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Hi Nate, First of all I am glad you have found us on HW. There are many caring members as you will see. My first question is what time of day do you take the wellbutrin? If it is causing you insomnia take it in the early morning. And check with your dr. about the valerian, but I think your pharmacist is right that you shouldn't mix supplements with your a/d meds. I know my dr. has warned me against taking anything other than what she prescribes. And be sure you get all of your prescriptions from the same pharmacy so there is a record of everything. I too have high blood pressure, although mine is very much in control due to taking a blood pressure pill. There are many out there that will not cause side effects and blood pressure is very important to keep under control. I take a bp med called Avalide. It does have a bit of a diuretic in it but that doesn't bother me. My other suggestion would be to get a portable blood pressure monitor and keep track of your bp every day. My dr. has me do this and I see her every four to six months to have my bp checked and she checks my monitor against her professional one to be sure they are in agreement. The best bp monitors are the ones where you put a cuff on your upper arm. The ones that take your bp from the wrist are not as accurate. I see other drs too, oncologist and pulmonologist who always take my bp so I am monitored frequently as well as taking my own. I also take ativan(brand name for lorazepam). I find it good for anxiety because it doesn't make me feel all dopey and tired. One other thing don't have anything to drink with caffeine in the late afternoon or evening. That will for sure keep you up. I hope I have been of some help to you and have answered some of your questions. Please keep posting so we know how you are doing. I will always be glad to answer your posts.