Has anyone tried an MAOI?

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hboy
New Member


Date Joined Sep 2009
Total Posts : 14
   Posted 9/10/2009 6:44 AM (GMT -7)   
Hi I'm new to this forum. I'm not sure if anyone can help me but her goes. I have been off work since Jan 2008 due to severe depression. Have tried many Meds-I was on Paxil for 15 years and it pooped out-I was going through a lot of stress at time. I have tried Effexor,Celexa, Lexapro, Lexapro+ wellbutrin, clomiprimine, imiprimine, cymbalta, cymbalta+ lithium, combo Paxil+ wellbrurtin+desprimine, eleven sessions of ECT with little improvement, now Moclobimide( Manerix)-its an MAOI-same family as Nardil, Parnate etc but has less food restrictions. Manerix I don't beleive avail in US. Dr put me on 600mg max dose and went on vacation. First five days were hell-anxiety, breathing diff, hostility, nervousness, chest pain, Went to my psy's backup- reduced dosage to 150mg for a week. Starting dose is really 300mg. I was on 150 mg for 10 days. Still have some side effects, including a bit of chest pain. Doc told me med doesn't really work well until you reach 600mg and we all now that we req at least 4-6 weeks to see if its going to work. Oh-Before my doc went on vacation- he sd we may have to go to 900mg!!. I think he prescribed me 600mg initally because he wants me to get better fast because I have had a hell of a ride since Jan of last year. I just increased dosage to 300mg Monday- I'm trying to get through the increased side effects, even with the chest pain-back up dr dose not think I have a heart prob- that its is prob the existing anxiety or anxiety induced from the drug. He sd he doesn't really know. Well if I didn't have chest pains and incraesed anxiety before starting the drug, would you not think its prob drug induced??
My wife is having a very hard time accepting my depression and being off work for so long- but she doesn't want to go for couples therapy. Does not think they will help us. I have tried to get her to support me, it has been a struggle. I know the stress is effecting my recovery and it is making her mildy depressed also as she has a stressful job also.
 
Has anyone tried moclobimide(manerix) or an MAOI, and have they experienced serious side effects during inital weeks of treatment? I'm having a difficult time, a have sucidal thoughts and anxiety. Having difficulty just being in same home as my wife and she with me, and having difficulty finding things to do that will help during the day, given that I have to go to another community-because my wife is concerned about it getting back to our community. Anyone? I needed to get this off my chest. Ty

MichaelD93
New Member


Date Joined Sep 2009
Total Posts : 12
   Posted 9/10/2009 6:55 AM (GMT -7)   
Well, for me those are some big words. im on a 25 mg long lasting pill. im not sure what it is. Im 16. i had a severe case of depression and some suicidal actions. but now im better. one of the things that helped me is talking with family, and close friends. you should talk to your wife about it and see what she thinks. and make a plan that works for you guys. depression is also in your mind which reflects to your physical actions.

im sorry that im not much of any help. but your in the right place. we are all here to help.

stkitt
Forum Moderator


Date Joined Apr 2007
Total Posts : 32602
   Posted 9/10/2009 7:00 AM (GMT -7)   
Hello and welcome to HealingWell. That is a whole lot of med that you have tried.

MAOI is an acronym for Monoamine Oxidase Inhibitor.

Monoamine oxidase inhibitors are a class of antidepressants used for the treatment of depression. Due to the potential for serious dietary and drug interactions they are prescribed less frequently than other classes of antidepressant medications, such as Selective Serotonin Reuptake Inhibitors (SSRIs) or tricyclics. However, in some cases where individuals prove unresponsive to other treatments, MAOIs have been tried with marked success. They can be especially effective in treating atypical depression.

The only advice re meds I can give you is to keep working with your physician as he is the one that knows the medications best.

I do not remember if you mentioned that you are in therapy or perhaps you did and I missed it. Therapy feels to me like a good suggestion for you.

Take care,

Kitt

getting by
Forum Moderator


Date Joined Sep 2007
Total Posts : 40573
   Posted 9/10/2009 11:46 AM (GMT -7)   
Hi Ty,

I think that even if your wife doesn't want to go to couples therapy that you should still go to therapy. Though I wish that she would go too. It sounds like you both need a good sounding board.

But don't give up. Keep trying, and make sure to let your doctor know everything in how the medication is effecting you. I would imagine that after a couple of weeks the feelings of anxiety and such should go away. If they don't, continue to talk to your doctor and let him/her know the problems. I really hope that this medication works for you.

Hugs, Karen
  Moderator-Depression and fibromyalgia
 
fibromyalgia, Chronic fatigue, depression,allergies


hboy
New Member


Date Joined Sep 2009
Total Posts : 14
   Posted 9/11/2009 8:33 AM (GMT -7)   
Thanks to those that replied so far and I hope others can offer their assistanace.
Getting by, I pray to GOD that these feelings of anxiety insominia, depression go away soon. Especially the chest pain. I have tried many meds and I'm afraid I'm running out of options. What confuses me is how do I know if this chest pain, anxiety is med induced or if its underlining depression. I asked my back up Psych, because my pysh was on vacation til Monday, I have appt on Tues. and he sd he wasn't sure???
 
I'm seeing a therapist-I have had 7 sessions with him and he is still taking my history and just writing notes. When is he starting to help me? He sd he couldn't help me if my wife doesn't come on board and accept whats happening to me and actively come to therapy with me. I agree but my wife won't come-she doesn't beleive it will help. I am really scared about my future.
 
Anybody else try a Monoamine Oxidase Inhibitor? Any Experiences? Do the side effects go away?
Ty

THE HAPPY TURTLE
Elite Member


Date Joined Mar 2009
Total Posts : 18747
   Posted 9/12/2009 9:08 AM (GMT -7)   
yeah tried maoi's too. did not work for me. i too have been on just about everything. keep well and know that we care. with loving compassion. jamie
 
dx, mdd, severe borderline personality disorder.

getting by
Forum Moderator


Date Joined Sep 2007
Total Posts : 40573
   Posted 9/12/2009 5:58 PM (GMT -7)   
Would your wife go to the sessions if you told her it was for your benefit? Just thought that I would ask.

I am glad that you are going to therapy. If this therapist isn't working, could you try some one on one with another?

Best wishes,

Hugs, Karen
  Moderator-Depression and fibromyalgia
 
fibromyalgia, Chronic fatigue, depression,allergies


hboy
New Member


Date Joined Sep 2009
Total Posts : 14
   Posted 9/13/2009 6:54 PM (GMT -7)   
Getting by, I did tell her that my therapist and everyone I know thinks I would benefit if she went to therapy together. She still thinks It would be a waste of time and that therapists would not help us until I felt better. If I went alone-I would have to learn how to deal with all my issues on my own. Am I just supposed to accept this. Will that be enough to heal myself?

hboy
New Member


Date Joined Sep 2009
Total Posts : 14
   Posted 9/14/2009 11:21 AM (GMT -7)   
Jamiee, thanks for your reply. If you tried MAOI and they didn't work for you. Can I ask what did or if any think is helping you now? Hboy

THE HAPPY TURTLE
Elite Member


Date Joined Mar 2009
Total Posts : 18747
   Posted 9/15/2009 3:29 AM (GMT -7)   
in short, the answer is me. in short the answer is you. self-actualization is a process, small steps, a little bigger steps, goals, then bigger. personal development, talking, learning and staying abreast of things has certainly helped also. understanding me, and accepting me has been critical as well. your defintions of what you need, and working on these will be a fruitful experience for your mind and overall health.
 
jamie. idea

hboy
New Member


Date Joined Sep 2009
Total Posts : 14
   Posted 9/17/2009 1:10 PM (GMT -7)   
MichealD93- I'm glad you are feeling better and living life again. You sd you were taking 25mg of something. Can I ask what drug you are using? Hboy

slinkyhypo
New Member


Date Joined Sep 2009
Total Posts : 7
   Posted 9/23/2009 4:09 PM (GMT -7)   
Hi hboy
 
I was on moclobemide (Auroix in Aust) for about 2 years and didn't suffer any side effects.  I was changed to Citalopram (Ciprimil) because the moclobemide stopped working successfully.  I had a very severe reaction to Citalopram and have since found out this is a syndrom called Akathisia. (I was only on citaloparm for about 5 days and couldn't cope at all - I was climbing the walls and jumping out of my skin) 
 
My gp then changed me to Zoloft.  After my reaction to Citalopram I was very concerned about changing to another medication but what else could I do.  My gp gave me a script for a calmative drug and suggested I only fill it if I felt is was really necessary.  I have been taking Zoloft now for 4 or 5 years and haven't had any significant issues.
 
I am currently exploring natural complimentary treatments and reading a very informative book Help for Depression and Anxiety by Dr Sandra Cabot.
 
hope this helps tongue
 
just a thought on therapy.  Sometimes it's good to go for some sessions alone as you can speak your mind without risking offence to your partner.  I visited a psychologist and found the sessions very beneficial.

getting by
Forum Moderator


Date Joined Sep 2007
Total Posts : 40573
   Posted 9/23/2009 4:23 PM (GMT -7)   
hboy,

I do think going on your own and facing this on your own will help YOU. That is what you need to do. If she doesn't go, so be it. You have to think of yourself and get better for you. That is what is important.

I know that it is not easy. And not always fun. But eventually you will get better and you will feel very good about it. I know that you can do this. Just keep going.

Hugs, Karen
  Moderator-Depression and fibromyalgia
 
fibromyalgia, Chronic fatigue, depression,allergies


hboy
New Member


Date Joined Sep 2009
Total Posts : 14
   Posted 9/24/2009 11:33 AM (GMT -7)   
thanks slinkyhypo and getting by for your support. Slinkyhypo did you find moclobmide to be very stimulating-its giving me insomina and a bit of chest pain and anxiety, I found that I'm agitated and my wife says I look ticked off in the face. My Pysh has not called me back like he sd he would to address these concerns. I'm concerned he might take my off and he hinted that he may try a three pill combo again. I prefer not to do that. Its that just going to give me side effects and possible interactions. hboy

getting by
Forum Moderator


Date Joined Sep 2007
Total Posts : 40573
   Posted 9/24/2009 12:10 PM (GMT -7)   
I take a three pill combo and it works good. I take effexor, xanax and abilify. They work good together. I am now adding pristiq to the mix. I am going to go off effexor being that pristiq is the same as effexor but longer acting and containing more norepinephrine (sp) in it, I guess. I will only have to take one pill a day instead of five. As I do with the effexor.

I hope that switch isn't a mistake. It is that I take so many meds and effexor is going generic in June of 2010. I am afraid that the generic wont work as good. Talk about worrying. Just looking ahead I guess.

Hugs, Karen
  Moderator-Depression and fibromyalgia
 
fibromyalgia, Chronic fatigue, depression,allergies


slinkyhypo
New Member


Date Joined Sep 2009
Total Posts : 7
   Posted 9/24/2009 6:52 PM (GMT -7)   
hi hboy
 
I didn't really have any problems on moclobmide, it just seems that medication stopped working effectively on my depression and this is why my gp changed it.   I have noticed that Zoloft tends to hype me up a bit and when I initially started taking it I had interrupted sleep patterns but after about 6 weeks that settled down or though, I still do wake up sometimes early mornings.  On Citalopram I was sooo hyped up 24/7(Akathsia) I didn't know what to do with myself, this is the only time I actually contemplated ending my life and I was only on it for 5 days.  My BIL committed suicide in 2001 after suffering depression for many years.  I knew what this did to his family and kids and I had 2 teenage kids myself to think about .  Is this what stopped me, initially, I'm sure it was.  I don't know how I would have coped if this medication had been continued.  How many times do we hear of people actually committing suicide when they are on a change of meds?  I do feel that people need to be more closely monitored when medications are being changed or adjusted.  When you are given medications that make you feel that bad, you're crap scared to change to a new one just incase you have the same situation.  I am actually going to explore using some complimentary suppliments in conjunction with my Zoloft, like taking a magnesium supplement from a natural therapy professional.
 
It is really difficult sometimes to describe a reaction or feeling.  Hyped up makes me think of some little child being over active and running around, all over the place like a crazy thing.  I think my feeling was more of inner restlessness.  I spoke to my husband about this feeling and he said at times he's noticed me moving my legs lots or shaking my foot while sitting or laying on the lounge in the evenings.
 
I once listened to a radio talkback about a doc who had surgery for brain tumour.  After hospital and having sleep patterns interruped  he suffered with depression but didn't admit to it, he thought he could cope for himself because his depression was only due to his interruped sleep and not the fact he'd had a life threatening episode. He was a doctor after all.   After a period of time he accepted a diagnosis and was put on meds and a discussion ensued about antidepressants.  A comment he made that I found very interesting was "I've heard that high flyers, stockbrokers in New York were getting prescribed Zoloft because taking it gave them a buzz or a high".
 
Maybe you should make another appointment for the doc rather than waiting for him to phone you.  You seem to be making yourself anxious waiting for him to call and worrying about him changing your meds. 
 
In the meantime, try to take care of yourself.  tongue
 
 
 
 
 
 
 
 
 
 

slinkyhypo
New Member


Date Joined Sep 2009
Total Posts : 7
   Posted 9/24/2009 7:00 PM (GMT -7)   
Hi Karen

I have been concerned about taking generics in the past but so long as the active ingredients are the same my pharmacist said there's no problems. Here is an excerpt from Wikipedia that gives a good explanation of generic drugs but I think going to the US Food and Drug Administration would probably give you more confidence.

A generic drug (generic drugs, short: generics) is a drug which is produced and distributed without patent protection. The generic drug may still have a patent on the formulation but not on the active ingredient.
A generic must contain the same active ingredients as the original formulation. According to the U.S. Food and Drug Administration (FDA), generic drugs are identical or within an acceptable bioequivalent range to the brand name counterpart.

getting by
Forum Moderator


Date Joined Sep 2007
Total Posts : 40573
   Posted 9/24/2009 7:13 PM (GMT -7)   
I know that, but that range is what scares me, I have taken generic drugs, I do now. But effexor is a scarey drug, especially when you don't have it. I know when it goes generic, I wont be able to affort the brand name. And I have taken other meds like Soma (a muscle relaxer) and I know that the generic didn't work where the brand name did. I even mentioned it to the doctor and they admitted that the generic doesn't always work the same. Of course they may have just said that to shut me up. lol...

I am going to try the pristiq, see how it works, if it doesn't work as good as the effexor I will go back. They are so close, that I think I will adjust well. I hope so.

Thanks for the information.

Hugs, Karen
  Moderator-Depression and fibromyalgia
 
fibromyalgia, Chronic fatigue, depression,allergies

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