prednisone resistance, and emotional side effects of prednsione

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Regular Member

Date Joined Oct 2007
Total Posts : 241
   Posted 12/8/2007 10:16 AM (GMT -6)   
i cannot seem to overcome the depression and anxiety that the prednisone is causing. in addition, the prednisone doesn't seem to be working- i have been one giant flare for months. i am seeing a counselor and am on an antidepressant, but feel scared and hopeless a lot of the time. i have had 3 remicade infusions, and at first it seemed to be working, but i got c diff and had to go back up to 30 mg pred a day. i really never seem to have a respite from pain, low grade fever and arthritis, even on the prednisone, and it is wrecking my emotional health. i am thinking that i may wean off of it- it is better to be in pain and stable than in pain and unstable.
if anyone has word of advice, please help.

Regular Member

Date Joined Sep 2007
Total Posts : 39
   Posted 12/8/2007 10:24 AM (GMT -6)   
Sorry about your difficulties and wish I had some advice, but all I can offer is emotional support. I know how the prednisone can affect one's mood. I hated it but was glad that it worked for me. I hope your doctors can figure out how to make you feel better.
47 years old
Dx 3/07 Moderate Crohn's in terminal ileum-Probably had it for years earlier
Rx Prednisone initially for 8 weeks-40mg/day then tapered down to 0
    Currently on Pentasa-2000mg/day

Regular Member

Date Joined Oct 2007
Total Posts : 390
   Posted 12/8/2007 10:56 AM (GMT -6)   
Are you on 30 mg per day?  Are you taking 15 in the morning and 15 at night?  If you help to space them out at even intervals to keep the medicine more constant in your system that may help, prednisone is just terrible with the emotional side effects. :(  Good luck!

Regular Member

Date Joined Oct 2007
Total Posts : 241
   Posted 12/8/2007 12:41 PM (GMT -6)   


i am on 30, but if i take it later in the day i cannot sleep

Veteran Member

Date Joined Mar 2007
Total Posts : 4527
   Posted 12/8/2007 8:07 PM (GMT -6)   
Hi I take my pred. in the am with breakfast the drugist told me to get it out of the way I think I slept better because I took it early . The only other thing I can think of is low roughage diet .I think you should stay on the pred. till you have something else from your Dr. to help you or at least talk to him about it .I know that the pred does seem to cause some problems with thinking it is common but I find this site really helps encourage and motivate me. Are you still on the Remicade? I had to go off it and now just 20 mg of pred. I feel I have put too much weight on but getting by for now . Hope the councelling is doing some good for you. Hang in there better days ahead .lol gail

Regular Member

Date Joined Jun 2006
Total Posts : 267
   Posted 12/9/2007 10:33 AM (GMT -6)   
Survivor 49, I am so sorry to hear about the nasty emotional side effects caused by the Prednisone you're taking. I have never taken Prednisone for my CD, Entocort has been my staple. Entocort does cause me emotional ups and downs but not as severe as you're having on the Pred...and to hear that it's not working for your pain is even worse. Please talk to your GI right away, be honest with your doc and let him/her know what you're going thru, there are other medications you can take that won't cause such severe emotional upheaval. Please hang in there and know that you are not alone. Take care.
Marci, 38 years old, Rockledge, FL
Dx with Crohn's disease March 2006, currently on bi-weekly Humira, daily 6mg Entocort, daily 2-3x 5mg hydrocodone (for pain), and daily 75mg Effexor, plus 3x per day heavy iron supplements for anemia

Regular Member

Date Joined Oct 2007
Total Posts : 241
   Posted 12/9/2007 7:31 PM (GMT -6)   
thanks, marci. it helps
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