Imuran necessary before Humira - and/or during?

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Regular Member

Date Joined Aug 2007
Total Posts : 89
   Posted 12/12/2007 11:23 AM (GMT -6)   
I've been talking with my nurse practitioner. She really wants me to be on Humira, although my symptoms are currently not too bad. Everything else I've tried (entocort, pred, asacol)-I had reactions to them. She wants to start me on Imuran for probably six months, then move to Humira. I know I've read different things on here. Is it true that I should be on the Imuran first to suppress my immune system and have less likelihood of my body developing a resistance to the Humira? Do I need to stay on the Imuran all the while I'm on the Humira? She made it sound like I should only be on Imuran for no longer than six months. I know I've seen people on here that are on Imuran forever and a day and also people on Humira with no Imuran. She also said insurance likely won't approve Humira unless the Imuran is tried first.
Dx'd CD in August 2007 - 42-yr-old wife and mom
Bad reactions to Entocort, Prednisone and Asacol / Not sure what's next
Currently on Aciphex, probiotic, calcium and multi-vit; and Flovent (for asthma)

Veteran Member

Date Joined Dec 2006
Total Posts : 1986
   Posted 12/12/2007 11:32 AM (GMT -6)   
Why don't you try the Imuran for six months, and maybe it will work on its own? Personally, I know lots of people on here have been on the biologics without being on an immunosuppressant, but with your history of reactions, I would stay on the immunosuppressant if I had to go on them. My troubles all started when I was taken off the immunosuppressant while on Remicade.
Crohn's Disease   

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