6MP versus Imuran on pancreatitis side effect

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Veteran Member

Date Joined Jan 2006
Total Posts : 3129
   Posted 10/19/2007 2:01 PM (GMT -6)   
OK so with everyones help here and some great peole at my local support group this week, I am ready to start imuran/6mp therapy.  Supposedly 6mp is less costly than imuran, but one woman told me she developed pancreatitis from 6mp and has no problems with imuran now.
These are virtually the same meds so does one have a higher risk of pancreatitis than the other?
Are there any other side effects that are more prevalent in one than the other?
GI keeps using the word Imuran, but I don't know that he has a preference until I see him in mid November.
Dx'd '90 (emergency rupture), symptoms ignored long before that, '03 fistulas and bad flagyl reactions, B12 weekly, Pentasa [until I surrender to the bigger meds]
I'm riding on the escalator of life....

Veteran Member

Date Joined Mar 2006
Total Posts : 1169
   Posted 10/19/2007 2:09 PM (GMT -6)   
HH, I think they are basically the same medication. As I understand it, imuran metabolizes into 6mp in your system. I have seen a few posts here from people who experienced some side effects from one but not from the other, but more often it is a matter of lowering doses. The two main side effects i have seen info on are leukopenia (suppressiion of white count) and pancreatitis, the first being mroe common than the second, but in only a small percentage of patients. I think the white count problems show up in 10% or so. I have been on 6mp for 5 years now with no problems and good results. The dosage used for Crohn's -- usually 50-75 mg -- is far less than what the drug is used for in other conditions (leukemia for one.) And, there have been several long term studies showing no appreciable cancer increases in 6mp patients. The only thing shown is a very very slight increase in the incidence of lymphoma, but that can also be higher in Crohn's patients in general from long term inflammatory damage.
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