I don't know about Depakote or any drug, except the one prescribed for my daughter.
However, I've noticed that no one mentions getting the manufacturer's literature. There's a page pharmacies give out, but there is also a fine print page that the mgf attaches to containers. It's tough reading, but I always ask for it, because it gives you a fairly good break down of incidence of side effects and other good info.
Next I type into google the drug name and MSDS--that's the sheet the mfg has to have available for employees where the drug is made. Lots of interesting things in it--that don't make any other literature.
By now I have a good idea of all the bad things that can happen, so it's pretty scary. Then I search google using the the drug name with the word forum. What I find is lots of odd things, like with cymbalta--someone on another thread said that quitting smoking was equivalent of changing her dosage and she had an unexpected reaction. I had seen info that smoking and some over the counter meds made cymbalta less effective. I probably wouldn't have made the connection--until my body and mind reacted, but the information would have been in my head.
As I said, I don't know much of anything about drugs. My daughter doesn't either and she was in no shape to do the research--if she even would. My research kept my daughter from panic, when she experienced an uncommon side effect that wasn't listed on the pharmacy print out.
If you have someone who can and will do it, ask them to follow the above steps and then see or talk to that person daily for a while--so you have someone in your corner.