Imuran Humira or Remicade

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New Member

Date Joined Nov 2007
Total Posts : 3
   Posted 11/20/2007 10:05 PM (GMT -6)   
My Crohn's is getting worse and my doctor wants me to choose from Imuran, Humira or Remicade what's anybody's opinon?

Veteran Member

Date Joined Apr 2007
Total Posts : 531
   Posted 11/20/2007 10:18 PM (GMT -6)   
Humira for convenience and has less reaction rate. It is also cheaper with my insurance than remicade. I have never taken imuran, but I do know you need constant monitoring of labs. Good luck to you.
Diagnosed at age 19 with CD.
3 small bowel resections, 1 for perforation, 2 for strictures 

ski bum
Regular Member

Date Joined Jan 2007
Total Posts : 451
   Posted 11/20/2007 10:31 PM (GMT -6)   
When I was faced with those same options, I chose Imuran. My feeling was that Remicade and/or Humira would be my last step before opting for surgery (unless something else comes along). I think of these as the heavy guns for this disease. Imuran has been used longer than the biologicals and therefore, long term effects are more known than with the biologicals. Imuran is taken orally rather than by IV or injection - easier to manage. Initially, labs are drawn something like every two weeks on Imuran, and then eventually, it's every 6 weeks. I think that's easier than sitting for 4 hours to get an infusion or dealing with the Humira injections. The downside with Imuran, at least for me, was that I never really felt that well for the 11 months I tried it. I'm giving Humira a try now. Good luck with your decision.
CD dx'd Aug 05. Initially on Pentasa, then Imuran 125 mg. Started Humira (very reluctantly) on 10/24/07. Currently on Humira, Imuran and Entorcort. Hope to dc Imuran and Entorcort within one month of starting Humira.

Regular Member

Date Joined Jan 2006
Total Posts : 355
   Posted 11/20/2007 11:09 PM (GMT -6)   
I've taken them all and Humira was the miracle drug for me. The shots are really not a big deal. They sound worse than they actually are. Good luck.

Regular Member

Date Joined Nov 2007
Total Posts : 41
   Posted 11/21/2007 12:03 AM (GMT -6)   
I havent ever used Imuran, or Remicade but im currently using the humira. My dr. gave me the same option minus the imuran. i think the big thing for me was that once you start the remicade you are either on it forever or when you stop you cant ever take it again since you build up the antibodies ( atleast from what i understood) and with the humira you can take it and stop and start again if needed.
Good Luck

Regular Member

Date Joined May 2007
Total Posts : 148
   Posted 11/21/2007 7:22 PM (GMT -6)   
I've tried them all. The Imuran worked well the first time but the second time made me so nauseous I could not continue. Remicade worked really well but I developed lupus-like syndrome. I am now on Humira, which seems to be working with few side effects after 8 weeks. You might want to start with the Imuran for all the reasons ski bum suggested, although it takes a while to start working. If it does not kick in, you can always switch over to the Humira or Remicade.

Regular Member

Date Joined Nov 2007
Total Posts : 165
   Posted 11/27/2007 11:57 AM (GMT -6)   
I tried several combinations of drugs before finding that Remicade is the only one that works for me. It is a hassel to have to go the hospital for 3 1/2 hours every 8 weeks after the loading doses, but SOOO WORTH IT for me!! I feel 1000% better than before. Once you stop taking Remicade, there is a chance you will have a reaction if you start taking it again, but they give you a steriod to try to prevent it. I started then stopped (had a blockage and needed my first resection surgery) and have restarted with no reaction and once again am feeling WONDERFUL these days! Remicade is very expensive and some insurances give you issues with paying for it. I am very insurance (which is free to my husband thru work) pays for all of it with no questions. Every person is different so you have to choose what's right for you in your heart after weighing all options. Good luck!

Fibromyalgia DX March 2003
Crohn's DX Jan 2006 (Symptoms since 96-Misdiagnosed as "female" problems-Major flare during pregnancy in 05 which lead to DX)
1st resection July 2007
Currently on Remicade/8 weeks

Regular Member

Date Joined Aug 2006
Total Posts : 331
   Posted 11/27/2007 3:40 PM (GMT -6)   
I am on Imuran & Humira, I am allergic to remicade.  God Bless

Dx with CD 1987, 3 resections, 3 abcess sx, OA back & hips, bulging disk, Major depression/anxiety, kidney stones & sx to remove, now 44 yrs old.  Still trying to figure this disease out & of course all the little extra complications that come with this rollarcoaster of a life with CD. 
Meds:Humira 40mg every other wk, Imuran .75 daily, welchol 625 x 3 daily, cymbalta 60 mg daily, norco 10/325 x 4x, fish oil, vit e,folic acid,Vit B12,inject monthly,

Regular Member

Date Joined Nov 2007
Total Posts : 114
   Posted 11/29/2007 2:54 AM (GMT -6)   
I was on 200mg Imuran and that worked for a while, but I was also on Remicade at the same time. My doc took my off Imuran and onto Methotrexate to help the joint pain. I have been on Remicade for almost 4 years now and it has been great. However now I am needing it every 4-6 weeks and have little to no relief from it. Looking into Humira now...and surgery. If I were you I would do Remicade because it works faster than Imuran, and if it doesnt work or if you are allergic to the mouse protein you can always use Humira. Good Luck!
Diagnosed: 2003, age 18 (had issues with it since I was 12)
Meds for crohns: 20mg Prednisone, 9mg Entocort, 400mg Remicade, 50mg 6-MP, 40mg Prilosec, 1mg Folic Acid, 5/325 Percocet.
Other medical issues: Hereditary Spherocytosis (hemolytic anemia) iron deficient anemia, polyarthralgia, ovarian cysts, Migraines
Surgeries: Spleen and gallbladder out at age 6, Tonsils and Adenoids out at age 21. Looking at resection surgery this year.

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