Different brands of Mirtazapine-Different reactions.

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Gemsi
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Date Joined Feb 2007
Total Posts : 1050
   Posted 8/13/2007 7:08 AM (GMT -7)   
Hi there!
 
Has anyone else experianced different levels of tiredness, depending which brand of Mirtazapine they've used?
 
There are 3 different brands I get, depending which pharmacy I go too. I find one brand completely and utterly knocks me out. I can't even keep my eyes open 5 minutes after taking it. The second brand don't really have any effect like that on me. Both of these brands have the same colour coatings, about the same shape and size.
The third one is brand name-Zispin. It's an oral dispersable tablets, that tastes kinda cool. This brand works best for me, it's knocks me out like tablet one, but elevates my mood better than the other 2 brands.
 
They're all 30mg tablets, it's weird that they are so different.
Anyone else experiance this?


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Post Edited (Darkies Gem) : 8/13/2007 8:14:56 AM (GMT-6)


stkitt
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Date Joined Apr 2007
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   Posted 8/13/2007 8:34 AM (GMT -7)   

Hey Gems

Hi Sweetie, I am sorry your having this problem.

To the best of my knowledge generic medications have the same active ingredients, the same dosage form (tablets, capsules, suspension, and syrup) and are identical in the strength or concentration to brand name medications.

They may look different in shape, size and colors. There are strict guidelines that the generic medication has to meet in order to be called therapeutically equivalent and be marketed to you.

To be approved by the Food and Drug administration here, the amount of medication absorbed and the time that it takes the medication to be absorbed by the generic has to be within a certain percent of the brand name medication.

Even with these guidelines, there may be small differences between medications manufactured by different companies. In most  cases, these differences will not dramatically change the way people respond to the medicine, but, in some people, even these small differences may be important. Usually, if a person can be kept on the same manufacturer’s product, they can be effectively and safely treated.

Reference: Rex S. Lott, Pharm.D. Professor of Pharmacy Practice

 


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Post Edited (stkitt) : 8/13/2007 9:56:28 AM (GMT-6)


Gemsi
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Date Joined Feb 2007
Total Posts : 1050
   Posted 8/13/2007 9:07 AM (GMT -7)   
Thanks for that Kitt. I think from now on, I'm going to request Zispin. It's nice sometimes having a medication that just dissolves on your tongue. Rather than thinking of it as another tablet too take. Plus it does seem to work slightly better, and perhaps because of the way it is dispersed on your tongue, it maybe absorbed better. I still can't understand why there is such a huge difference between the other 2 brands.
I suppose, it's kind of like inhalors. Salbutamol 3M inhalors work better if your really struggling to een breathe in. Where as Ventolin works better if your only slightly asthmatic. Both spray inhalors, both give the same drug. But there is a slight difference in there design that makes all the difference.I guess this could be the same with oral medication.
Co-moderator in the: Cystic Fibrosis Forums
 Woe to the child which when kissed on the forehead tastes salty. She is bewitched and soon must die.
 Diagnosed with: Cystic Fibrosis, Asthma, ABPA, Clinical Depression, Mild liver cirrohsis, mild osteopenia. Waiting for final diagnosis on Muscular Dystrophy type symptoms.
 Medication: Creon 10,000, Flucloxacillin, Vitamins A,D+E, Tobi nebuliser, Serevent, Salbutamol, Sertraline, Odansetron, Nefopam, Ciprofloxacin, Ursodeoxycholic Acid, Omeprazole.
Had a Port-a-cath fitted on chest wall since 11th Nov 05


Aurora60
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Date Joined Jul 2006
Total Posts : 1249
   Posted 8/13/2007 9:50 AM (GMT -7)   

Hi Gem,  I take Mirtazapine 45 mgs by Mylan. It is a generic.  I take it at night because it does make you tired.  My Dr. told me it is more sedating at lower doses such as 30 mg.  What time do you take your med?  If you are taking it during the day maybe you should switch to nightime.  This may help and it will help you get to sleep.  Hope my experience with this med helps.  I have been taking it for about 5 years.

Aurora


els
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Date Joined Oct 2005
Total Posts : 4031
   Posted 8/13/2007 2:59 PM (GMT -7)   
Hey Darkies,  My doc put me on Remeron (mirtazapine) 30 mg  - 1/2 tab at night the dissoluble tabs that fizzed up as soon as you put it in your mouth.  Of course this was like 10 years ago but seriously, no soon did I take it and I would have trouble finding my bedroom.  Less then 2-3 minutes later and I was totally drugged.  I tried to stick with it but I couldnt not even long enough to see if it would help with my depression.  I couldnt even stay awake during the day.  I guess it was just too strong for me...dont know? 
 
 

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fiberman
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Date Joined Sep 2007
Total Posts : 2
   Posted 9/28/2007 7:39 PM (GMT -7)   
SUBJECT: Varying sedation effects of different mirtazapine brands

Greetings,

As a sleep aid, for 3 years I took the same mirtazapine brand (30 mg, disc-shaped, brown with number 93 on one side and 7207 (or something close) on the other. It worked very well at 15 mg (I split the pills). But, I was just switched to a new brand of 30 mg tablets (disc shaped, beige with M530 on one side. The manufacturer is Mylar, but these tablets don't seem to work. Has anyone else had a similar experience with these 2 brands? Thank you.

djdaz_1985
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Date Joined Jan 2006
Total Posts : 2408
   Posted 9/29/2007 2:08 AM (GMT -7)   
Hi there,
 
I can only speak for the licencing in the UK, but different brands of the same drug MUST BE equivilent. I.e. They must have the same active ingredients and should have the same effects as easch other. I dont understand how 2 brands of the same drug can be so different, but I know it does happen. Have you told the doctor about this? It sounds like the licencing people need to be informed that the drugs are NOT equivilent and your doctor is the best person to do this since he has authority.
 
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fiberman
New Member


Date Joined Sep 2007
Total Posts : 2
   Posted 9/29/2007 7:59 AM (GMT -7)   
GENERICS: Pharmacological equivalence doesn't necessarily = clinical equivalence

A Canadian study has revealed that generics are not always clinically equivalent to the brand name.
 
Reason for edit
 
I have taken the study that you posted out for 2 reasons. One is that you have published contact information on a public forum which belongs to someone else and the other is that the forums were not designed with publishing studies in mind. There is nothing wrong with sharing information however. (Please see Rule #9 and #15 --> http://www.healingwell.com/community/default.aspx?f=46&m=106997)
 
Darren

Post Edited By Moderator (djdaz_1985) : 9/29/2007 9:25:31 AM (GMT-6)

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