I just started taking Effexor XR 225mg approx. 5 days ago and since then my sinuses have really been hurting! I was taking 150mg for a few months and then the psychiatrist put me up to 225. Is it a coincidence, or is it a side effect from going up to 225mg? I didn't have this problem back in February when my family doctor doubled my dose from 75mg to 150mg. Maybe I'm just weird....LOL!