Side Effects from Remicade?

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LauraO
New Member


Date Joined Dec 2007
Total Posts : 1
   Posted 12/1/2007 5:21 AM (GMT -7)   
Hi Everyone,
 
I am new to this site.  I have had Crohn's disease for over 15 years and have been through most of the treatments available.  For many years, predinisone was the only drug that put the disease in remission, however that stopped working about 2 years ago.  My doctor changed me to Remicade infusions.  They have kept the Crohn's in check but I am experiencing so terrible issues and wanted to see if anyone else had the same experiences while on Remicade:  Severe fatigue, joint pain, muscle pain, terrible sinus (ear, nose, throat) infections, urinary tract infections, cuts in the nose and mouth, terrible hair loss, depression.  My Rhuematologist tested for Lupus and it came up positive in the blood test, but believes it may be the Remicade causing this.  She wants me to change to Humira.  I have no problem with this, but thought they were basically from the same family of drugs and would cause the same side effects.  Any feedback would be appreciated - Besides all the pain, I am loosing soo much hair.  Thanks.  Laura  

bkoach2
Regular Member


Date Joined Nov 2007
Total Posts : 24
   Posted 12/1/2007 8:58 AM (GMT -7)   
LauraO said...
Hi Everyone,
 
I am new to this site.  I have had Crohn's disease for over 15 years and have been through most of the treatments available.  For many years, predinisone was the only drug that put the disease in remission, however that stopped working about 2 years ago.  My doctor changed me to Remicade infusions.  They have kept the Crohn's in check but I am experiencing so terrible issues and wanted to see if anyone else had the same experiences while on Remicade:  Severe fatigue, joint pain, muscle pain, terrible sinus (ear, nose, throat) infections, urinary tract infections, cuts in the nose and mouth, terrible hair loss, depression.  My Rhuematologist tested for Lupus and it came up positive in the blood test, but believes it may be the Remicade causing this.  She wants me to change to Humira.  I have no problem with this, but thought they were basically from the same family of drugs and would cause the same side effects.  Any feedback would be appreciated - Besides all the pain, I am loosing soo much hair.  Thanks.  Laura  
I often have muscle and joint pain, but my docs and research suggest these may also be from the Crohn's itself (or related immune system issues).  Also, since you have recently stopped the pred., you may also be in rebound, i.e., your system is reacting to the lack of the steroid. None of the above says you are wrong in suspecting the Remicade as the main causes of some of your problems.

Male, in early 60's; diagnosed age 39 with Crohn's although I had intermittent symptoms in
childhood.  Had bowl resection 1989.  Treated with Prednisone and Asulfadine or Asacol, then started Remicade infusions every 8 weeks in 1999.  Clean colonoscopies for most part since then.  Currently, lung infiltrates seen in CT scans (no breathing symptoms) are being evaluated to rule-out possibility they were precipitated by Remicade (off Remicade at present, Crohn's worse).  On Entocort and Asacol with Tylenol w/Codene and steriod suppositories as needed.


Skjura
Regular Member


Date Joined Jun 2007
Total Posts : 210
   Posted 12/1/2007 3:11 PM (GMT -7)   
Some say that once you start the remicade you are either on it forever or when you stop you cant ever take it again since you build up the antibodies, with humira you can take it and stop and start again if needed.


Good Luck

From Skj.
 
Diagnosed CD June 2007. Have only used prednisone. Did make a difference while max dosed. Got my problems back when tapering.
 
Using Low Dose Naltrexone from sept. 2007. See yahoo.com.
LDN helps me. I am now in remission.


Aimee =)
Veteran Member


Date Joined Jun 2004
Total Posts : 1020
   Posted 12/1/2007 3:27 PM (GMT -7)   
humira does not have the same side effects as it is a human protein instead of mouse. You can take it at home alone if you need to, as the risk of a reaction is very low.

I didn't have any side effects from Remicade except hair loss until I built antibodies to it and started to react. I do know some people here have, though, so you should get some answers.

Been on Humira since last spring without any issues. It's been great!

JudyK89
Veteran Member


Date Joined Dec 2006
Total Posts : 1986
   Posted 12/1/2007 4:21 PM (GMT -7)   
Some of the symptoms you mention could be caused by antibody build up and/or a hypersensitivity to the drug, some call it serum sickness.

Remicade is known for Lupus-like reactions, and while Humira has less reactions (so far, it's still new for CD) it also can have the same reaction, it has the same black box warnings.

A simple blood test will show if you're building antibodies, and if you are, depending on the numbers, you may need to take pre-meds or discontinue taking Remicade. The test results will come with guidelines. The test is called the Prometheus Infliximab HACA.


Judy
Crohn's Disease   
 
 
 


teddybearweiser
Veteran Member


Date Joined Oct 2004
Total Posts : 3042
   Posted 12/2/2007 5:23 AM (GMT -7)   
Hi I agree with Judy, You need to have the Promentheus test done. I have been on Remicade for over 2 years and I have no-side effects.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital
in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.
 My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
My Internest doctor has me on Lisnopril-HTCZ and Folic Acid. Diagnosed
with Osteoarthritis July 2007
 

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