Chromium Pic to reduce glycemic index??

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kim123
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Date Joined Jul 2006
Total Posts : 1201
   Posted 8/22/2006 5:42 PM (GMT -7)   
Hi all,
Just heard something interesting on a health show today "Know The Cause" with Doug Kaufmann,that chromium pic improves glycemic index in Type II Diabetes. Was a study mentioned in the "Diabetes Care" Aug. 2006 journal. Supposedly it makes your insulin work right. Has anyone else heard of this or something similar? They commentators mentioned that some people who had been on it for as little as one week noticed a drop in blood sugar levels. Just thought it was interesting enough to bring to the table. Can't speak from personal experience. Til later...
Kim

spooky
Regular Member


Date Joined Jan 2006
Total Posts : 101
   Posted 8/22/2006 8:50 PM (GMT -7)   
Hi there,
Despite widespread use by patients with diabetes and anecdotal reports in the past regarding its efficacy, until recently, data in humans concerning chromium’s effects on insulin action in vivo or on cellular aspects of insulin action were scarce. Consequently, significant controversy still exists regarding the effect of chromium supplementation on parameters assessing human health. Furthermore, elucidating the cellular and molecular mechanisms by which chromium supplements affect carbohydrate metabolism in vivo is necessary before specific recommendations can be made regarding its routine use in the management of diabetes.

Chromium (Cr3), a trace element in its trivalent form, is required for the maintenance of normal glucose metabolism. Experimentally, chromium deficiency is associated with impaired glucose tolerance, which can be improved with supplementation (35). Most individuals with diabetes, however, are not chromium deficient.

I will get back to you with more info'

Claire-Bear
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Date Joined Oct 2005
Total Posts : 242
   Posted 8/23/2006 1:16 AM (GMT -7)   
I'm sure there have been previous posts about chromium and how toxic it is...pretty sure it was Warren.  I'll look back and see if I can find anything

Claire-Bear
Regular Member


Date Joined Oct 2005
Total Posts : 242
   Posted 8/23/2006 8:58 AM (GMT -7)   

Hi,

Found these links regarding Chromium Picolinate...

http://www.dietitian.com/chromium.html

http://www.pponline.co.uk/encyc/0066.htm

I just googled, if you want any more info.

Claire x


spooky
Regular Member


Date Joined Jan 2006
Total Posts : 101
   Posted 8/23/2006 5:45 PM (GMT -7)   
Hi there Kim,
yes,there is a paper published in the august issue of Diabetes Care journal.I quote"Chromium picolinate (CrPic) supplementation improves glycemic control in patients with type 2 diabetes not adequately controlled while taking sulfonylurea, according to the results of a randomized, double-blind study reported in the August issue of Diabetes Care"
"After baseline evaluation, 37 subjects with type 2 diabetes were treated with a sulfonylurea (glipizide gastrointestinal therapeutic system, 5 mg/day) with placebo for 3 months. These subjects were then randomized in a double-blind fashion to receive for 6 months either the sulfonylurea plus placebo (n = 12) or the sulfonylurea plus 1000 μg of chromium as CrPic (n = 17). End points included body composition, insulin sensitivity, and glycemic control at the end of the 3-month single-blind placebo phase and at study end"
"This study demonstrates that CrPic supplementation in subjects with type 2 diabetes who are taking sulfonylurea agents significantly improves insulin sensitivity and glucose control," the authors write. "Further, CrPic supplementation significantly attenuated body weight gain and visceral fat accumulation compared with the placebo group.... The mechanisms for these findings are not precisely known, but clinical research studies addressing dietary intake, skeletal muscle fat oxidation, and insulin signaling are ongoing."
Thus Chromium acts by increasing Insulin sensitivity and reducing visceral fat mass and also body weight.This appears to be a paradigm shift in the concept on Chromium picolinate.

spooky
Regular Member


Date Joined Jan 2006
Total Posts : 101
   Posted 8/23/2006 6:10 PM (GMT -7)   

Hi there,

             Warren was concerned about the carcinogenic effects of chromium picolinate.For those who are serious about the safety of the molecule,it can safely be said to be non-carcinogenic,based on the available material.Iam posting a link below.Please read:

http://www.advisorybodies.doh.gov.uk/com/chromium.htm


kim123
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Date Joined Jul 2006
Total Posts : 1201
   Posted 8/23/2006 6:51 PM (GMT -7)   
Thank you spooky for taking time to research that. You're awesome. So, what does that mean to people who have type II? Should this be something they try? By the way, where can someone like me look something like that up themselves?...online???
Kim

Jeannie143
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Date Joined Apr 2004
Total Posts : 6056
   Posted 8/24/2006 7:15 AM (GMT -7)   
Kim,
Go to www.dogpile.com (it's a mondo search engine that searches about 24 other search engines) and put in "chromium picolinate, Diabetes type 2, research" or something like that. Ignore all of the links to places selling the stuff. A lot of times I will put in the word 'university' in my search and I'll get more official results instead of companies trying to sell me something. Hope this helps.
~ Jeannie

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."

- Elizabeth Kubler-Ross


Chutsman
Regular Member


Date Joined Jul 2005
Total Posts : 64
   Posted 8/25/2006 1:08 PM (GMT -7)   
I have tried Chromium Picolinate off and on.  Sometimes it seems to be effective, sometimes not.  So I would stop it for a while, then maybe a month or two later I would get some again.  I am on Glucophage - two by 500mg daily.
The short form for "you are" is "you're", NOT "your".


Warren
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Date Joined Oct 2005
Total Posts : 534
   Posted 8/27/2006 7:40 AM (GMT -7)   
There are so many people that are willing to sell you anything to make a buck.  Unfortunately, this happens more often to people with serious conditions where they are constantly grasping at anything that will improve their condition, short of traditional medicine.
 
Chromium Supplementation just doesn't work, and in the very worst case scenarios, it can be seriously dangerous to your health.  Almost every "study" or "proof" that it is non-harmful or beneficial comes from groups that ultimately have a vested interest in selling or manufacturing a product.  The contrarian studies come from organizations such as the American Diabetes Association and the National Acadamy of Sciences.
 
The biggest problem with Chromium supplementation is that you have to take a substanial dose to see any type of results.  The much touted "herbal" remedy "Diabetecine" had a dosage that approached 1000mcg a day.  This is precisely the area that is the danger zone that most of the toxicity studies talk about. (coincidently it is also the range where any blood glucose lowering results begin to occur).
 
So, aside from "Diabetecine" which has been shut down by the FDA and the FTC for false advertising, no one claims that chromium is a cure for Diabetes.  This being the case, WHY WOULD YOU TAKE THE RISK of using something with nebulous results and very possibly deadly consequences.  For those of you that like to read research, I'll supply the following links to real information and studies by reputable organizations.  Im not here to debate chinese studies in mice and humans, but simply to say that you are much better off taking a known drug like BYETTA, that can increase your beta cell mass and return your blood glucose levels to normal than you are flirting with an over the counter mineral that could do serious damage to you.
 
 
 
 
 
. . . and the list goes on.   My point is simply this: On the Risk/Reward scale, Chromium in its many over the counter forms, doesn't provide enough "reward" to warrant the potential risks.
 
scool Warren
 
 

Post Edited (Warren) : 8/27/2006 8:47:23 AM (GMT-6)


kim123
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Date Joined Jul 2006
Total Posts : 1201
   Posted 8/30/2006 4:31 PM (GMT -7)   
Well, all I can say, he helped me get my life back. Everyone is entitled to their own opinion, that's for sure. What a great country!

I'm wondering if you have ever tried any of his,(as well as the doctors who agree with him), advise. To tell you the truth, I was VERY skeptical myself when I first heard him too. It took me 6 months to actually buy his book, follow his phase 1 diet, (very close to SCD), and almost immediately I got relief from 13 years of miserable Ulcerative Colitis. I am now symptom free.I don't believe that "everyone" will be "healed" by doing what he has to say, but I do believe that for people who are legitimately suffering from a fungus, and yes, it is real, that they can be helped significantly. I guess it is up to each person to decide if they want to try something different, even if it seems unlikely, and then go in peace. Did you actually try what he said? I know that many people have been helped by him, so there has to be something to it.
Wishing you health...

kim123
Veteran Member


Date Joined Jul 2006
Total Posts : 1201
   Posted 9/1/2006 1:20 PM (GMT -7)   
I did hear that they were getting a new website soon. Don't know if that is why everything is shut down right now... Nice to hear your point of view.

kim123
Veteran Member


Date Joined Jul 2006
Total Posts : 1201
   Posted 9/1/2006 1:28 PM (GMT -7)   
here's the abstract I refered to on my original post...






--------------------------------------------------------------------------------

Diabetes Care 29:1826-1832, 2006
DOI: 10.2337/dc06-0254
© 2006 by the American Diabetes Association


Articles by Martin, J.
Articles by Cefalu, W. T.


--------------------------------------------------------------------------------


Chromium Picolinate Supplementation Attenuates Body Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes
Julie Martin, MS, RD1, Zhong Q. Wang, MD2, Xian H. Zhang, BS2, Deborah Wachtel, NP, MPH1, Julia Volaufova, PHD3, Dwight E. Matthews, PHD1 and William T. Cefalu, MD2
1 Division of Endocrinology and Metabolism, University of Vermont, Burlington, Vermont
2 Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana
3 Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana

OBJECTIVE—Chromium picolinate (CrPic) supplementation has been suggested to improve glycemia, but there are conflicting reports on efficacy. We sought to determine the effect of CrPic on insulin sensitivity, glycemic control, and body composition in subjects with type 2 diabetes.

RESEARCH DESIGN AND METHODS—Thirty-seven subjects with type 2 diabetes were evaluated. After baseline, subjects were placed on a sulfonylurea (glipizide gastrointestinal therapeutic system 5 mg/day) with placebo for 3 months. Subjects were then randomized in a double-blind fashion to receive either the sulfonylurea plus placebo (n = 12) or the sulfonylurea plus 1,000 µg Cr as CrPic (n = 17) for 6 months. Body composition, insulin sensitivity, and glycemic control were determined at baseline, end of the 3-month single-blind placebo phase, and end of study.

RESULTS—Subjects randomized to sulfonylurea/placebo, as opposed to those randomized to sulfonylurea/CrPic, had a significant increase in body weight (2.2 kg, P < 0.001 vs. 0.9 kg, P = 0.11), percent body fat (1.17%, P < 0.001 vs. 0.12%, P = 0.7), and total abdominal fat (32.5 cm2, P < 0.05 vs. 12.2 cm2, P < 0.10) from baseline. Subjects randomized to sulfonylurea/CrPic had significant improvements in insulin sensitivity corrected for fat-free mass (28.8, P < 0.05 vs. 15.9, P = 0.4), GHb (–1.16%, P < 0.005 vs. –0.4%, P = 0.3), and free fatty acids (–0.2 mmol/l, P < 0.001 vs. –0.12 mmol/l, P < 0.03) as opposed to sulfonylurea/placebo.

CONCLUSIONS—This study demonstrates that CrPic supplementation in subjects with type 2 diabetes who are taking sulfonylurea agents significantly improves insulin sensitivity and glucose control. Further, CrPic supplementation significantly attenuated body weight gain and visceral fat accumulation compared with the placebo group.


Abbreviations: AUC, area under the curve • AUC-B, glucose AUC from the fasting glucose at time 0 • CrPic, chromium picolinate • DEXA, dual-energy X-ray absorptiometry • FFA, free fatty acid • GITS, gastrointestinal therapeutic system • OGTT, oral glucose tolerance test










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