Concerned about beginning Byetta injections.

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jkirkman
Regular Member


Date Joined Nov 2006
Total Posts : 20
   Posted 11/18/2006 9:50 AM (GMT -7)   
Hi-
 
I am new here to these message boards and have a lot of concerns about starting Byetta.
 
Do any of you have bad side effects from it, like nausea/lack of appetite? I've heard that is
a very frequent symptom and have read that a lot of people have that problem here. Does it last
for some of you, or go away? I'd like to learn more.
 
How about hypoglycemia with it? Anyone have that problem of feeling "shocky" on Byetta? confused Any advice you have out there would be welcome. I feel a little apprehensive starting Byetta
therapy. I've taken diabetic pills for years, which are Actos, Metformin, and Glucotrol. But my sugars
go into the high 150's and even up into the 200's too often. So that is why my doctor and I decided
to try this and see what it does for me.
 
Share your story with me-I would love to hear!
 
Jkirkman eyes

Jeannie143
Veteran Member


Date Joined Apr 2004
Total Posts : 6056
   Posted 11/18/2006 6:48 PM (GMT -7)   
J,
We have a number of Byetta users on the forum and they should be by soon to answer your questions. If you don't get any answers in a day or so I'll send out the Marines to haul them in for you.

Myself, I'm on Lantus insulin, 10 - 15 units at bedtime and it's worked wonders with my numbers. I was doing the 150 to 200 dance just like you and now I awaken with 88's and 103's. Lantus is still insulin and Byetta acts differently and also seems to spur the body to hang on to it's islet cells longer. You should probably read back in the posts and see what others are saying about Byetta. That will help you a lot when it comes to fears about starting it.
~ Jeannie

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."

- Elizabeth Kubler-Ross


jkirkman
Regular Member


Date Joined Nov 2006
Total Posts : 20
   Posted 11/19/2006 6:15 PM (GMT -7)   
Thanks Jeannie for your reply! Does Lantus make you put on a lot of weight? My doctor and I were worried about that. I've also heard that Lantus is peakless, but then I've heard otherwise too. So what to believe-I don't know. Does it give you hypoglycemic problems?
Jennifer
 
:-)  

Warren
Veteran Member


Date Joined Oct 2005
Total Posts : 534
   Posted 11/20/2006 10:39 AM (GMT -7)   

Byetta is almost guaranteed to make you nauseous; TWICE.  Once when you start the 5mg dose and again probably worse when you start the 10mg dose.  MOST people experience the nausea, usually for at least a week; although we've had some go for almost 2 months and some that had to just plain quit Byetta because of the nausea.  In most cases it will pass; try to limit your carb intake and it tends to make it easier.

If you are taking Actos, Meformin and Glucatrol, you will probably have to drop the Actos and cut the doseage of the others in half at the 10mcg level of Byetta or the drug will surely drop you blood sugar into the low 50's on a regular basis. (thats the shocky feeling you refer to). 

If all else fails and you can't deal with the nausea, there are some new drugs on the market that are "orals" that don't have nausea as a side effect that do much the same thing as Byetta, just not as well (so if you can deal with the Byetta, for now you are better off with it).

scool Warren

Jeannie143
Veteran Member


Date Joined Apr 2004
Total Posts : 6056
   Posted 11/20/2006 11:54 AM (GMT -7)   
Actually, I've lost weight since I started the Lantus but that is probably because I'm paying better attention to my diet and exercise regimen. I've never had a low blood sugar with it. I also take 1000 mg glucophage and 2 mg avandia in the morning and again at night. I spent about 20 minutes looking up all the old byetta links for you yesterday and then lost the post when I got up to fix dinner. Forgot I had started it and put the computer down for the night. (Grrrrrrr! I HATE it when that happens!) I'll try to get those posts listed for you again.
~ Jeannie

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."

- Elizabeth Kubler-Ross


jkirkman
Regular Member


Date Joined Nov 2006
Total Posts : 20
   Posted 11/20/2006 12:31 PM (GMT -7)   
Thanks Jeannie again for another great reply! I appreciate your help. I will be glad when I can start my Byetta, (once I'm approved through patient assistance). I just hope it doesn't do anything to make me too sick.
 
It is nice having a great chat friend like this-the support from someone who knows helps!
 
Jennifer
 
 

Jeannie143
Veteran Member


Date Joined Apr 2004
Total Posts : 6056
   Posted 11/20/2006 1:01 PM (GMT -7)   
These are the ones I could find:

Byetta

Traveling with Byetta

Byetta

You have this problem with byetta?

Byetta lows

byetta (morning highs)

Byetta Question from a newbie

Byetta question for Warren

Byetta 1st shot

When to take byetta

Byetta first timer

Byetta 10 is making me soooo sick

Byetta spikes and companion meds

When to take medication

Byetta Storage
~ Jeannie

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."

- Elizabeth Kubler-Ross

Post Edited (Jeannie143) : 11/20/2006 1:04:20 PM (GMT-7)


Jeannie143
Veteran Member


Date Joined Apr 2004
Total Posts : 6056
   Posted 11/20/2006 1:04 PM (GMT -7)   
Here are some more:

Two week success

How to tell when the pen is empty

concern

Byetta (Prosper)

7/05

Just started using byetta
~ Jeannie

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."

- Elizabeth Kubler-Ross


jkirkman
Regular Member


Date Joined Nov 2006
Total Posts : 20
   Posted 11/24/2006 6:21 PM (GMT -7)   
Hi Jeannie!

Hope you had a great Turkey Day! Thanks for more info there. I am finding it very helpful so far. Anything else you see on the web for Byetta, just keep on letting me know.

Thanks again!

Jennifer

azle
New Member


Date Joined Nov 2006
Total Posts : 4
   Posted 11/28/2006 10:09 AM (GMT -7)   

Concerns, I have been on B since July 06 no real problems I went on 10 about three months ago. I have not experienced any low bouts what so ever, at first my levels averaged about 150. I had minor out patient surgery in Oct, and since then my levels have bee 200 and higher at one point 383 which in my book is high. I have not experienced any weight loss even though I have tightened my belt by one whole. I am 6ft and 261 lbs male.

I have been working out for a little more than a month with no benefits coming to bear which is aggravating to say the least any help here? Current Meds, B10, actos45mg, met Forman er500mg, altace2.5mg I really want to kick this in the pants and I am feeling beat up with the lack of results. To top it off I am a healthy eater fresh veggies meats cooked correctly (not fried) snacks during the day. Help!

 

Azle


debsonline2
Regular Member


Date Joined Aug 2006
Total Posts : 33
   Posted 11/28/2006 10:42 AM (GMT -7)   
Hi Jennifer. I have been on byetta since July and have had tremendous success! My bgs "almost" look like those of a "normal" person..LOL! There ARE side effects and nausea is the number 1, but after about 3 weeks on the 5 mcg it went away. when I started the 10 mcg, I really didnt notice a difference. I have lost 35 pounds and have so much more energy! My A1C was 5.9 on my last checkup....down from 6.3 earlier in the year. The shots are pretty painless....you can inject in several different places, so find the one that works best for you. I normally inject in the abdomen....it seems I get better absorption when I do. Every now and then I hit a capillary and get a "lovely multicolored bruise" but not very often! I take 500 mg of Metformin ER 2x a day and 4 mg avandia once a day. Definitely give it a shot!

Jeannie143
Veteran Member


Date Joined Apr 2004
Total Posts : 6056
   Posted 11/28/2006 11:35 AM (GMT -7)   
Azle,
Please contact your doctor about switching you to a different med, possibly Lantus insulin. You may be one of the people for whom Byetta does not work... Those numbers are not acceptable. Wish I could be more helpful.

Perhaps another Byetta person will come along with a better idea.
~ Jeannie

"People are like stained glass windows: They sparkle and shine when the sun's out, but when the darkness sets in, their true beauty is revealed only if there is light within."

- Elizabeth Kubler-Ross


Warren
Veteran Member


Date Joined Oct 2005
Total Posts : 534
   Posted 11/28/2006 11:51 AM (GMT -7)   

Hi Azle,

Well, those numbers are telling you the Byetta is not working for you.  You may not be a type 2 any longer or your pancreas function may be broken to the point where the Actos and the Byetta really aren't working for you.  In any event you need to see your doctor ASAP as those numbers are numbers that will lead you to kidney failure and heart disease just to mention a few nasty side effects.

 

scool Warren

jkirkman
Regular Member


Date Joined Nov 2006
Total Posts : 20
   Posted 11/29/2006 10:51 AM (GMT -7)   
Hello everyone!
 
I took my first Byetta injection this morning, and lo and behole felt very sick to my stomach about 1 hour later, throwing up my entire breakfast. Other than that I feel okay, except right now my sugar is 247- confused !!!!!   Go figure!
 
I ate lunch and am holding that down okay but since I have to inject before dinner-don't know what will happen then.
 
This whole thing with my blood sugar is really weird. It's hard to figure out this morning why it went from 213 down to 92 before I threw up, and then after lunch now eaten successfully it goes up to 247.
 
My doctor is keeping me on Metformin, (3 pils a day, along with Actos, 1 pill a day.) He decided I should drop the Glucotrol at this time.
 
Jennifer

Warren
Veteran Member


Date Joined Oct 2005
Total Posts : 534
   Posted 11/29/2006 2:09 PM (GMT -7)   
Hi jennifer,
 
Whats happening to you is the complaint of many a Byetta user; WHAT DO I DO about LUNCH!!!!
 
Byetta has a half life of only about 2.4 hours which means in about 5-6 hours its not really doing much in your system any more.  Given that you could eat breakfast about 8am, that means by noon to 1pm there isn't any Byetta working in your system to amelorate lunch; therefore you are popping back up to 200+. 
 
You can't really take an extra Byetta shot during the day, but you could take a glucatrol that you eliminated, at "lunch".  This will give you a temporary insulin boost to counter the food you eat. Talk that over with your doctor and see if that might not help bring your lunch numbers down.  What we really want to see is to have your meds keep you about 100 ALL the time!!!
 
scool  Warren
 
PS - Hang in there, the nausea really does go away!!  Also there are clinical trials going on with a Byetta that is once a day, so that could eventually deal with the midday meal problem

jkirkman
Regular Member


Date Joined Nov 2006
Total Posts : 20
   Posted 11/30/2006 8:08 AM (GMT -7)   
Thanks Warren! That was a good suggestion and my doc is open-minded to other options all the time. I can see you are of a great source of help to people here-so glad to have you as another advisor!

Jennifer

azle
New Member


Date Joined Nov 2006
Total Posts : 4
   Posted Today 9:36 AM (GMT -7)   

B.I.N.G.O.

Well went to the Dr Thursday and he left my Meds alone and added 4 units Lantis nightly injections (to increase nightly until my levels are 110 range)which by the way have also NOT helped. my fasting levels have been above 220 except for Sunday morning 179 and Saturday night 419. I am going back tomorrow for a another check up, what gives?


jkirkman
Regular Member


Date Joined Nov 2006
Total Posts : 20
   Posted Today 5:03 PM (GMT -7)   
As I continue the Byetta injections without nausea now, (it stopped after 3 days on Byetta),or other unpleasant side effects, my numbers are more normal sometimes now except for yesterday.
I started at 131 in the morning and went all the way to 250 after lunch, and then bottomed out at 56 after taking Glucotrol to get rid of that high number. I remained low until bedtime when I jumped back up to 130. Go figure! This is about the weirdest disease I think I've heard of and watched!

Jennifer

Warren
Veteran Member


Date Joined Oct 2005
Total Posts : 534
   Posted 12/5/2006 3:22 PM (GMT -7)   

Wow Jennifer, that Glucotrol really did the trick!!  I get shakey and have all the hypo symptoms if I sink into the 50's and immediately go to the freezer for my "cure".....a hagendaz ice cream bar!!  Get yourself a pill splitter at the drugstore as its a good way to experiment with "half" doseages.  Now, lets talk about what just happened with the low and subsequent high at night.  I'm going to guess that the Glucotrol caused an insulin flow that pushed your blood sugar down. But lets remember, Insulin stimulates the liver to store glucose in the form of glycogen. A large fraction of glucose absorbed from the small intestine is immediately taken up by hepatocytes, which convert it into the storage polymer glycogen.

Insulin has several effects in liver which stimulate glycogen synthesis, the net effect of which is clear: when the supply of glucose is abundant, insulin "tells" the liver to bank as much of it as possible for use later.  It is that "Later" that occured around bedtime and for many people occurs about 3am in the morning, when the liver release this stored sugar and "bingo" up goes your blood sugar!

So.......lets take that pill splitter and cut your metformin dose in half in the morning and save the other half for after lunch, especially if you take a glucotrol at that point in time.  That way the metformin will sensitize you to the insulin release but also inhibit the glucose manufacturing that happens as your glucotrol pushes the insulin up in your body!! (it goes without saying here, you HAVE TO ASK YOUR DOCTOR about all this before you try it)!!!<---Warrens standard disclaimer and saftey notice!!

Now, for the very same reasons Im recommending you try the aforementioned Im not kean on your moving to Lantus at this time.  You don't want to permantently raise the insulin level in your system over a 24 hour period if you can control the spikes as they occur.  Increasing your basal level of insulin will increase your manufacture of Triglicerides, fat production and again, the manufacture and storage of glucose in your liver.  For those of us that DON't use Byetta, Lantus can be a godsend, but if you have that magic bullet called Byetta and your orals appear to be working, some creative timing as Claire showed us in an earlier post may be the key to keeping your spikes at lower levels !!!

I hope this helped and didn't add to the confusion!

scool  Warren

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