Yep, I'm on Effexor. In my experience it works amazingly well, but there are some side effects (tiredness, strange dreams, etc.). My doctor says the side effects will go away, but I haven't been on it long enough to find out if that's true. I can tell you that it helps with the depression amazingly. The old thoughts just stop coming. It's really a decision of what's worse: the problem, or the side effects. For me it's the problem, but you know how these things are--it's different for everyone.