Atypical Depression, anyone?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

sweeterthanhoney
Veteran Member


Date Joined Oct 2005
Total Posts : 540
   Posted 3/16/2007 12:27 PM (GMT -7)   
anyone here have atypical depession?  this is something we are looking into for my husband, as he
not responding properly to his meds.  He is currently on 900 mgs of Effexor XR, and it works when it is increased, but after a couple of weeks it starts to slide again. 
 

What Is Atypical Depression?

In addition to the core symptoms of depression, atypical depression is defined by the ability to feel better temporarily in response to a positive life event, plus any two of the following criteria: excessive sleep, overeating, a feeling of heaviness in the limbs and a sensitivity to rejection.

Patients with atypical depression tend to have an earlier age of onset than those with other subtypes (it often first appears in the teenage years). These patients are also likely to have a history of social phobia, avoidant personalities and a history of body dysmorphic disorder.3

How to Treat It

Current data suggests that those with atypical depression will respond better to MAOIs (monoamine oxidase inhibitors) like phenelzine than they will to imipramine (a tricyclic). Dietary restrictions and side-effects remain a problem. At the present time, research is concentrating on finding newer medications with better side-effect profiles to which these patients will also get a good response.4

Although more research is needed, it seems that patients may also obtain an adequate response with the SSRIs, but not all studies seem to back up this assertion. In one study, the SSRI Prozac was found to have a response only equal to imipramine, a tricyclic whose comparative response to phenelzine is well-known.5

Interestingly, however, drug treatment may not be necessary at all. A study conducted in 1999 found that patients receiving cognitive behavioral therapy responded just as well as patients receiving the MAOI phenelzine. 58% of patients in both groups responded, in comparison to only 28% of patients in the placebo group.6

Implications for the Patient

It is important to see a psychiatrist rather than your primary care physician for treatment. Not all depressions are alike nor do they respond to the same medications. A physician in general practice is not likely to have the experience necessary to differentiate between subtypes of depression or to know which treatment choices are more likely to work. A patient may suffer unnecessarily as his doctor tries all the wrong medications. Given the very nature of depression, this only complicates the patient's already depressed feelings. If the patient is forced by insurance or financial circumstances to see a primary care physician for their treatment, they must do the leg work to make up the deficit in their physician's knowledge. This is not as it should be, certainly, but until there is a radical change in our healthcare systems, it is necessary. The educated healthcare consumer who takes an active role in his or her treatment is less likely to slip through the diagnostic cracks.

 


dx: fibromyalgia, IBS-C,Myofacial Pain Syndrome, Chronic Headaches, hypothyroidism,anemia, insomnia,mild depression.
 
Meds:
Clonazapam .25mgs, Oxy IR 2.5-3xs/day 5 mgs at bedtime, Synthroid, Zopiclone, flexeril or baclafen.
 
Supplements:  Licorcise extract, Seriphos, professional vit/mineral, magnesium/malic acid, B#5, probiotic, Ester C
 
Daughter Jerica 17, Dx: Crohn's, Imuran 200 mgs, amitriptyline 20mgs, fish oil, lactaid pills, calcium 1000 mgs/day. Forvia
 
                                      
Jerimiah 29:11                      
 


ShynSassy
Veteran Member


Date Joined Dec 2005
Total Posts : 3036
   Posted 3/16/2007 5:03 PM (GMT -7)   
Hi Sweeter,
I was told that I am a chronic depressant so I do not fit it in with what your husband has.
I hope some other members on here can relate though and you get the help you need.



Shy
Mod- Depression

Chronic Depression, Panic Attacks,Anxiety Attacks,Anorexia

http://www.healingwell.com/donate

"I am woman,hear me roar one day and cry the next!!!"


sweeterthanhoney
Veteran Member


Date Joined Oct 2005
Total Posts : 540
   Posted 3/17/2007 12:40 PM (GMT -7)   
my husband has been told he is OCD, but on another board-depression fallout- the founder said to look into atypical depression, since my hubby isn't responding fully to his meds. When he is in a downer, like he is now, he mostly sleeps. Its 2:39 pm here, and he is still in bed. A number of weeks ago he slept for 30 hrs straight.

Thanks for responding to my posts, Shy, makes me feel not so alone

Sweet
dx: fibromyalgia, IBS-C,Myofacial Pain Syndrome, Chronic Headaches, hypothyroidism,anemia, insomnia,mild depression.
 
Meds:
Clonazapam .25mgs, Oxy IR 2.5-3xs/day 5 mgs at bedtime, Synthroid, Zopiclone, flexeril or baclafen.
 
Supplements:  Licorcise extract, Seriphos, professional vit/mineral, magnesium/malic acid, B#5, probiotic, Ester C
 
Daughter Jerica 17, Dx: Crohn's, Imuran 200 mgs, amitriptyline 20mgs, fish oil, lactaid pills, calcium 1000 mgs/day. Forvia
 
                                      
Jerimiah 29:11                      
 


LondonGirl22
Veteran Member


Date Joined Jan 2006
Total Posts : 1629
   Posted 3/17/2007 1:21 PM (GMT -7)   
900mgs????

I thought the highest dose of effexor was 375mg.

I take 150mg of effexor for depression and anxiety myself. I don't know much about atypical depression so your post was interesting to read.

Victoria x

Moderator ~ Depression and Anxiety Forum

Xx Sometimes we all have to go a little crazy just to stay sane xX


sweeterthanhoney
Veteran Member


Date Joined Oct 2005
Total Posts : 540
   Posted 3/17/2007 1:47 PM (GMT -7)   
yes, Victoria, you read right. He is on 900 mgs of Effexor. He seems to be an ultra rapid metabolizer. His pdoc is even going to be contacting the manufacturer on this med. Of all the ones hes taken, it is the only one that has helped like it has. You think with that dose he'd be comatose, but he isn't. When he is feeling good, he functions perfectly fine.

The side effects he does have are perfuse sweating[he says he can live with that if he feels better] constipation, some sexual difficulties, and when he feels good, doesn't need as much sleep.

I have been very conserned with the dosage, but his pdoc doesn't seem to be concerned at all. There is an enzyme our body makes that is needed to metabolize certain meds, and when it isn't there, or there are 2 many copies or something isn't right with it, then there are metabolizm problems

here are a couple of links to info on this

http://www.signaturegenetics.com/public/3/311.html

http://www.healthanddna.com/

if this is a problem you can delete these links, but they aren't selling anything.
dx: fibromyalgia, IBS-C,Myofacial Pain Syndrome, Chronic Headaches, hypothyroidism,anemia, insomnia,mild depression.
 
Meds:
Clonazapam .25mgs, Oxy IR 2.5-3xs/day 5 mgs at bedtime, Synthroid, Zopiclone, flexeril or baclafen, L-tryptophan
 
Supplements:  Licorcise extract, Seriphos, professional vit/mineral, magnesium/malic acid, B#5, probiotic, Ester C, P5P[B6 supplement]
 
Daughter Jerica 17, Dx: Crohn's, Imuran 150 mgs, amitriptyline 20mgs,   lactaid pills, calcium 1000 mgs/day. Forvia, waiting for first Remicade infusion
 
 Husband with treatment resistant depression   Effexor-900mgs
 
                                     
Jerimiah 29:11                      
 


vmarier
Regular Member


Date Joined Jan 2007
Total Posts : 59
   Posted 3/25/2007 9:27 AM (GMT -7)   
I checked this forum because I have been doing moderately well with Cymbalta and Lexapro but now I'm having periods of pain, anxiety and depression. Atypical depression sounds like me with the early onset in adolescence and the abiity to tolerate high doses of psychotropic drugs. I'm on 30 mg lexapro, 60 mg. Cymbalta and 100 mg. Lamictal. Anyone else would probably be in the throes of serotonin syndrome. My depression also has a genetic component. My mother also had treatment resistant depression. Her experience was years ago when the SSRI's and new drugs didn't exist.

dx: FM, IBS-C/G/D, Myofascial Pain Symdrome, Costochondroiti***, Headaches and Migraines, hypothyroidism, sleep apnea, Seasonal Affective Disorder, Type II Diabetes, Metabolic Syndrome

sweeterthanhoney
Veteran Member


Date Joined Oct 2005
Total Posts : 540
   Posted 3/25/2007 3:55 PM (GMT -7)   
vmarier,

have you found AD's to help your FM? I've had no luck with that, and in fact had a horrible time getting off Effexor!
dx: fibromyalgia, IBS-C,Myofacial Pain Syndrome, Chronic Headaches, hypothyroidism,anemia, insomnia,mild depression.
 
Meds:
Clonazapam .25mgs, Oxy IR 2.5-3xs/day 5 mgs at bedtime, Synthroid, Zopiclone, flexeril or baclafen, L-tryptophan
 
Supplements:  Licorcise extract, Seriphos, professional vit/mineral, magnesium/malic acid, B#5, probiotic, Ester C, P5P[B6 supplement]
 
Daughter Jerica 17, Dx: Crohn's, Imuran 150 mgs, amitriptyline 20mgs,   lactaid pills, calcium 1000 mgs/day. Forvia, waiting for first Remicade infusion
 
 Husband with treatment resistant depression   Effexor-900mgs
 
                                     
Jerimiah 29:11                      
 

New Topic Post Reply Printable Version
Forum Information
Currently it is Sunday, December 11, 2016 1:09 AM (GMT -7)
There are a total of 2,736,238 posts in 301,363 threads.
View Active Threads


Who's Online
This forum has 151453 registered members. Please welcome our newest member, LvGuy1.
176 Guest(s), 1 Registered Member(s) are currently online.  Details
bluelyme


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2016 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer