The article you posted talks about rosiglitazone (AVANDIA). This belongs to the class of drugs called thiazolidinediones. The other major drug in this class is ACTOS. In very simple terms, what these drugs do is increase a persons sensitivity to insulin by attaching to the insulin receptors throughout a persons body and INCREASING the sensitivity to insulin in the bloodstream, thus allowing more sugar to be removed.
The side effect most normally observed is "swelling" of the legs or arms due to fluid retention. This is really dangerous for heart patients. But aside from this there is a real potential for liver damage. The link for this is tenuous but most endocrinologists will make you have a liver panel every 30 days while using the drug. With these two side effects, I'd be hard pressed to say ANYONE should take this drug as a PREVENTATIVE. I was taking this drug for about a year and when I started taking Byetta it was the first oral med my doctor got rid of! (and yes, I suffered from the fluid retention. Complained about it and my doctor said, would you rather have fluid retention or high blood sugar. Grrrrrrr!)
In any event, this drug has been around for awhile and I would think twice before using it for anything but really uncontrolled type 2 diabetes.