Hi - I took SAM-e (it is not an herb..but a dietary supplement) it is an amino acid that our bodies produce naturally, but can stop producing when we get older. It is considered very safe. I took it for three years and it worked wonders, and I suffer from Major depression. A brand I highly recommend is Nature Made. I took 200mg for the first week..and then went to the 400mg. It is a bit on the expensive side, but you can get $7.00 coupons from their website (SAM-e dot com) and also many drugstores or grocery stores offer a "buy one get one free". I would not take SAM-e with St. Johns Wort though..as there can be problems with mixing dietary supplements, sometimes with herbs. There is also a book about SAM-e that you can rent from the library or buy at bookstores, or Amazon dot com, if you would like to read more about it. I have a friend who suffers from severe depression and he has been taking SAM-e (400mg) for about two years and it has worked very well for him. It needs to be taken on an empty stomach at least 45 minutes before a meal. I tried to limit my alcohol consumption when I was on it. Alcohol and antidepressant whether presciption or dietary supplements don't mix well.