Hi Eli, I'm not sure if you are the one I answered before about Remeron but I have been taking it for at least 6 yrs. I tried many other a/d meds that just didn't work but the remeron was the charm. I started slow with 15 mg,then 30 then 45. My dr. has now tapered me down to 30 mg but to tell the truth I didn't notice the difference from the 45 mg. Except, my appetite decreased. The only other side effect I had at first was feeling sleepy when I took it so take it at bedtime. Eventually the drowsiness disappeared and you wouldn't know I was taking anything. It was a life saver for my depression. So if my experience is typical you should do very well on it. Just have your dr. start you out slowly and gradually work up to the theraputic dose which would 45 mg. I wish you luck with it and do post and let me know how things are going.