Metformin Nightime Nausea Help?

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Veebo
Regular Member


Date Joined Nov 2007
Total Posts : 147
   Posted 4/20/2009 9:48 PM (GMT -6)   
Hi Folks I am wondering if anyone has any tips or tricks regarding avoiding nausea while on glucophage/metformin. I am on the medication for PCOS. I also have Celiac and Crohn's disease so I am on a strict gluten free diet. I first started on Metformin in September 2007. I had no major issues with it until this past fall. I started getting nauseous everyday around 4 pm. It would continue all night long completely hampering me from eating any snacks or dinner. It got so bad that I could not even stand the smell of food (much like when you have a nasty stomach virus). It felt like my food was not moving past my stomach and would just sit there for hours and it would resolve temporarily with Reglan but would come back the next day. My GI did a gastric emptying study which was normal. What drives me nuts is that I am perfectly fine in the morning and have no issues eating breakfast. Anyway, I stopped the meds in January and I have felt great off of them except that all my PCOS symptoms are rearing their ugly heads again. My endo started me on extended release metformin which I have been on for the past two days and again...nighttime nausea. I do take the pills with food. I am wondering if it is caused by some kind of hormone shift or not eating at the right time. If anyone has any tricks that may help with this I would love to hear what they are as I am getting less and less inclined to stay on this awful med.

Thanks!

ceebee
Regular Member


Date Joined Dec 2006
Total Posts : 401
   Posted 4/21/2009 1:20 AM (GMT -6)   
Try taking it with a meal. I do and have no nausea. I did get nausea with an emty stomache. Good luck:)

uniquelyme
Veteran Member


Date Joined Nov 2008
Total Posts : 1036
   Posted 4/21/2009 8:02 AM (GMT -6)   
 
 
Veebo,
Hi, I understand how you feel. I take, or rather took Metformin for Type 2 Diabetes (just diagnosed March 16, 2009), I started out on just 500 mg. a day, and went up to 2000 mg. a day.  I just talked to my Dr. yesterday and told him abou my nausea issues..He changed me to Metformin XR...I have only taken it once, but so far not as bad...Maybe you should ask about it for you...
 
Good Luck,
Me.

 
We are all in the same boat...unfortunatley it seems like it's sinking...
Post Lamenectomy Syndrome
Hemi Lamenectomy/Spinal Fusion(Lumbar)
60 mg. MS Contin 2Xdaily/15 mg. Oxycodone as needed
High Blood Pressure: Lisinopril HCTZ 10 mg. daily
Type 2Diabetes: (March 16, 2009)
Metformin 1000mg. twice daily (so far)
ME. (Rhonda)                                                                    

 


Veebo
Regular Member


Date Joined Nov 2007
Total Posts : 147
   Posted 4/21/2009 8:59 AM (GMT -6)   
Hi There,

Thanks for the replies. I actually just started extended release metformin this week and that is still causing the nausea for me in the evening. I always take it with food as well so I am not sure if there is anything that can be done. What is weird is that I would think that nausea from the actual medication would occur within a few hours of taking it and not 8 hours later. I am currently only taking 500mg once a day and that will be built up to 1000mg in the next two weeks.

Thank You

Jeannie143
Veteran Member


Date Joined Apr 2004
Total Posts : 6047
   Posted 4/21/2009 2:01 PM (GMT -6)   
Veebo,
I only wish I could borrow your symptoms! Night time is my hardest time to stay on track and when most of my control issues appear with over indulgences. If I were you I'd tailor my eating schedule to the med for a while and just eat my food before noon. My husband only eats once a day, has for over 30 years and he's just fine. Try it and see if it works?
~ Jeannie, Forum Moderator/Diabetes & Fibromyalgia
I know God will not give me anything I can't handle. I just wish that He didn't trust me so much. ~Mother Teresa

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."- Elizabeth Kubler-Ross


Veebo
Regular Member


Date Joined Nov 2007
Total Posts : 147
   Posted 4/21/2009 7:12 PM (GMT -6)   
So I did an experiment today.  I typcially snack during the day and eat things like rice crisps or baked lays and then eat a yogurt a bit later in the day.  Today I had a greek yogurt and put some walnuts in it...a little later I had some melon...wouldn't you know I had no nausea.  Now I could just be adjusting to the meds but it makes me wonder if I am super sensitive to high carb foods when taking the Metformin.  I really want to stay on the meds this time because I would like to get pregnant some time in the near future.  But if I have to go through all the nausea and pain that I had last time around I am not sure I will be able to tough it out.  What made it so bad is that I could not even stand the smell or thought of food.  I am going to try the high protein deal again tomorrow and see if I can get two days nausea free. :-)

LanieG
Forum Moderator


Date Joined Nov 2006
Total Posts : 3039
   Posted 4/21/2009 7:49 PM (GMT -6)   
Hi Veebo, I am not on meds, so other members here who are can give you the best advice for them, but what has struck me in your post is the amount of carbs you've been eating.  Food like the rice crisps and potato chips will keep your blood sugar high which in turn will increase the need for meds.  The yogurt and walnuts have protein and fats (from the nuts anyway if the yogurt is fat-free) and shouldn't give you as bad a rise.  Good snacks for diabetics or anyone with high blood sugar would be cheese, nuts, sugar-free or plain yogurt, eggs or even deli-style meat slices.  I'm not sure what diet restrictions you have because of Celiac and Crohn's but if you reduced the amount of carbs, I know the blood sugar would be lower.  As you know, testing is the best way to see how your blood sugar reacts to the food you're eating.  Good luck. 

Lanie
forum moderator - diabetes
diabetes controlled so far by low/no carb diet and exercise; no meds


ceebee
Regular Member


Date Joined Dec 2006
Total Posts : 401
   Posted 4/22/2009 12:30 AM (GMT -6)   
Veebo,

It is definitely the carbs. Metformin does not like carbs. Keep on the low carb eating and I bet the nausea will go with them:) Every once in a while, I will eat more carbs and do get the nausea and it isn't even that many more carbs either. Good luck:)

Veebo
Regular Member


Date Joined Nov 2007
Total Posts : 147
   Posted 4/22/2009 7:15 AM (GMT -6)   
Hello,
 
So my awake hours were good yesterday...no real nausea.   However, I had awful night sweats and chills and middle of the night nausea.  I am starting to think that I just simply can not tolerate the metformin anymore.  Low carbs did seem to help yesterday so I am going to do it again today.  As a side note I do not have diabetes so low carb is not really a mandate for me.  I have polycystic ovarian syndrome and I am taking the metformin to help balance out my hormones (it does wonders).  My blood sugar is actually normal so I always try to eat some carbs while taking metformin in an effort to keep it from going low.  Either way low carb can be beneficial to those with PCOS since it is often accompanied by insulin resistance (which I do not have).  I came seeking help from the diabetic board since I figured you folks would know better than anyone the way in which these meds impact your body.  I appreciate all your responses :)
 
Thank You 

Jeannie143
Veteran Member


Date Joined Apr 2004
Total Posts : 6047
   Posted 4/26/2009 6:19 PM (GMT -6)   
I have been thinking about this and reading what the others are saying and I'll bet if you skip the obvious carbs and only eat lots of veggies, some fruits, nuts, cheese, eggs and meat you will find that the metformin becomes trouble free. Eating carbs with metformin can lead to horrible diarrhea. My doc, when I was first prescribed metformin, told me that "If you over do, you go pooh!"

Everytime I find myself with a bad bout of tummy problems a quick check back over my recent food choices will show me the error of my ways. Hope this helps.

Also, hope you can get pregnant. A baby is really a neat way for God to grow a person.
~ Jeannie, Forum Moderator/Diabetes & Fibromyalgia
I know God will not give me anything I can't handle. I just wish that He didn't trust me so much. ~Mother Teresa

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."- Elizabeth Kubler-Ross


Nana25
New Member


Date Joined May 2009
Total Posts : 1
   Posted 5/21/2009 6:00 PM (GMT -6)   
Hello everyone!
 
I am so glad I found this posting! Ive been on metformin ER for about a month now, and ive gradually moved up to 1500mg per day for Insulin Resistance, and I have had the absolute worst nausea. And whats worse is that it is all day long, the smell of food repulses me, but i have to take it with food, which in turn makes it worse. It ges so bad at night that I cant sleep, and my doc says its relatively normal. Ive cut down my carbs tremendously, but I will admit Ive been slacking a bit lately. I am going to try and snack on low carb foods and see if that helps....Thanks all!!

Jeannie143
Veteran Member


Date Joined Apr 2004
Total Posts : 6047
   Posted 5/23/2009 7:47 PM (GMT -6)   
You're welcome. Don't be a stranger. We like new friends here.
~ Jeannie, Forum Moderator/Diabetes & Fibromyalgia
I know God will not give me anything I can't handle. I just wish that He didn't trust me so much. ~Mother Teresa

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."- Elizabeth Kubler-Ross

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