I have been following all the AD meds and their side effects expecially weight gain. I have found in my reading that Pristiq like any medication is good for some and not for others.
I surely think it is worth a try if you are wanting to get away from taking so many pills at once and I know the cost is a bit less then Effexor .
I failed really bad trying the Wellbutrin. The first week went fine but as soon as the dose was increased it was all down hill so I am back to just Trazodone at HS again with Buspar for the anxiety.
I wish you luck and hope Pristiq is a good drug for you.