Long term effects of depakote

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groovyartgirl
New Member


Date Joined Sep 2009
Total Posts : 3
   Posted 9/10/2009 6:35 PM (GMT -6)   
I was misdiagnosed and was on depakote for 12 years for bipolar treatment. I have now been off of depakote for over 6 years. The last 2 years I have been diagnosed with collagenous colitis which is an inflammation of the intestines. Has anyone else experiences any long term gastrointestinal effects from the use of depakote? or has anyone developed gastrointestinal problems after discontinuing depakote?

Thanks

Ruth

Stella Marie
Veteran Member


Date Joined May 2005
Total Posts : 601
   Posted 9/24/2009 12:18 AM (GMT -6)   
Interesting, I took Depakote for about 4 years and ended up with...Collogenous Colitis too! I was took that it was an organic problem unrelated to the Depakote.

Depakote does cause weight gain and has a major warning for polycyctic ovary disease in younger females.

I actually do not this the colitis and depakote are related, but knows!

Stella Marie

Co-Forum Moderator for Chronic Pain

Rare neurodegenerative /movement disorder called “Multiple System Atrophy”.  Mobility issues,, neuropathic pain,  spasticity, central apnea, collagenous colitis, joint and body pain, swallowing and respitory  involvement,  Implants: intrathecal pump  & neurostimulator.  Extra features: O2 & wheelchair

 


RanMan
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Date Joined Feb 2003
Total Posts : 653
   Posted 9/25/2009 11:17 AM (GMT -6)   
nono nono This is a post I made on another web site. I thought it might be of some interest b/c there is some epilepsy mention in it. I've had Ulcerative Colitis and Epilepsy since 1979 ~ both of these conditions are believed to be stress related but that fact has yet to be proven. As you know, stress effects everybody differently and this is what it has done to me. It has been documented that ppl with EP have a greater chance of getting some sort of bowel condition (IBS)or visa/versa as there are so many nerves in the digestive tract that "could" be affected by a seizure condition.
Some of the first symptoms to watch for are: 1) first sign is mucus in the stools ~ then blood in the stools.
2) Feeling that you always have to empty your bowels ~ sometimes every 15 mins or every hour (depending on the severity)
3) When you go to the washroom, all you get is Lots of gas accompanied with blood and/or mucus.
4) bloating of the stomach.
5) Usually flares up AFTER a stressful event (same as a seizure or anaura) or if you've been eating acidy foods or caffine or dairy prods.

But I find it's very well controlled with medication.
I usually have a flare up every 2 yrs.
Very tricky to control though with my Epilepsy, like walking a tight rope.
My blood levels have to be monitored weekly so I can maintain the theraputic level for my AED's but not mess up my UC med count. IE: My UC meds paint a protective coating on the bowel and stomach walls and as a result, the AED's can't motabilize properly ~ then if you increase yor AED's, they could become toxic in your system or if you have a flare up, you have to increase your doseage of the UC meds (mine is Asasol) then it's that much harder for the AED's to penetrate the stomach and bowel so if you increase your doseage of AED's, they can become toxic and you will act like a drunk or stoner.

What I have found is that a flare up or EP seizure will happen AFTER a stressful event like I said above b/c during a relaxed time, your body's natural defenses are down.

Since I have EP and UC, my neurologist says it's very difficult to control.
I'm currently seeing Dr. A. Upton, proffessor of Neurology, McMaster Univerity Medical Centre, He's lectured on my case and it has been documented in the 1986 Medical Journal.

Randy
diagnosed with epilepsy and Ulcerative Colitis in 1979

Diagnosed with Epilepsy & Ulcerative Colitis.
Current Medications: Diantin 275mg, Pheonobarb 150mg, Asocol 3,000 mg.


BigM
New Member


Date Joined Jan 2010
Total Posts : 1
   Posted 1/28/2010 4:41 PM (GMT -6)   
        Hello ,
       I am on Depekene 250 mg. 1500 mg. per day.  Twice three time per day morning/noon/night/.  I tried Doepakone when I was in my 20s. .  It put me to sleep and Did I ever sleep.  I was off from my job for 1 week.  I had no apatite and slept all day.  Do it was stopped after one dosage. 
       Ten years ago. I went from one pharmacy to another.  I was given the cheap brand, (generic) of Depekene, know as Valproic acid.  I only took two of them which I was told by all my Mds., Nuro. doc. never to take.  Its side affect made me vomit, the runs and now it rotted my intestinss.  I had emergency surgery in 05.  So I lost that and my colon as well. 
      So always read up on any med even the ones you are recomened to take by your doc. . REsearchc it well.  My outcomes was not good.  I had three hert attackss in surgery too.   Sp I am back to the DEpakene which works beest for me.
         confused
      

dll123
New Member


Date Joined Feb 2010
Total Posts : 1
   Posted 2/13/2010 1:07 AM (GMT -6)   
Took Depakote for about 2 months when I began having constipation to an extreme degree. Went off it, constipation went away. Back on the next week and it came back. Saw another psych doc and he said I was misdiagnosed. Put me on depression meds vs. bipolar and my mental state improved dramatically. Unfortunately I began having diarrhea dominant IBS. Have had it for 5 years now. Never had bowel issues before Depakote and have had 3 colonoscopies since trying to determine why I have lots of dark and bright blood in stool with mucus and now have iron deficient anemia (hemoglobin count went from 17 to 9 in 3 months). Passed out once a few months ago and have not been able to climb more than one flight of stairs without becoming winded due to oxygen levels (associated with iron deficiency).

I can't say 100% that Depakote caused these issues, but the facts seem to point that way. Knowing it wreaks havoc on your liver makes me even more suspicious. May be fine for some but I fear some of us will never be the same after taking it for even a short while, much less several years!

mshonda
New Member


Date Joined Mar 2010
Total Posts : 4
   Posted 3/18/2010 9:20 AM (GMT -6)   
RanMan said...
This is a post I made on another web site. I thought it might be of some interest b/c there is some epilepsy mention in it. I've had Ulcerative Colitis and Epilepsy since 1979 ~ both of these conditions are believed to be stress related but that fact has yet to be proven. As you know, stress effects everybody differently and this is what it has done to me. It has been documented that ppl with EP have a greater chance of getting some sort of bowel condition (IBS)or visa/versa as there are so many nerves in the digestive tract that "could" be affected by a seizure condition.
Some of the first symptoms to watch for are: 1) first sign is mucus in the stools ~ then blood in the stools.
2) Feeling that you always have to empty your bowels ~ sometimes every 15 mins or every hour (depending on the severity)
3) When you go to the washroom, all you get is Lots of gas accompanied with blood and/or mucus.
4) bloating of the stomach.
5) Usually flares up AFTER a stressful event (same as a seizure or anaura) or if you've been eating acidy foods or caffine or dairy prods.


Randy that's a very useful piece of info, never heard of that one. I have got some blood in the stool and am due to have it checked.

Thanks again.

kind regards,

depakotesurvivor
New Member


Date Joined Aug 2010
Total Posts : 1
   Posted 8/28/2010 12:50 PM (GMT -6)   
I took Depakote for Bipolar Disorder with rapid cycling Mania; for six months. I was misdiagnosed and have been diagnose for three years with GAD; OCD; and ADD. I am doing better after my memories returned three weeks ago. Even though I begged to be put on a different med like Lithium; and kept saying "something wasn't right", it took me at least ten episodes of psychosis until I got another doctor and now am looking into malpractice. My short term side effects included: psychosis, hallucinations, photsensitivity, abnormal dreams, induced mania,

long term to permanent: developed Avoidant Disorder and Dependent Personality Disorder; frequent UTI infections, perm. damage to CNS including extreme muscle spasms in back and tremors, problems with short term memory and just recovered memories of that year from amnesia. I will never remember the psychosis. I lost my first husband and my current one is almost final. I had behavioral detereioration up until this year when I started to find out who I really am. I can no longer deal with change at all as I used to have problems with it but wasn't debilitating; mistake or instability. Ataxia, parasthesia, lability, tremors, CNS damage, Aggression, Mental Hyperactivity; hositility and behavioral deterioration.

danielleneckpain
New Member


Date Joined Nov 2010
Total Posts : 2
   Posted 11/13/2010 4:29 PM (GMT -6)   
What is the other name of Depakote : is it Tegretol or Topamax ?

My 10 year old son is epileptic and took those two drugs until this spring. I'm trying to relate what is said here about depakote. THanks

tent63
New Member


Date Joined Nov 2010
Total Posts : 9
   Posted 11/17/2010 2:05 AM (GMT -6)   
My son took Depakote for 5 years to control seizures...immediately had heavy weight gain.  6 years down the road and he is still fighting the weight issue. We also noticed that he was "dull" when he was on it.  We took him off as soon as we could.  It did control his seizures and I am thankful for that small miracle but the lasting effects are rough.

DorEli53
New Member


Date Joined Nov 2010
Total Posts : 1
   Posted 11/20/2010 11:42 PM (GMT -6)   
danielleneckpain said...
What is the other name of Depakote : is it Tegretol or Topamax ?

My son took Depakene for years for epilepsy. He took the liquid form called valproic acid. He has had problems with his teeth, decalcification ever since he started taking it and at the age of 18 he learned he had degenerative disc disease. Surgery did not resolve this issue and now it is more severe.
I have believed for years that the depakene was the culprit but the Dr's won't admit it
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