One of the reasons Drs ramp up the dosage slowly from 500 up to whatever they really want you to take is because of the stomach and bowel reactions. As Lanie says, it seems to make a difference what you eat -- and for me, it matters how much I eat. If I don't eat enough while taking metformin, my body tells me about
it in a not-so-nice manner.
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2002DIAGNOSING LUPUS & HW's LUPUS 101
"Life is far too important to be taken seriously." - Oscar Wilde