done for some crohnies.
On the other hand, I am grateful that they are an option for those who need more than Imuran or 6MP can provide.
Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.