I have been on Remeron for about 7 yrs. I started out at 15mgs which made me very sleepy. You have to take it at night. I went up to 30 then 45 mgs the highest dose. My Pdoc eventually had me go down to 30 and then 15. Didn't notice any difference but events in my life caused my depression to worsen and she put me back up to 30 mgs. I have been on it so long it no longer makes me sleepy and the 30 mgs are controling my depression pretty well. I did gain weight on the 45 mgs but have lost it. It's true that the higher the dose the less sleepy it makes you but as I said take it at night. I tried at least 6 other ad meds before this one and this is the one that worked the best with the least side effects.