Not sure if this is the right Rx

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tutorgirl
Regular Member


Date Joined Aug 2007
Total Posts : 235
   Posted 9/23/2007 7:54 PM (GMT -6)   
OK, so I went to the pharmacy to pick up what I thought was going to be the metformin extended release and instead it was just plain metformin 1000mg and the doc has me taking 2 tablets at dinner...that's 2000mg at once. Does that seem right? I also start Januvia 100mg tomorrow morning. Now, I specifically spoke with the doc about using the XR. When I originally went to the pharmacy on Tuesday to pick it up, the pharmacist told me what she had prescribed so I asked him to call the doc and check it out. When I went into today he said he never heard back from her. Does anyone know enough about metformin to know if that much at once is safe? I went ahead and got the prescription and took it tonight. I may be stupid assuming she knows what she is doing. Nothing is ever easy, is it.

Karen

gelchick
Regular Member


Date Joined Aug 2006
Total Posts : 477
   Posted 9/24/2007 8:04 AM (GMT -6)   
Hi Karen
 
You can take up to 2500 mg of metformin a day. I would think that you'd want to space them out so you can lessen the gastro effects. I used to take all of mine at night, but now I take 500 with breakfast, 500 with lunch and 1000 at night. I take my Januvia either at dinner or at night (depending on if I am travelling).
 
When I was taking the XR- I took 1000 mg at 9AM and 9PM for constant coverage-
sandy


I just want to live happily ever after-every now and then. Jimmy Buffett


tutorgirl
Regular Member


Date Joined Aug 2007
Total Posts : 235
   Posted 9/24/2007 8:48 AM (GMT -6)   
Sandy, I was thinking the same thing myself. I think I am going to split the dosage and and take one in the morning and one at night. The tablets do have the split mark on the. Do you think I could cut one in half or not? Also, why do you take the Januvia in the morning? I am trying to figure out what is going to work best with that weird mid-morning spike I have. The doc had no suggestions for that one.

Karen

gelchick
Regular Member


Date Joined Aug 2006
Total Posts : 477
   Posted 9/24/2007 10:15 AM (GMT -6)   
Hi Karen,
 
As I understand it, once you take Januvia for awhile, you always have some in circulation (like the TZDs) - so you need to take it every 24 hours. The half-life is about 12 hours, so it peaks around then. I take it in the afternoon/evening to help keep my Dawn Phenomenon under control. That's why I take so much metformin at night too. My numbers are great during the day- 80's most of the time, but rise during the night no matter how low I am before bed, what time I eat dinner, what I eat for dinner, what kind of snack I eat or don't eat, exerceise before dinner, before bed, both - I've tested a lot of variables. My liver is just out to defeat me- so I need to beat it back. I take the second metformin with my largest meal of the day either lunch or dinner- it has a 2-3 hour half life - so hopefully is helping me to use all the glucose from my carbiest meal.
 
Januvia has stabilized my numbers, so that I don't have radical swings (like I did with glipizide), and I don't have to eat carbs to prevent dropping into the low 60's. It's there when I need it. It helped lower my AM numbers so that I am below 100 now 99% of the time (mostly mid to low 90's) as long as I take it between 4 and 8 PM ( I do take it later if I'm traveling and it's more convenient to do so)- no food needed with it, unlike metformin.
 
When my doctor prescribed it, she told me to take it when I would remember best- but close to the same time every day. When I travel, I try to take it once avery 24 hours no matter what the clock says (I travel from Eastern to Pacific time for work a lot, and to London 2-3 times a year.
sandy
I just want to live happily ever after-every now and then. Jimmy Buffett

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