Your husband might have a small period adjusting from one med to the next. But give the effexor a good four to six weeks to reach its full effects. It is a good medication for some, I took it for many years. I just now went off of it and on to pristiq. The reason I switched is because I can take much less of the pristiq than I had to of the effexor.
I think that your husband will be just fine, try to be patient through this transition period. But if he doesn't get better in a few weeks, have him talk to his pdoc about going back on zoloft.
Best wishes to you
Moderator-Depression and fibromyalgia
fibromyalgia, Chronic fatigue, depression,allergies