I've not heard of nausea very often as a side effect from our patients due to Depakote; I'm sure it's different for each person. Also, as far as the liver failure is concerned, as long as your neurologist keeps tabs on your liver function (labs) every few months, it shouldnt be come an issue. We check CBC, liver function, and med levels at least every 3 months to make sure everything is kosher. If anything changes as far as the liver function is concerned, we discuss with the patient the options of switching medications. Just remember, there are side effects with ALL medications, and the percentages of most of those are low. All you can do is try the medication and work in partnership with your doctor about any issues you may be having.